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Cited by 1,493Cardiovascular Health and Disease PreventionCardiovascular Function and Risk FactorsBlood Pressure and Hypertension Studies

Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients

Blacher, Jacques, Asmar, Roland, Djane, Saliha, London, Gérard M., Safar, Michel E.·1999·Hypertension
DOI 10.1161/01.hyp.33.5.1111
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Abstract

Large artery damage is a major contributory factor to cardiovascular morbidity and mortality of patients with hypertension. Pulse wave velocity (PWV), a classic evaluation of arterial distensibility, has never been ascertained as a cardiovascular risk marker. To determine the factors influencing aortic PWV and the potential predictor role of this measurement, we studied a cohort of 710 patients with essential hypertension. Atherosclerosis alterations (AA) were defined on the basis of clinical events. Calculation of cardiovascular risks, by use of Framingham equations, was performed in subjects without AA. PWV was higher in the presence of AA (14.9+/-4.0 versus 12.4+/-2.6 m/s, P<0.0001), even after adjustments on confounding factors and was the first determinant (P<0.0001) of the extent of atherosclerosis assessed as the sum of the atherosclerotic sites. In patients without AA, all cardiovascular risks increased constantly with PWV. Furthermore, at a given age, aortic PWV was the best predictor of cardiovascular mortality. The odds ratio of being in a high cardiovascular mortality risk group (>5% for 10 years) for patients in the upper quartile of PWV was 7.1 (95% confidence intervals 4.5 to 11.3). The presence of a PWV >13 m/s, taken alone, appeared as a strong predictor of cardiovascular mortality with high performance values. This study shows that aortic PWV is strongly associated with the presence and extent of atherosclerosis and constitutes a forceful marker and predictor of cardiovascular risk in hypertensive patients.

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  • Aortic PWV is an independent risk factor for cardiovascular and all-cause mortality in hypertension and in renal disease.

    “there is increasing evidence that aortic PWV is an independent risk factor for cardiovascular and all-cause mortality in hypertension 19,20 and in renal disease. 21”

    From Acute Effect of Caffeine on Arterial Stiffness and Aortic Pressure Waveform (2001) · cites this paper as [19]

  • Large-artery stiffness and wave reflections have been identified as markers of cardiovascular disease and independent prognosticators of cardiovascular risk.

    “Large-artery stiffness and wave reflections are important determinants of left ventricular (LV) function, coronary blood flow, and mechanical integrity of arteries and have been identified as markers of cardiovascular disease and independent prognosticators of cardiovascular risk (4 -12).”

    From Smoking and caffeine have a synergistic detrimental effect on aortic stiffness and wave reflections (2004) · cites this paper as [8]

  • Large-artery stiffness and wave reflections are important determinants of left ventricular function, coronary blood flow, and mechanical integrity of arteries.

    “Large-artery stiffness and wave reflections are important determinants of left ventricular (LV) function, coronary blood flow, and mechanical integrity of arteries and have been identified as markers of cardiovascular disease and independent prognosticators of cardiovascular risk (4 -12).”

    From Smoking and caffeine have a synergistic detrimental effect on aortic stiffness and wave reflections (2004) · cites this paper as [8]

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Authors
Blacher, J., Asmar, R., Djane, S., London, G. M., & Safar, M. E.
Affiliations
  • Inserm (FR)
  • From the Department of Internal Medicine and Inserm U 337, Broussais Hospital, Paris, France.
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1999-05
Volume
33
Issue
5
Pages
1111-1117
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/01.hyp.33.5.1111
OpenAlex
W2141870462
Cited by
1,493
References
26
Citations by year
2026: 19 · 2025: 14 · 2024: 24 · 2023: 20 · 2022: 30 · 2021: 46 · 2020: 35 · 2019: 41 · 2018: 49 · 2017: 53 · 2016: 83 · 2015: 88 · 2014: 81 · 2013: 63 · 2012: 71
FWCI
28.45
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
aortic pulse wave velocity, essential hypertension, cardiovascular risk prediction, cardiovascular mortality, atherosclerosis, arterial stiffness, Framingham risk score, arterial distensibility
MeSH terms
Age Factors, Aged, Aorta, Arteriosclerosis, Blood Glucose, Cardiovascular Diseases, Cholesterol, Creatinine, Female, Humans, Hypertension, Cholesterol, HDL, Male, Middle Aged, Pulse, Risk Factors, ROC Curve, Smoking, Time Factors, Cohort Studies, Biomarkers, Confidence Intervals, Odds Ratio, Hypertrophy, Left Ventricular

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