The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Blood Pressure and Obesity Exert Independent Influences on Pulse Wave Velocity in Youth
Open accessAbstract
The objective was to analyze pulse wave velocity (PWV) in normotensive, high-normal, and hypertensive youths by using aortic-derived parameters from peripheral recordings. The impact of obesity on vascular phenotypes was also analyzed. A total of 501 whites from 8 to 18 years of age were included. The subjects were divided according to BP criteria: 424 (85%) were normotensive, 56 (11%) high-normal, and 21 (4%) hypertensive. Obesity was present in 284 (56%) and overweight in 138 (28%). Pulse wave analysis using a SphygmoCor device was performed to determine central blood pressure (BP), augmentation index, and measurement of PWV. Among the BP groups, differences appeared in age, sex, and height but not in body mass index. Significant differences in peripheral and central systolic and diastolic BPs and pulse pressures were observed within groups. A graded increase in PWV was present across the BP strata without differences in augmentation index. Using a multiple regression analysis, age, BP groups, and obesity status were independently associated with PWV. Older and hypertensive subjects had the highest PWV, whereas, from normal weight status to obesity, PWV decreased. Likewise, PWV was positively related to peripheral or central systolic BP and negatively related to body mass index z score. For 1 SD of peripheral systolic BP, PWV increased 0.329 m/s, and for 1 SD of body mass index z score PWV decreased 0.129 m/s. In conclusion, PWV is increased in hypertensive and even in high-normal children and adolescents. Furthermore, obesity, the factor most frequently related to essential hypertension in adolescents, blunted the expected increment in PWV of hypertensive and high-normal subjects.
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“Importantly, obesity-associated vascular changes can be reversed by weight loss even after their establishment (11;69).”
From Obesity-Associated Hypertension: Recent Progress in Deciphering the Pathogenesis (2014) · cites this paper as [69]
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Cole, T. J. (2000) · BMJ · doi:10.1136/bmj.320.7244.1240 · Cited by 16,588
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The Reference Values for Arterial Stiffness' Collaboration (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq165 · Cited by 2,085
Aortic Stiffness Is an Independent Predictor of Primary Coronary Events in Hypertensive Patients
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Obesity Hypertension in Children
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Underdiagnosis of Hypertension in Children and Adolescents
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Lurbe, E., Cífková, R., Cruickshank, J. K., Dillon, M. J., Ferreira, I., Invitti, C., Kuznetsova, T., Laurent, S., Mancia, G., Morales‐Olivas, F. J., et al. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32832f4f6b · Cited by 778
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Flynn, J. T., Kaelber, D. C., Baker-Smith, C. M., Blowey, D., Carroll, A. E., Daniels, S. R., de Ferranti, S. D., Dionne, J. M., Falkner, B., Flinn, S. K., et al. (2017) · Pediatrics · doi:10.1542/peds.2017-1904 · Cited by 3,651
Recommendations for Improving and Standardizing Vascular Research on Arterial Stiffness
Townsend, R. R., Wilkinson, I. B., Schiffrin, E. L., Avolio, A. P., Chirinos, J. A., Cockcroft, J. R., Heffernan, K. S., Lakatta, E. G., McEniery, C. M., Mitchell, G. F., et al. (2015) · Hypertension · doi:10.1161/hyp.0000000000000033 · Cited by 1,527
Update: Ambulatory Blood Pressure Monitoring in Children and Adolescents
Flynn, J. T., Daniels, S. R., Hayman, L. L., Maahs, D. M., McCrindle, B. W., Mitsnefes, M. M., Zachariah, J. P. V., & Urbina, E. M. (2014) · Hypertension · doi:10.1161/hyp.0000000000000007 · Cited by 608
Childhood Obesity and Cardiovascular Dysfunction
Coté, A. T., Harris, K. C., Panagiotopoulos, C., Sandor, G. G. S., & Devlin, A. M. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.07.042 · Cited by 456
Obesity and Arterial Stiffness in Children
Coté, A. T., Phillips, A. A., Harris, K. C., Sandor, G. G. S., Panagiotopoulos, C., & Devlin, A. M. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.305062 · Cited by 161
Metadata
- Authors
- Lurbe, E., Torro, I., Garcia-Vicent, C., Alvarez, J., Fernández-Fornoso, J. A., & Redon, J.
- Affiliations
- Universitat de València (ES)
- From the Pediatric Department, Consorcio Hospital General (E.L., I.T., C.G.-V., J.A.) and Hypertension Clinic, Hospital Clinico, INCLIVA (J.R.), University of Valencia, Valencia, Spain; CIBER Fisiopatología Obesidad y Nutrición (E.L., I.T., J.A., J.A.F.-F., J.R.), Instituto de Salud Carlos III, Madrid, Spain.
- ORCID
- Lurbe, Empar
- Venue
- Hypertension
- Published
- 2012-08
- Volume
- 60
- Issue
- 2
- Pages
- 550-555
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2135808527
- Cited by
- 150
- References
- 31
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 4 · 2023: 15 · 2022: 13 · 2021: 10 · 2020: 15 · 2019: 7 · 2018: 18 · 2017: 8 · 2016: 13 · 2015: 15 · 2014: 12 · 2013: 8 · 2012: 4
- FWCI
- 8.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- pulse wave velocity, obesity, pediatric hypertension, high-normal blood pressure, central blood pressure, augmentation index, body mass index, vascular stiffness, adolescents, essential hypertension, pulse pressure
- MeSH terms
- Adolescent, Age Factors, Blood Pressure, Child, Female, Humans, Hypertension, Male, Obesity, Pulsatile Flow, Regression Analysis, Body Mass Index, Overweight
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