In Vivo Myocardial Protection From Ischemia/Reperfusion Injury by the Peroxisome Proliferator–Activated Receptor-γ Agonist Rosiglitazone
Abstract
BackgroundDiabetes is associated with increased risk of mortality as a consequence of acute myocardial infarction. This study determined whether rosiglitazone (ROSI) could reduce myocardial infarction after ischemia/reperfusion injury. Methods and ResultsMale Lewis rats were anesthetized, and the left anterior descending coronary artery was ligated for 30 minutes. After reperfusion for 24 hours, the ischemic and infarct sizes were determined. ROSI at 1 and 3 mg/kg IV reduced infarct size by 30% and 37%, respectively (P<0.01 versus vehicle). Pretreatment with ROSI (3 mg · kg−1· d−1 PO) for 7 days also reduced infarct size by 24% (P<0.01). ROSI also improved ischemia/reperfusion-induced myocardial contractile dysfunction. Left ventricular systolic pressure and positive and negative maximal values of the first derivative of left ventricular pressure (dP/dt) were significantly improved in ROSI-treated rats. ROSI reduced the accumulation of neutrophils and macrophages in the ischemic heart by 40% and 43%, respectively (P<0.01). Ischemia/reperfusion induced upregulation of CD11b/CD18 and downregulation of L-selectin on neutrophils and monocytes; these effects were significantly attenuated in ROSI-treated animals. Likewise, intercellular adhesion molecule-1 expression in ischemic hearts was markedly diminished by ROSI, as was the ischemia/reperfusion-stimulated upregulation of monocyte chemoattractant protein-1. ConclusionsROSI reduced myocardial infarction and improved contractile dysfunction caused by ischemia/reperfusion injury. The cardioprotective effect of ROSI was most likely due to inhibition of the inflammatory response.
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Studies in nondiabetic rats have shown a positive benefit of TZD treatment upon ischemia/reperfusion, although this has not been shown to be true for other models such as pigs.
“Studies in nondiabetic rats have also shown a positive benefit of TZD treatment upon ischemia/reperfusion (158, 176, 390), although this has not been shown to be true for other models such as pigs (380).”
From Cardiac remodeling in obesity (2008) · cites this paper as [390]
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Cites
Chawla, A., Barak, Y., Nagy, L., Liao, D., Tontonoz, P., & Evans, R. M. (2001) · Nature Medicine · doi:10.1038/83336 · Cited by 1,069 · see citing works
Myocardial Cell Death in Human Diabetes
Frustaci, A., Kajstura, J., Chimenti, C., Jakoniuk, I., Leri, A., Maseri, A., Nadal-Ginard, B., & Anversa, P. (2000) · Circulation Research · doi:10.1161/01.res.87.12.1123 · Cited by 796 · see citing works
A novel therapy for colitis utilizing PPAR-γ ligands to inhibit the epithelial inflammatory response
Su, C. G., Wen, X., Bailey, S. T., Jiang, W. G., Rangwala, S. M., Keilbaugh, S. A., Flanigan, A., Murthy, S., Lazar, M. A., & Wu, G. D. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7145 · Cited by 769 · see citing works
Self-citationThe role of neutrophils in myocardial ischemia–reperfusion injury
Jordan, J. E. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00187-x · Cited by 647 · see citing works
The role of PPAR-γ in macrophage differentiation and cholesterol uptake
Moore, K. J., Rosen, E. D., Fitzgerald, M. L., Randow, F., Andersson, L. P., Altshuler, D., Milstone, D. S., Mortensen, R. M., Spiegelman, B. M., & Freeman, M. W. (2001) · Nature Medicine · doi:10.1038/83328 · Cited by 513 · see citing works
Buerke, M., Murohara, T., Skurk, C., Nuss, C., Tomaselli, K. J., & Lefer, A. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.8031 · Cited by 394 · see citing works
Ricote, M., Huang, J. T., Welch, J., & Glass, C. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.5.733 · Cited by 392 · see citing works
Peroxisome proliferator‐activated receptors in the cardiovascular system
Bishop‐Bailey, D. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703149 · Cited by 358 · see citing works
Mechanisms of myocardial reperfusion injury
Park, J. L., & Lucchesi, B. R. (1999) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(99)01073-5 · Cited by 338 · see citing works
Aronson, D., Rayfield, E. J., & Chesebro, J. H. (1997) · Annals of Internal Medicine · doi:10.7326/0003-4819-126-4-199702150-00006 · Cited by 305 · see citing works
Furie, M. B., & Randolph, G. J. (1995) · Europe PMC (PubMed Central) · Cited by 297 · see citing works
Lee, H., Shi, W., Tontonoz, P., Wang, S., Subbanagounder, G., Hedrick, C. C., Hama, S. Y., Borromeo, C. M., Evans, R. M., Berliner, J. A., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.6.516 · Cited by 291 · see citing works
Woodfield, S. L., Lundergan, C. F., Reiner, J. S., Greenhouse, S. W., Thompson, M. A., Rohrbeck, S. C., Deychak, Y. A., Simoons, M. L., Califf, R. M., Topol, E. J., et al. (1996) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(96)00397-x · Cited by 280 · see citing works
Neutrophil rolling altered by inhibition of L-selectin shedding in vitro
Walcheck, B. K., Kahn, J., Fisher, J. M., Wang, B., Fisk, R. S., Payan, D. G., Feehan, C., Betageri, R., Darłak, K., Spatola, A. F., et al. (1996) · Nature · doi:10.1038/380720a0 · Cited by 272 · see citing works
Young, P. W., Buckle, D. R., Cantello, B. C. C., Chapman, H., Clapham, J. C., Coyle, P. J., Haigh, D., Hindley, R. M., Holder, J. C., Kallender, H., et al. (1998) · PubMed · Cited by 229 · see citing works
Endogenous PPARγ mediates anti-inflammatory activity in murine ischemia-reperfusion injury
Nakajima, A., Wada, K., Miki, H., Kubota, N., Nakajima, N., Terauchi, Y., Ohnishi, S., Saubermann, L. J., Kadowaki, T., Blumberg, R. S., et al. (2001) · Gastroenterology · doi:10.1053/gast.2001.21191 · Cited by 215 · see citing works
Balfour, J. A. B., & Plosker, G. L. (1999) · Drugs · doi:10.2165/00003495-199957060-00007 · Cited by 198 · see citing works
Takano, H., Nagai, T., Asakawa, M., Toyozaki, T., Oka, T., Komuro, I., Saito, T., & Masuda, Y. (2000) · Circulation Research · doi:10.1161/01.res.87.7.596 · Cited by 181 · see citing works
Meisel, S. R., Shapiro, H., Radnay, J., Neuman, Y., Khaskia, A.-R., Gruener, N., Pauzner, H., & David, D. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00424-5 · Cited by 154 · see citing works
Savage, M. P., Królewski, A. S., Kenien, G., Lebeis, M. P., Christlieb, A. R., & Lewis, S. M. (1988) · The American Journal of Cardiology · doi:10.1016/0002-9149(88)91199-x · Cited by 144 · see citing works
Myocardial ischemia-reperfusion injury in CD18- and ICAM-1-deficient mice
Palazzo, A. J., Jones, S. P., Girod, W. G., Anderson, D. C., Granger, D. N., & Lefer, D. J. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.275.6.h2300 · Cited by 116 · see citing works
Behr, T. M., Wang, X., Aiyar, N. V., Coatney, R. W., Li, X., Koster, P. D., Angermann, C. E., Ohlstein, E. H., Feuerstein, G., & Winaver, J. M. (2000) · Circulation · doi:10.1161/01.cir.102.11.1315 · Cited by 115 · see citing works
Self-citationYoung, P. W., Buckle, D. R., Cantello, B. C. C., Chapman, H., Clapham, J. C., Coyle, P. J., Haigh, D., Hindley, R. M., Holder, J. C., Kallender, H., et al. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37268-4 · Cited by 101 · see citing works
Ono, K., Matsumori, A., Furukawa, Y., Igata, H., Shioi, T., Matsushima, K., & Sasayama, S. (1999) · PubMed · Cited by 92 · see citing works
Troglitazone Improves Recovery of Left Ventricular Function After Regional Ischemia in Pigs
Zhu, P., Li, L., Xu, Y., & Schwartz, G. G. (2000) · Circulation · doi:10.1161/01.cir.101.10.1165 · Cited by 90 · see citing works
Ma, X. L., Yue, T. L., Lopez, B. L., Barone, F. C., Christopher, T. A., Ruffolo, R. R., Jr., & FEUERSTEIN, G. Z. (1996) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12798-5 · Cited by 80 · see citing works
Self-citationNarayanan, P. K., Carter, W. O., Ganey, P. E., Roth, R. A., Voytik‐Harbin, S. L., & Robinson, J. P. (1998) · Journal of Leukocyte Biology · doi:10.1002/jlb.63.2.216 · Cited by 49 · see citing works
Self-citationGibson, C. M., Kuntz, R. E., Nobuyoshi, M., ROSNER, B. A., & Baim, D. S. (1993) · Circulation · doi:10.1161/01.cir.87.4.1123 · Cited by 48 · see citing works
Cardioprotective effects of troglitazone in streptozotocin-induced diabetic rats
Shimabukuro, M., Higa, S., Shinzato, T., Nagamine, F., Komiya, I., & Takasu, N. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90018-9 · Cited by 43 · see citing works
Myocardial infarction in the diabetic patient
Kereiakes, D. J. (1985) · Clinical Cardiology · doi:10.1002/clc.4960080808 · Cited by 39 · see citing works
Roth, A., Keren, G., Shapira, I., Arber, N., Kassirer, M., Zeltser, D., Rotstein, R., Gluzman, B., Leibovitz, E., & Goldberg, Y. (1999) · Clinical Cardiology · doi:10.1002/clc.4960221109 · Cited by 17 · see citing works
Shock induced hyperpolarization activates sodium channels
Ujhelyi, M. R., Zhou, X., & Creazzo, T. L. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)81167-4 · Cited by 10 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Myocardial Fatty Acid Metabolism in Health and Disease
Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00015.2009 · Cited by 2,180 · see citing works
Inflammatory Cytokines and Postmyocardial Infarction Remodeling
Nian, M., Lee, P. C., Khaper, N., & Liu, P. J. (2004) · Circulation Research · doi:10.1161/01.res.0000130526.20854.fa · Cited by 1,031 · see citing works
PPAR control of metabolism and cardiovascular functions
Montaigne, D., Butruille, L., & Staels, B. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00569-6 · Cited by 960 · see citing works
Haffner, S. M., Greenberg, A. S., Weston, W. M., Chen, H., Williams, K., & Freed, M. I. (2002) · Circulation · doi:10.1161/01.cir.0000025403.20953.23 · Cited by 882 · see citing works
Thiazolidinedione Use, Fluid Retention, and Congestive Heart Failure
Nesto, R. W., Bell, D. S. H., Bonow, R. O., Fonseca, V. A., Grundy, S. M., Horton, E. S., Winter, M. L., Porte, D., Semenkovich, C. F., Smith, S. E., et al. (2003) · Circulation · doi:10.1161/01.cir.0000103683.99399.7e · Cited by 831 · see citing works
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736 · see citing works
Thiazolidinedione Use, Fluid Retention, and Congestive Heart Failure
Nesto, R. W., Bell, D. S. H., Bonow, R. O., Fonseca, V. A., Grundy, S. M., Horton, E. S., Winter, M. L., Porte, D., Semenkovich, C. F., Smith, S. E., et al. (2004) · Diabetes Care · doi:10.2337/diacare.27.1.256 · Cited by 585 · see citing works
Huynh, K., Bernardo, B. C., McMullen, J. R., & Ritchie, R. H. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.01.003 · Cited by 552 · see citing works
Marx, N., Duez, H., Fruchart, J.-C., & Staels, B. (2004) · Circulation Research · doi:10.1161/01.res.0000127122.22685.0a · Cited by 501 · see citing works
Stress-hyperglycemia, insulin and immunomodulation in sepsis
Marik, P. E., & Raghavan, M. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2167-y · Cited by 416 · see citing works
Peroxisome proliferator-activated receptors and inflammation
Moraes, L. A., Piqueras, L., & Bishop‐Bailey, D. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.08.007 · Cited by 377 · see citing works
Peroxisome Proliferator-Activated Receptors
Schiffrin, E. L., Amiri, F., Benkirane, K., Iglarz, M., & Diep, Q. N. (2003) · Hypertension · doi:10.1161/01.hyp.0000084370.74777.b6 · Cited by 369 · see citing works
Wayman, N. S., Hattori, Y., McDonald, M. C., Mota‐Filipe, H., Cuzzocrea, S., PISANO, B., Chatterjee, P. K., & Thiemermann, C. (2002) · The FASEB Journal · doi:10.1096/fj.01-0793com · Cited by 361 · see citing works
Oxidative stress and neutrophil activation--the two keystones of ischemia/reperfusion injury.
Kamiński, K., Bonda, T., Korecki, J., & Musiał, W. (2002) · International Journal of Cardiology · doi:10.1016/s0167-5273(02)00189-4 · Cited by 353 · see citing works
Safety issues and prospects for future generations of PPAR modulators
RUBENSTRUNK, A., HANF, R., HUM, D., FRUCHART, J., & STAELS, B. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2007.02.003 · Cited by 309 · see citing works
Collino, M., Aragno, M., Mastrocola, R., Gallicchio, M., Rosa, A. C., Dianzani, C., Danni, O., Thiemermann, C., & Fantozzi, R. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.11.049 · Cited by 302 · see citing works
Healing after myocardial infarction.
Ertl, G., & Frantz, S. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.01.011 · Cited by 331 · see citing works
Aasum, E., Hafstad, A. D., Severson, D. L., & Larsen, T. S. (2003) · Diabetes · doi:10.2337/diabetes.52.2.434 · Cited by 280 · see citing works
Thiazolidinediones in Type 2 Diabetes Mellitus
Diamant, M., & Heine, R. J. (2003) · Drugs · doi:10.2165/00003495-200363130-00004 · Cited by 278 · see citing works
Sundararajan, S., Gamboa, J. L., Victor, N., Wanderi, E. W., Lust, W. D., & Landreth, G. E. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.10.021 · Cited by 266 · see citing works
Shiomi, T., Tsutsui, H., Hayashidani, S., Suematsu, N., Ikeuchi, M., Wen, J., Ishibashi, M., Kubota, T., Egashira, K., & Takeshita, A. (2002) · Circulation · doi:10.1161/01.cir.0000039346.31538.2c · Cited by 255 · see citing works
The PPAR trio: Regulators of myocardial energy metabolism in health and disease
Madrazo, J., & Kelly, D. P. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.03.021 · Cited by 242 · see citing works
Involvement of PPAR nuclear receptors in tissue injury and wound repair
Michalik, L. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27958 · Cited by 236 · see citing works
Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair
Cai, W., Yang, T., Liu, H., Han, L., Zhang, K., Hu, X., Zhang, X., Yin, K., Gao, Y., Bennett, M. V. L., et al. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.002 · Cited by 238 · see citing works
Self-citationInoue, H., Jiang, X., Katayama, T., Osada, S., Umesono, K., & Namura, S. (2003) · Neuroscience Letters · doi:10.1016/j.neulet.2003.09.001 · Cited by 232 · see citing works
Inhibition of Rho-kinase protects the heart against ischemia/reperfusion injury
Bao, W. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.12.004 · Cited by 224 · see citing works
Self-citationThe PPAR regulatory system in cardiac physiology and disease
Finck, B. N. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.08.023 · Cited by 222 · see citing works
Beneficial effects of PPAR-? ligands in ischemia?reperfusion injury, inflammation and shock
Abdelrahman, M. S. I., Sivarajah, A., & Thiemermann, C. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.12.008 · Cited by 205 · see citing works
Luo, Y., Yin, W., Signore, A. P., Zhang, F., Hong, Z., Wang, S., Graham, S. H., & Chen, J. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03758.x · Cited by 203 · see citing works
Self-citationYue, T., Bao, W., Jucker, B. M., Gu, J.-L., Romanic, A. M., Brown, P. J., Cui, J., Thudium, D. T., Boyce, R. W., Burns-Kurtis, C. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000093187.42015.6c · Cited by 189 · see citing works
Self-citationKhandoudi, N., Delerive, P., Berrebi-Bertrand, I., Buckingham, R. E., Staels, B., & Bril, A. (2002) · Diabetes · doi:10.2337/diabetes.51.5.1507 · Cited by 174 · see citing works
Self-citationWagstaff, A. J., & Goa, K. L. (2002) · Drugs · doi:10.2165/00003495-200262120-00007 · Cited by 175 · see citing works
Insulin says NO to cardiovascular disease
Yu, Q., Gao, F., & Ma, X. L. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq349 · Cited by 172 · see citing works
Yue, T.-L., Bao, W., Gu, J.-L., Cui, J., Tao, L., Ma, X.-L., Ohlstein, E. H., & Jucker, B. M. (2005) · Diabetes · doi:10.2337/diabetes.54.2.554 · Cited by 170 · see citing works
Self-citationMinireview: Challenges and Opportunities in Development of PPAR Agonists
Wright, M. B., Bortolini, M., Tadayyon, M., & Bopst, M. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1427 · Cited by 169 · see citing works
Sidell, R. J., Cole, M. A., Draper, N. J., Desrois, M., Buckingham, R. E., & Clarke, K. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1110 · Cited by 165 · see citing works
Self-citationBacteria‐Derived Outer‐Membrane Vesicles Hitchhike Neutrophils to Enhance Ischemic Stroke Therapy
Pan, J., Wang, Z., Huang, X., Xue, J., Zhang, S., Guo, X., & Zhou, S. (2023) · Advanced Materials · doi:10.1002/adma.202301779 · Cited by 165 · see citing works
Ye, Y., Keyes, K. T., Zhang, C., Perez-Polo, J. R., Lin, Y., & Birnbaum, Y. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00867.2009 · Cited by 152 · see citing works
Tang, W. H. W., Francis, G. S., Hoogwerf, B. J., & Young, J. B. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00159-1 · Cited by 150 · see citing works
Angiotensin II Regulation of Collagen Type I Expression in Cardiac Fibroblasts
Chen, K., Chen, J., Li, D., Zhang, X., & Mehta, J. L. (2004) · Hypertension · doi:10.1161/01.hyp.0000144400.49062.6b · Cited by 148 · see citing works
Self-citationSivarajah, A., Chatterjee, P. K., Patel, N. S. A., Todorović, Z., Hattori, Y., Brown, P. A., Stewart, K. N., Mota‐Filipe, H., Cuzzocrea, S., & Thiemermann, C. (2003) · American Journal of Nephrology · doi:10.1159/000072088 · Cited by 144 · see citing works
Altered PPARγ expression and activation after transient focal ischemia in rats
Victor, N., Wanderi, E. W., Gamboa, J. L., Zhao, X., Aronowski, J. A., Deininger, K. M., Lust, W. D., Landreth, G. E., & Sundararajan, S. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05037.x · Cited by 142 · see citing works
Tao, L., Bei, Y., Lin, S., Zhang, H., Zhou, Y., Jiang, J., Chen, P., Shen, S., Xiao, J., & Li, X. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430342 · Cited by 135 · see citing works
Peroxisome-proliferator-activated receptors regulate redox signaling in the cardiovascular system
Kim, T. (2013) · World Journal of Cardiology · doi:10.4330/wjc.v5.i6.164 · Cited by 131 · see citing works
Robinson, E., & Grieve, D. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.03.003 · Cited by 130 · see citing works
15d-Prostaglandin J 2 Protects Brain From Ischemia-Reperfusion Injury
Lin, T., Cheung, W.-M., Wu, J., Chen, J.-J., Lin, H., Chen, J.-J., Liou, J., Shyue, S., & Wu, K. K. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000201933.53964.5b · Cited by 129 · see citing works
Self-citationBishop‐Bailey, D., & Wray, J. A. (2003) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(03)00003-0 · Cited by 128 · see citing works
Liu, H.-R., Tao, L., Gao, E., Lopez, B., Christopher, T., Willette, R., Ohlstein, E., Yue, T., & Ma, X.-L. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.12.027 · Cited by 131 · see citing works
Cheng, L., Ding, G., Qin, Q., Xiao, Y., Woods, D., Chen, Y. E., & Yang, Q. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.11.127 · Cited by 121 · see citing works
Mehta, J. L., Hu, B., Chen, J., & Li, D. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000094411.98127.5f · Cited by 121 · see citing works
Self-citationAngiotensin II Type 1 Receptor–Mediated Inflammation Is Required for Choroidal Neovascularization
Nagai, N., Oike, Y., Izumi‐Nagai, K., Urano, T., Kubota, Y., Noda, K., Ozawa, Y., Inoue, M., Tsubota, K., Suda, T., et al. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000240050.15321.fe · Cited by 120 · see citing works
Guo, L., & Tabrizchi, R. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.10.009 · Cited by 117 · see citing works
Akaike, M., Che, W., Marmarosh, N.-L., Ohta, S., Osawa, M., Ding, B., Berk, B. C., Chen, Y., & Abe, J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.19.8691-8704.2004 · Cited by 115 · see citing works
Adiponectin Is Required for PPARγ-Mediated Improvement of Endothelial Function in Diabetic Mice
Wong, W. T., Tian, X. Y., Xu, A., Yu, J. Q., Lau, C. W., Hoo, R. L. C., Wang, Y., Lee, V. W. Y., Lam, K. S. L., Vanhoutte, P. M., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.009 · Cited by 115 · see citing works
Wu, J., Cheung, W.-M., Tsai, Y.-S., Chen, Y.-T., Fong, W.-H., Tsai, H.-D., Chen, Y., Liou, J., Shyue, S., Chen, J.-J., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.812537 · Cited by 114 · see citing works
Self-citationOkamoto, H., Iwamoto, T., Kotake, S., Momohara, S., Yamanaka, H., & Kamatani, N. (2005) · PubMed · Cited by 113 · see citing works
Peroxisome proliferator-activated receptors and cardiovascular remodeling
Schiffrin, E. L. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00677.2004 · Cited by 110 · see citing works
Regulation of inflammation by PPARs: a future approach to treat lung inflammatory diseases?
Becker, J., Delayre‐Orthez, C., Frossard, N., & Pons, F. (2006) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2006.00425.x · Cited by 109 · see citing works
Roles of PPARs on regulating myocardial energy and lipid homeostasis
Yang, Q., & Li, Y. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0170-9 · Cited by 107 · see citing works
PPARγ as a therapeutic target in central nervous system diseases
Sundararajan, S. S., Jiang, Q., Heneka, M. T., & Landreth, G. E. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.03.020 · Cited by 107 · see citing works
The effects of PPAR-? ligand pioglitazone on platelet aggregation and arterial thrombus formation
LI, D., CHEN, K., SINHA, N., ZHANG, X., Wang, Y., SINHA, A., Romeo, F., & Mehta, J. L. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.11.027 · Cited by 105 · see citing works
Ito, H., Nakano, A., Kinoshita, M., & Matsumori, A. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000106724.29121.da · Cited by 104 · see citing works
15-Deoxy-Δ12,14-prostaglandin J2-induced apoptosis does not require PPARγ in breast cancer cells
Clay, C. E., Monjazeb, A., Thorburn, J., Chilton, F. H., & High, K. P. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200224-jlr200 · Cited by 103 · see citing works
The potential effects of anti-diabetic medications on myocardial ischemia–reperfusion injury
Ye, Y., Perez-Polo, J. R., Aguilar, D. A., & Birnbaum, Y. (2011) · Basic Research in Cardiology · doi:10.1007/s00395-011-0216-6 · Cited by 100 · see citing works
Everaert, B., Craenenbroeck, E. M. V., Hoymans, V. Y., Haine, S. E. F., Nassauw, L. V., Conraads, V. M., Timmermans, J., & Vrints, C. J. (2010) · International Journal of Cardiology · doi:10.1016/j.ijcard.2010.04.018 · Cited by 99 · see citing works
Cuzzocrea, S., Pisano, B., Dugo, L., Ianaro, A., Patel, N. S. A., Paola, R. D., Genovese, T., Chatterjee, P. K., Rosa, M. D., Caputi, A. P., et al. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705419 · Cited by 99 · see citing works
Coort, S. L., Bonen, A., Vusse, G. J., Glatz, J. F. C., & Luiken, J. J. F. P. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-9030-5 · Cited by 99 · see citing works
Wu, J., Lin, T., & Wu, K. K. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21730 · Cited by 99 · see citing works
Läutamaki, R., Airaksinen, J. K. E., Seppänen, M., Toikka, J., Luotolahti, M., Ball, E., Borra, R., Härkönen, R., Iozzo, P., Stewart, M. W., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2787 · Cited by 98 · see citing works
Rosiglitazone Reduces the Development and Rupture of Experimental Aortic Aneurysms
Jones, A., Deb, R., Torsney, E., Howe, F. A., Dunkley, M., Gnaneswaran, Y., Gaze, D. C., Nasr, H. H., Loftus, I. M., Thompson, M. M., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.852467 · Cited by 97 · see citing works
Are targeted therapies for diabetic cardiomyopathy on the horizon?
Tate, M., Grieve, D., & Ritchie, R. H. (2017) · Clinical Science · doi:10.1042/cs20160491 · Cited by 95 · see citing works
Dutka, D. P., Pitt, M., Pagano, D., Mongillo, M., Gathercole, D., Bonser, R. S., & Camici, P. G. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.06.078 · Cited by 96 · see citing works
Wang, C., Weisel, R. D., Liu, P. P., Fedak, P. W. M., & Verma, S. (2003) · Circulation · doi:10.1161/01.cir.0000054675.30348.9a · Cited by 94 · see citing works
Villegas, I., Martín, A. R., Toma, W., & Alarcón‐de‐la‐Lastra, C. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.10.020 · Cited by 93 · see citing works
Kim, B., Sullivan, K. A., Backus, C., & Feldman, E. L. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3816 · Cited by 93 · see citing works
Lee, W. S., & Kim, J. (2015) · PPAR Research · doi:10.1155/2015/271983 · Cited by 93 · see citing works
Chu, K., Lee, S., Koo, J.-S., Jung, K., Kim, E., Sinn, D.-I., Kim, J., Ko, S., Kim, S., Song, E.-C., et al. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.114 · Cited by 92 · see citing works
Gruden, G., Setti, G., Hayward, A. E., Sugden, D., Duggan, S., Burt, D. J., Buckingham, R. E., Gnudi, L., & Viberti, G. C. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004030251 · Cited by 89 · see citing works
Self-citationLygate, C. A. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00289-x · Cited by 89 · see citing works
Anti-apoptotic Actions of PPAR-γ Against Ischemic Stroke
Fong, W.-H., Tsai, H., Chen, Y.-C., Wu, J., & Lin, T. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8103-y · Cited by 87 · see citing works
Review: PPARs as new therapeutic targets for the treatment of cerebral ischemia/reperfusion injury
Collino, M., Patel, N. S. A., & Thiemermann, C. (2008) · Therapeutic Advances in Cardiovascular Disease · doi:10.1177/1753944708090924 · Cited by 86 · see citing works
Morrison, A., Yan, X., Tong, C., & Li, J. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00137.2011 · Cited by 87 · see citing works
Xu, D., Murakoshi, N., Igarashi, M., Hirayama, A., Ito, Y., Seo, Y., Tada, H., & Aonuma, K. (2011) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2011.02186.x · Cited by 84 · see citing works
Pershadsingh, H. A. (2004) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.13.3.215 · Cited by 83 · see citing works
Plutzky, J., Viberti, G. C., & Haffner, S. M. (2002) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(02)00202-7 · Cited by 81 · see citing works
Peroxisome Proliferator-Activated Receptor .GAMMA. and Cardiovascular Diseases
Takano, H., & Komuro, I. (2009) · Circulation Journal · doi:10.1253/circj.cj-08-1071 · Cited by 80 · see citing works
Thiazolidinediones, peripheral oedema and congestive heart failure: what is the evidence?
Patel, C. B., Wyne, K. L., & McGuire, D. K. (2005) · Diabetes and Vascular Disease Research · doi:10.3132/dvdr.2005.010 · Cited by 78 · see citing works
Huang, P., Sata, M., Nishimatsu, H., Sumi, M., Hirata, Y., & Nagai, R. (2007) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2007.06.014 · Cited by 76 · see citing works
PPAR-γ and AMPK – Advantageous targets for myocardial ischemia/reperfusion therapy
Morrison, A., & Li, J. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.04.004 · Cited by 75 · see citing works
Chatterjee, P. K. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.10.024 · Cited by 74 · see citing works
Ye, Y., Lin, Y., Atar, S., Huang, M.-H., Perez-Polo, J. R., Uretsky, B. F., & Birnbaum, Y. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00096.2006 · Cited by 74 · see citing works
Combined Thiazolidinedione-Insulin Therapy
Scheen, A. J. (2004) · Drug Safety · doi:10.2165/00002018-200427120-00002 · Cited by 73 · see citing works
Wong, T. Y.-H., Szeto, C., Chow, K., Leung, C. B., Lam, C. W.-K., & Li, P. K. (2005) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.06.020 · Cited by 72 · see citing works
Molavi, B., Chen, J., & Mehta, J. L. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00926.2005 · Cited by 72 · see citing works
Self-citationThiazolidinediones ? some recent developments
Stümvoll, M. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.7.1179 · Cited by 71 · see citing works
Yue, T., Nerurkar, S. S., Bao, W., Jucker, B. M., Sarov‐Blat, L., Steplewski, K. M., Ohlstein, E. H., & Willette, R. N. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.135327 · Cited by 68 · see citing works
Self-citationPPARs as therapeutic targets in cardiovascular disease
van Bilsen, M., & van Nieuwenhoven, F. A. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.512917 · Cited by 68 · see citing works
Gonon, A. T., Bulhak, A., Labruto, F., Sjöquist, P.-O. B., & Pernow, J. (2006) · Basic Research in Cardiology · doi:10.1007/s00395-006-0613-4 · Cited by 67 · see citing works
PPAR-γ as a therapeutic target in cardiovascular disease: evidence and uncertainty
Huang, J. V., Greyson, C. R., & Schwartz, G. G. (2012) · Journal of Lipid Research · doi:10.1194/jlr.r024505 · Cited by 67 · see citing works
Kelly, D. P. (2003) · Circulation Research · doi:10.1161/01.res.0000064382.46274.95 · Cited by 66 · see citing works
- Authors
- Yue, T.-L., Chen, J., Bao, W., Narayanan, P. K., Bril, A., Jiang, W., Lysko, P. G., Gu, J.-L., Boyce, R., Zimmerman, D. M., Hart, T. K., Buckingham, R. E., & Ohlstein, E. H.
- Affiliations
- From the Departments of Cardiovascular Pharmacology (T.Y., J.C., W.B., A.B., W.J., P.G.L., J.G., R.E.B., E.H.O.) and Safety Assessment (P.K.N., R.B., D.M.Z., T.K.H.), GlaxoSmithKline Pharmaceuticals, King of Prussia, Pa.
- GlaxoSmithKline (United States) (US)
- GlaxoSmithKline (United Kingdom) (GB)
- Venue
- Circulation
- Published
- 2001-11-20
- Volume
- 104
- Issue
- 21
- Pages
- 2588-2594
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2102772338
- Cited by
- 295
- References
- 32
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 6 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 9 · 2014: 9 · 2013: 11 · 2012: 14
- FWCI
- 17.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- rosiglitazone, PPARγ agonists, myocardial ischemia-reperfusion injury, myocardial infarction, cardioprotection, infarct size, myocardial contractile dysfunction, neutrophil accumulation, macrophage accumulation, leukocyte adhesion molecules, CD11b/CD18, L-selectin, ICAM-1, MCP-1, inflammation, diabetes mellitus, acute myocardial infarction
- MeSH terms
- Rosiglitazone, Animals, Hypoglycemic Agents, Macrophages, Male, Monocytes, Myocardial Contraction, Myocardial Infarction, Neutrophils, Rats, Inbred Lew, RNA, Messenger, Thiazoles, Transcription Factors, Myocardial Reperfusion Injury, Cell Adhesion Molecules, Macrophage-1 Antigen, Receptors, Cytoplasmic and Nuclear, CD18 Antigens, Chemokine CCL2, Neutrophil Infiltration, Thiazolidinediones, Diabetes Complications, Rats
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