The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Periodontal Infection Is Associated With Endothelial Dysfunction in Healthy Subjects and Hypertensive Patients
Open accessAbstract
The purpose of this study was to evaluate endothelial function in patients with periodontitis. We evaluated forearm blood flow responses to acetylcholine and sodium nitroprusside in patients with periodontitis who had no other cardiovascular risk factors (32 men; 25±3 years of age), in a normal control group (20 men; 26±3 years of age), and in hypertensive patients with periodontitis (28 men and 10 women; 56±12 years of age) and without periodontitis (control group; 18 men and 6 women; 54±13 years of age). Forearm blood flow was measured using strain-gauge plethysmography. Circulating levels of C-reactive protein and interleukin-6 were significantly higher in the periodontitis group than in the control group. Both in healthy and hypertensive subjects, forearm blood flow responses to acetylcholine were significantly smaller in the periodontitis group than in the control group. Sodium nitroprusside–stimulated vasodilation was similar in the 2 groups. Periodontal therapy reduced serum concentrations of C-reactive protein and interleukin-6 and augmented acetylcholine-induced vasodilation in periodontitis patients with and without hypertension. After administration of N G -monomethyl- l -arginine, an NO synthase inhibitor, forearm blood flow response to acetylcholine was similar before and after treatment. These findings suggest that periodontitis is associated with endothelial dysfunction in subjects without cardiovascular risk factors, as well as hypertensive patients, through a decrease in NO bioavailability and that systemic inflammation may be, at least in part, a cause of endothelial dysfunction, leading to cardiovascular diseases.
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“As a result, increases in proinflammatory cytokines (2, 6), periodontal bacteria (7), and uncontrolled production of nitric oxide (NO) (2, 8) are seen in the vascular system which can lead to detrimental structural and functional changes throughout the body.”
From Oral inflammatory load predicts vascular function in a young adult population: a pilot study (2023) · cites this paper as [2]
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“Many studies have provided associations between progressed periodontal disease and vascular function (2, 6–8, 20, 21, 32), however the effect of mild gingival inflammation has been inconclusive (3, 13, 33, 34, 38).”
From Oral inflammatory load predicts vascular function in a young adult population: a pilot study (2023) · cites this paper as [2]
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“the presence of periodontitis has been shown to be associated with the development of cardiovascular diseases (CVD) such as myocardial infarction and stroke (2–5).”
From Oral inflammatory load predicts vascular function in a young adult population: a pilot study (2023) · cites this paper as [2]
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Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
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Ross, R. (1986) · New England Journal of Medicine · doi:10.1056/nejm198602203140806 · Cited by 4,885
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Cai, H., & Harrison, D. G. (2000) · Circulation Research · doi:10.1161/01.res.87.10.840 · Cited by 3,839
Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension
Panza, J. A., Quyyumi, A. A., Brush, J. E., & Epstein, S. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007053230105 · Cited by 2,366
Effect of Exercise on Coronary Endothelial Function in Patients with Coronary Artery Disease
Hambrecht, R., Wolf, A., Gielen, S., Linke, A., Hofer, J., Erbs, S., Schoene, N., & Schuler, G. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002173420702 · Cited by 1,340
The pathogenesis of atherosclerosis
(1972) · American Heart Journal · doi:10.1016/0002-8703(72)90090-7 · Cited by 1,329
Treatment of periodontitis and endothelial function
Tonetti, M. S., D'Aiuto, F., Nibali, L., Donald, A., Storry, C., Parkar, M., Suvan, J., Hingorani, A. D., Vallance, P., & Deanfield, J. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa063186 · Cited by 1,326
Dental disease and risk of coronary heart disease and mortality.
Destefano, F. R., Anda, R. F., Kahn, H. S., Williamson, D. F., & Russell, C. M. (1993) · BMJ · doi:10.1136/bmj.306.6879.688 · Cited by 1,113
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Oral inflammatory load predicts vascular function in a young adult population: a pilot study
Hong, K.-Y., Ghafari, A., Mei, Y., Williams, J. S., Attia, D., Forsyth, J., Wang, K., Wyeld, T., Sun, C., Glogauer, M., et al. (2023) · Frontiers in Oral Health · doi:10.3389/froh.2023.1233881 · Cited by 5
“After resting for 10 min, a pressure-sensing tonometer (Millar Instruments) was placed against two arterial sites: (1) carotid pulse (neck), and (2) femoral pulse (inner”
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Metadata
- Authors
- Higashi, Y., Goto, C., Jitsuiki, D., Umemura, T., Nishioka, K., Hidaka, T., Takemoto, H., Nakamura, S., Soga, J., Chayama, K., Yoshizumi, M., & Taguchi, A.
- Affiliations
- Hiroshima University (JP)
- ORCID
- Venue
- Hypertension
- Published
- 2008-02
- Volume
- 51
- Issue
- 2
- Pages
- 446-453
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2104838871
- Semantic Scholar
- 6f5420d53d2c84234d51e3e2fb6b9f55287e8dfb
- Cited by
- 250
- References
- 29
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 8 · 2023: 8 · 2022: 14 · 2021: 25 · 2020: 19 · 2019: 13 · 2018: 14 · 2017: 11 · 2016: 13 · 2015: 17 · 2014: 14 · 2013: 17 · 2012: 20
- FWCI
- 9.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- periodontitis, endothelial dysfunction, acetylcholine-induced vasodilation, sodium nitroprusside, forearm blood flow, C-reactive protein, interleukin-6, systemic inflammation, nitric oxide bioavailability, L-NMMA, periodontal treatment, cardiovascular risk
- MeSH terms
- Acetylcholine, Adult, Aged, C-Reactive Protein, Endothelium, Vascular, Enzyme Inhibitors, Female, Forearm, Humans, Hypertension, Infections, Male, Middle Aged, Nitroprusside, Osmolar Concentration, Periodontitis, Regional Blood Flow, Vasodilation, Vasodilator Agents, Interleukin-6, Nitric Oxide Synthase, omega-N-Methylarginine
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