The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Shear Stress–Initiated Signaling and Its Regulation of Endothelial Function
Open accessAbstract
Atherosclerosis develops preferentially at branches and curvatures of the arterial tree, where blood flow pattern is disturbed rather than being laminar, and wall shear stress has an irregular distribution without defined directions. The endothelium in the atherosusceptible regions, in comparison to that in atheroresistant regions, shows activation of proproliferative and proinflammatory gene expressions, reduced production of nitric oxide (NO), increased leukocyte adhesion, and permeability, as well as other atheroprone phenotypes. Differences in gene expressions and cell phenotypes have been detected in endothelia residing in native atherosusceptible and atheroresistant regions of the arteries, or in arteries from animal models with artificial creation of disturbed flow. Similar results have also been shown in in vitro systems that apply controlled shear stresses with or without clear directions to cultured endothelial cells in fluid-dynamically designed flow-loading devices. The available evidence indicates that the coordination of multiple signaling networks, rather than individual separate pathways, links the mechanical signals to specific genetic circuitries in orchestrating the mechanoresponsive networks to evoke comprehensive genetic and functional responses.
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Cites
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Recent insights into the cellular biology of atherosclerosis
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Endothelial cation channel PIEZO1 controls blood pressure by mediating flow-induced ATP release
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Cell Type-Specific Roles of NF-κB Linking Inflammation and Thrombosis
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Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise
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Endothelial Dysfunction in Hypertension: Current Concepts and Clinical Implications
Gallo, G., Volpe, M., & Savoia, C. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.798958 · Cited by 446
Metadata
- Authors
- Zhou, J., Li, Y.-S., & Chien, S.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2014-10
- Volume
- 34
- Issue
- 10
- Pages
- 2191-2198
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2074249358
- Cited by
- 561
- References
- 87
- FWCI
- 12.19
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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