The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Differential Expression of Bone Matrix Regulatory Proteins in Human Atherosclerotic Plaques
Open accessAbstract
In the present study, we examined the expression of regulators of bone formation and osteoclastogenesis in human atherosclerosis because accumulating evidence suggests that atherosclerotic calcification shares features with bone calcification. The most striking finding of this study was the constitutive immunoreactivity of matrix Gla protein, osteocalcin, and bone sialoprotein in nondiseased aortas and the absence of bone morphogenetic protein (BMP)-2, BMP-4, osteopontin, and osteonectin in nondiseased aortas and early atherosclerotic lesions. When atherosclerotic plaques demonstrated calcification or bone formation, BMP-2, BMP-4, osteopontin, and osteonectin were upregulated. Interestingly, this upregulation was associated with a sustained immunoreactivity of matrix Gla protein, osteocalcin, and bone sialoprotein. The 2 modulators of osteoclastogenesis (osteoprotegerin [OPG] and its ligand, OPGL) were present in the nondiseased vessel wall and in early atherosclerotic lesions. In advanced calcified lesions, OPG was present in bone structures, whereas OPGL was only present in the extracellular matrix surrounding calcium deposits. The observed expression patterns suggest a tight regulation of the expression of bone matrix regulatory proteins during human atherogenesis. The expression pattern of both OPG and OPGL during atherogenesis might suggest a regulatory role of these proteins not only in osteoclastogenesis but also in atherosclerotic calcification.
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OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
Cited by
Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280
Theoleyre, S., Wittrant, Y., Tat, S. K., Fortun, Y., Redini, F., & Heymann, D. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.06.004 · Cited by 663
Shear Stress–Initiated Signaling and Its Regulation of Endothelial Function
Zhou, J., Li, Y.-S., & Chien, S. (2014) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.114.303422 · Cited by 561
Bennett, B. J., Scatena, M., Kirk, E. A., Rattazzi, M., Varon, R. M., Averill, M., Schwartz, S. M., Giachelli, C. M., & Rosenfeld, M. E. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000236428.91125.e6 · Cited by 304
Osteoprotegerin Inhibits Vascular Calcification Without Affecting Atherosclerosis in ldlr (−/−) Mice
Morony, S., Tintut, Y., Zhang, Z., Cattley, R. C., Van, G., Dwyer, D., Stolina, M., Kostenuik, P. J., & Demer, L. L. (2008) · Circulation · doi:10.1161/circulationaha.107.707380 · Cited by 258
Metadata
- Authors
- Dhore, C. R., Cleutjens, J. P. M., Lutgens, E., Cleutjens, K. B. J. M., Geusens, P. P. M., Kitslaar, P. J. E. H. M., Tordoir, J. H. M., Spronk, H. M. H., Vermeer, C., & Daemen, M. J. A. P.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2001-12
- Volume
- 21
- Issue
- 12
- Pages
- 1998-2003
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2081291016
- Cited by
- 708
- References
- 1
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- green
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- Dhore, C. R., Cleutjens, J. P. M., Lutgens, E., Cleutjens, K. B. J. M., Geusens, P. P. M., Kitslaar, P. J. E. H. M., Tordoir, J. H. M., Spronk, H. M. H., Vermeer, C., & Daemen, M. J. A. P. (2001). Differential Expression of Bone Matrix Regulatory Proteins in Human Atherosclerotic Plaques. Arteriosclerosis, Thrombosis, and Vascular Biology. https://doi.org/10.1161/hq1201.100229
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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