The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Ninety-Minute Exclusion of Acute Myocardial Infarction By Use of Quantitative Point-of-Care Testing of Myoglobin and Troponin I
Abstract
Background Diagnostic strategies with ECG and serum cardiac markers have been used to rule out acute myocardial infarction in 6 to 12 hours. The present study evaluated whether a multimarker strategy that used point-of-care measurement of myoglobin, creatine kinase (CK)-MB, and troponin I could exclude acute myocardial infarction in ≤3 hours. Methods and Results We prospectively enrolled consecutive patients (n=817) in the emergency department who were evaluated for possible acute myocardial infarction. In patients with nondiagnostic ECGs, we measured CK-MB, troponin I, and myoglobin with a point-of-care device at presentation and at 90 minutes, 3 hours, and 9 hours. Standard central laboratory testing of CK-MB was done at the same time intervals, and triage decisions were made by emergency physicians who were unaware of point-of-care results. Sensitivity and negative predictive value were compared for both the multimarker, point-of-care approach and the central laboratory strategy. Sensitivity and negative predictive value for point-of-care combination of myoglobin and troponin I by 90 minutes was 96.9% and 99.6%, respectively. CK-MB measurements and blood sampling at 3 hours did not improve sensitivity or negative predictive value. Median time from sampling to reporting of results was 71.0 minutes for the central laboratory versus 24.0 minutes for the point-of-care device ( P <0.001). Conclusions Acute myocardial infarction can be excluded rapidly in the emergency department by use of point-of-care measurements of myoglobin and troponin I during the first 90 minutes after presentation.
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Cites
Antman, E., Bassand, J.-P., Klein, W., Ohman, M., Lopez Sendon, J. L., Rydén, L., Simoons, M., & Tendera, M. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00804-4 · Cited by 4,821
Braunwald, E., Antman, E. M., Beasley, J. W., Califf, R. M., Cheitlin, M. D., Hochman, J. S., Jones, R. H., Kereiakes, D., Kupersmith, J., Levin, T. N., et al. (2000) · Circulation · doi:10.1161/01.cir.102.10.1193 · Cited by 4,487
Missed Diagnoses of Acute Cardiac Ischemia in the Emergency Department
Pope, J. H., Aufderheide, T. P., Ruthazer, R., Woolard, R. H., Feldman, J. A., Beshansky, J. R., Griffith, J. L., & Selker, H. P. (2000) · New England Journal of Medicine · doi:10.1056/nejm200004203421603 · Cited by 1,794
Antman, E. M., Tanasijevic, M. J., Thompson, B., Schactman, M., McCabe, C. H., Cannon, C. P., Fischer, G. A., Fung, A. Y., Thompson, C., Wybenga, D., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199610313351802 · Cited by 1,749
Lindahl, B., Toss, H., Siegbahn, A., Venge, P., & Wallentin, L. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010193431602 · Cited by 1,224
Hamm, C. W., Goldmann, B. U., Heeschen, C., Kreymann, G., Berger, J., & Meinertz, T. (1997) · New England Journal of Medicine · doi:10.1056/nejm199712043372302 · Cited by 1,039
A Rapid Diagnostic and Treatment Center for Patients With Chest Pain in the Emergency Department
GIBLER, W., RUNYON, J., LEVY, R., SAYRE, M., KACICH, R., HATTEMER, C., HAMILTON, C., GERLACH, J., & WALSH, R. (1995) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(95)70347-0 · Cited by 405
Wu, A. H. B., Feng, Y.-J., Moore, R., Apple, F. S., McPherson, P. H., Buechler, K. F., Bodor, G., for, F. T. A. A., & Standardization, C. C. S. O. C. (1998) · Clinical Chemistry · doi:10.1093/clinchem/44.6.1198 · Cited by 393
de Winter, R. J., Koster, R. W., Sturk, A., & Sanders, G. T. (1995) · Circulation · doi:10.1161/01.cir.92.12.3401 · Cited by 317
Labugger, R., Organ, L., Collier, C., Atar, D., & Van Eyk, J. E. (2000) · Circulation · doi:10.1161/01.cir.102.11.1221 · Cited by 315
Cited by
Anderson, J. L., Adams, C. D., Antman, E. M., Bridges, C. R., Califf, R. M., Casey, D. E., Chavey, W. E., Fesmire, F. M., Hochman, J. S., Levin, T. N., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.02.013 · Cited by 1,510
Anderson, J. L., Adams, C. D., Antman, E. M., Bridges, C. R., Califf, R. M., Casey, D. E., Chavey, W. E., Fesmire, F. M., Hochman, J. S., Levin, T. N., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.01.014 · Cited by 960
Point-of-Care Diagnostics in Low Resource Settings: Present Status and Future Role of Microfluidics
Sharma, S., Zapatero-Rodríguez, J., Estrela, P., & O'Kennedy, R. (2015) · Biosensors · doi:10.3390/bios5030577 · Cited by 349
Point-of-care immunotesting: Approaching the analytical performance of central laboratory methods
von Lode, P. (2005) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2005.03.008 · Cited by 290
2007 WRITING COMMITTEE MEMBERS, Anderson, J. L., Adams, C. D., Antman, E. M., Bridges, C. R., Califf, R. M., Casey, D. E., Chavey, W. E., Fesmire, F. M., Hochman, J. S., et al. (2013) · Circulation · doi:10.1161/cir.0b013e31828478ac · Cited by 272
Metadata
- Authors
- McCord, J., Nowak, R. M., McCullough, P. A., Foreback, C., Borzak, S., Tokarski, G., Tomlanovich, M. C., Jacobsen, G., & Weaver, W. D.
- Venue
- Circulation
- Published
- 2001-09-25
- Volume
- 104
- Issue
- 13
- Pages
- 1483-1488
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2008644554
- Cited by
- 297
- References
- 16
- FWCI
- 11.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- McCord, J., Nowak, R. M., McCullough, P. A., Foreback, C., Borzak, S., Tokarski, G., Tomlanovich, M. C., Jacobsen, G., & Weaver, W. D. (2001). Ninety-Minute Exclusion of Acute Myocardial Infarction By Use of Quantitative Point-of-Care Testing of Myoglobin and Troponin I. Circulation. https://doi.org/10.1161/hc3801.096336
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