Role of Adding Spironolactone and Renal Denervation in True Resistant Hypertension: One-Year Outcomes of Randomized PRAGUE-15 Study
Abstract
This randomized, multicenter study compared the relative efficacy of renal denervation (RDN) versus pharmacotherapy alone in patients with true resistant hypertension and assessed the effect of spironolactone addition. We present here the 12-month data. A total of 106 patients with true resistant hypertension were enrolled in this study: 52 patients were randomized to RDN and 54 patients to the spironolactone addition, with baseline systolic blood pressure of 159±17 and 155±17 mm Hg and average number of drugs 5.1 and 5.4, respectively. Twelve-month results are available in 101 patients. The intention-to-treat analysis found a comparable mean 24-hour systolic blood pressure decline of 6.4 mm Hg, P =0.001 in RDN versus 8.2 mm Hg, P =0.002 in the pharmacotherapy group. Per-protocol analysis revealed a significant difference of 24-hour systolic blood pressure decline between complete RDN (6.3 mm Hg, P =0.004) and the subgroup where spironolactone was added, and this continued within the 12 months (15 mm Hg, P = 0.003). Renal artery computed tomography angiograms before and after 1 year post-RDN did not reveal any relevant changes. This study shows that over a period of 12 months, RDN is safe, with no serious side effects and no major changes in the renal arteries. RDN in the settings of true resistant hypertension with confirmed compliance is not superior to intensified pharmacological treatment. Spironolactone addition (if tolerated) seems to be more effective in blood pressure reduction.
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Recent reports document the efficacy of mineralocorticoid receptor blockade to improve BP in patients with resistant hypertension.
“Recent reports document the efficacy of mineralocorticoid receptor blockade (Figure 3, step 3, and Table 4) to improve BP in patients with RH.373–377”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [376]
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Catheter-Based Renal Denervation for Resistant Hypertension: Will It Ever Be Ready for “Prime Time”?
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Resistant Hypertension: Questions and Contemporary Answers
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- Authors
- Rosa, J., Widimský, P., Waldauf, P., Lambert, L., Zelinka, T., Táborský, M., Branny, M., Toušek, P., Petrák, O., Čurila, K., Bednář, F., Holaj, R., Štrauch, B., Václavík, J., Nykl, I., Krátká, Z., Kociánová, E., Jiravský, O., Rappová, G., Indra, T., & Widimský, J.
- Affiliations
- University Hospital Kralovske Vinohrady (CZ)
- From the 3rd Department of Medicine, Center for Hypertension, General University Hospital and First Faculty of Medicine (J.R., T.Z., O.P., R.H., B.Š., Z.K., T.I., J.W. Jr), Cardiocentre, University Hospital Královské Vinohrady and Third Faculty of Medicine (J.R., P. Widimský, P. Toušek, K.Č., F.B.), Department of Anesthesiology, University Hospital Královské Vinohrady and Third Faculty of Medicine (P. Waldauf), and Department of Radiology, General University Hospital and First Faculty of Medicine (L...
- ORCID
- Venue
- Hypertension
- Published
- 2016-02
- Volume
- 67
- Issue
- 2
- Pages
- 397-403
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2203676237
- Cited by
- 78
- References
- 37
- Citations by year
- 2026: 1 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 12 · 2019: 12 · 2018: 12 · 2017: 17 · 2016: 13 · 2015: 1
- FWCI
- 10.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal and Vascular Pathologies
- Keywords
- resistant hypertension, renal denervation, spironolactone, blood pressure reduction, antihypertensive pharmacotherapy, renal artery, treatment efficacy comparison, medication adherence
- MeSH terms
- Angiography, Blood Pressure, Diuretics, Dose-Response Relationship, Drug, Drug Resistance, Echocardiography, Female, Follow-Up Studies, Humans, Hypertension, Kidney, Male, Middle Aged, Prospective Studies, Spironolactone, Sympathectomy, Time Factors, Tomography, X-Ray Computed, Treatment Outcome, Blood Pressure Monitoring, Ambulatory
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