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Cited by 144Sleep and related disordersObstructive Sleep Apnea ResearchSleep and Work-Related Fatigue

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Insomnia With Physiological Hyperarousal Is Associated With Hypertension

Li, Yun, Vgontzas, Alexandros N., Fernandez-Mendoza, Julio, Bixler, Edward O., Sun, Yuanfeng, Zhou, Junying, Ren, Rong, Li, Tao, Tang, Xiangdong·2015·Hypertension
DOI 10.1161/hypertensionaha.114.04604
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Abstract

Previous studies have suggested that insomnia with objective short sleep duration is associated with a higher risk of hypertension, and it has been speculated that the underlying mechanism is physiological hyperarousal. In this study, we tested whether insomnia with physiological hyperarousal measured by Multiple Sleep Latency Test (MSLT), a standard test of sleepiness/alertness, is associated with increased risk of hypertension. Two hundred nineteen chronic insomniacs and 96 normal sleepers were included in this study. Chronic insomnia was defined based on standard diagnostic criteria with symptoms lasting ≥6 months. All subjects underwent 1 night in laboratory polysomnography followed by a standard MSLT. We used the median mean MSLT value (ie, >14 minutes) and the 75th percentile of mean MSLT value (ie, >17 minutes) to define hyperarousal. Hypertension was defined based either on blood pressure measures or on diagnosis treatment by a physician. After controlling for age, sex, body mass index, apnea-hypopnea index, diabetes mellitus, smoking, alcohol, and caffeine use, insomnia combined with MSLT >14 minutes increased the odds of hypertension by 300% (odds ratio=3.27; 95% confidence interval=1.20-8.96), whereas insomnia combined with MSLT >17 minutes increased even further the odds of hypertension by 400% (odds ratio=4.33; 95% confidence interval=1.48-12.68) compared with normal sleepers with MSLT ≤14 minutes. Insomnia associated with physiological hyperarousal is associated with a significant risk of hypertension. Long MSLT values may be a reliable index of the physiological hyperarousal and biological severity of chronic insomnia.

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Crossref · 10.1161/hypertensionaha.114.04604

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Research works printed but not linked: 3

  1. Dupuy HJ, Engel A, Devine BK, Scanlon J, Querec L. Selected symptoms of psychological distress. Vital Health Stat 11.1970;37:1–44.
  2. Legacy DSM. NIH state-of-the-science conference statement on manifestations and management of chronic insomnia in adults. NIH Consens State Sci Statements. 2005;22:1–30.
  3. Gaines J, Fernandez-Mendoza J, Vgontzas AN, Basta M, Pejovic S, Bixler EO. Short- and long-term stability of sleep duration in insomniacs and healthy controls. Sleep 2014:208.

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Metadata

Authors
Li, Y., Vgontzas, A. N., Fernandez-Mendoza, J., Bixler, E. O., Sun, Y., Zhou, J., Ren, R., Li, T., & Tang, X.
Affiliations
  • Pennsylvania State University (US)
  • From the Sleep Medicine Center, Mental Health Center, Translational Neuroscience Center, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China (Y.L., Y.S., J.Z., R.R., T.L., X.T.) and Department of Psychiatry, Sleep Research and Treatment Center, Pennsylvania State University College of Medicine, Hershey (Y.L., A.N.V., J.F.-M., E.O.B.).
ORCID
Venue
Hypertension
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2015-03
Volume
65
Issue
3
Pages
644-650
ISSN
  • 0194-911X (ISSN-L)
  • 1524-4563
DOI
10.1161/hypertensionaha.114.04604
OpenAlex
W2096701216
Cited by
144
References
51
Citations by year
2026: 6 · 2025: 10 · 2024: 10 · 2023: 15 · 2022: 9 · 2021: 9 · 2020: 8 · 2019: 19 · 2018: 12 · 2017: 14 · 2016: 27 · 2015: 5
FWCI
29.17
Type
journal article
Language
en
Open access
closed
Locations
  • Hypertension (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
insomnia, physiological hyperarousal, multiple sleep latency test, chronic insomnia, sleepiness, alertness, blood pressure
MeSH terms
Adult, Cross-Sectional Studies, Female, Humans, Hypertension, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Risk Factors, Severity of Illness Index, Comorbidity, Case-Control Studies, Polysomnography, Sleep Arousal Disorders

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