The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Relation of Brachial and Digital Measures of Vascular Function in the Community: The Framingham Heart Study
Open accessAbstract
Impaired vascular function contributes to the development of clinical cardiovascular disease. The relation between vasodilator function assessed noninvasively in the brachial and digital arteries remains incompletely defined. In the Framingham Offspring, Third Generation and Omni Cohorts, we measured flow-mediated dilation (FMD; n=7031; age 48±13 years; age range, 19 to 88 years; 54% women) and peripheral arterial tonometry (PAT) ratio (n=4352; 55±16 years; age range, 19 to 90 years; 51% women). Abnormal vascular function for each measure was defined by the sex-specific fifth percentile in a reference group free of conventional cardiovascular risk factors. The prevalence of abnormal FMD but not abnormal PAT ratio was higher with advancing age. In multivariable models, higher body mass index was associated with a higher prevalence of both abnormal FMD and PAT ratio. Additional correlates of abnormal FMD included increasing age and higher systolic blood pressure. In contrast, correlates of abnormal PAT ratio included lower systolic blood pressure, increasing total/high-density lipoprotein cholesterol ratio, diabetes, smoking, and lipid-lowering medication. Whereas women had higher FMD and PAT ratios compared with men, using sex-specific reference values, women had a higher prevalence of abnormal brachial and digital vascular function. In participants who had concurrent testing (n=1843), PAT ratio was not significantly associated with FMD in multivariable models. In this large, community-based cohort, brachial and digital measures of vascular function had differing relations with cardiovascular risk factors and were nearly uncorrelated with each other. These results suggest that FMD and PAT provide distinct information regarding vascular function in conduit versus smaller digital vessels.
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Citations
Cites
The clinical implications of endothelial dysfunction
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“In a subgroup of Third Generation participants who had concurrent brachial and digital measurement of vascular function, we estimated partial correlations between FMD and PAT ratio accounting for (1) age and sex; and (2) age, sex, systolic blood pressure, diastolic blood pressure, heart rate, BMI, total to HDL cholest…”
MethodSelf-citationAN INVESTIGATION OF CORONARY HEART DISEASE IN FAMILIES
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Self-citationThe Framingham Offspring Study
Allhoff, P., Laaser, U., & Heinrich, J. (1991) · Kompendium der Lipid-Studien · doi:10.1007/978-3-642-95642-3_25 · Cited by 831
Assessment of peripheral vascular endothelial function with finger arterial pulse wave amplitude
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Hamburg, N. M., Keyes, M. J., Larson, M. G., Vasan, R. S., Schnabel, R., Pryde, M. M., Mitchell, G. F., Sheffy, J., Vita, J. A., & Benjamin, E. J. (2008) · Circulation · doi:10.1161/circulationaha.107.748574 · Cited by 692
Self-citationRubinshtein, R., Kuvin, J. T., Soffler, M., Lennon, R. J., Lavi, S., Nelson, R. E., Pumper, G. M., Lerman, L. O., & Lerman, A. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq010 · Cited by 683
Cited by
Vlachopoulos, C., Xaplanteris, P., Aboyans, V., Brodmann, M., Cífková, R., Cosentino, F., De Carlo, M., Gallino, A., Landmesser, U., Laurent, S., et al. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.05.007 · Cited by 716
Endothelial dysfunction and cardiovascular disease
Jay Widmer, R., & Lerman, A. (2014) · Global Cardiology Science and Practice · doi:10.5339/gcsp.2014.43 · Cited by 356
Does obstructive sleep apnea cause endothelial dysfunction? A critical review of the literature
Hoyos, C. M., Melehan, K. L., Liu, P. Y., Grunstein, R. R., & Phillips, C. L. (2015) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.06.003 · Cited by 142
Aging Biomarker Consortium, Zhang, L., Guo, J., Liu, Y., Sun, S., Liu, B., Yang, Q., Tao, J., Tian, X.-L., Pu, J., et al. (2023) · Life Medicine · doi:10.1093/lifemedi/lnad033 · Cited by 60
Lam, J. C. M., Lai, A. Y. K., Tam, T. C. C., Yuen, M. M. A., Lam, K. S. L., & Ip, M. S. M. (2017) · Sleep and Breathing · doi:10.1007/s11325-016-1428-7 · Cited by 50
Metadata
- Authors
- Hamburg, N. M., Palmisano, J., Larson, M. G., Sullivan, L. M., Lehman, B. T., Vasan, R. S., Levy, D., Mitchell, G. F., Vita, J. A., & Benjamin, E. J.
- Venue
- Hypertension
- Published
- 2011-03
- Volume
- 57
- Issue
- 3
- Pages
- 390-396
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W1985757967
- Cited by
- 364
- References
- 28
- FWCI
- 20.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hamburg, N. M., Palmisano, J., Larson, M. G., Sullivan, L. M., Lehman, B. T., Vasan, R. S., Levy, D., Mitchell, G. F., Vita, J. A., & Benjamin, E. J. (2011). Relation of Brachial and Digital Measures of Vascular Function in the Community: The Framingham Heart Study. Hypertension. https://doi.org/10.1161/hypertensionaha.110.160812
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
