Cited by 800Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac pacing and defibrillation studies

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Long-term outcomes of catheter ablation of atrial fibrillation: a systematic review and meta-analysis

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Ganesan, Anand N., Shipp, Nicholas J., Brooks, Anthony G., Kuklik, Pawel, Lau, Dennis H., Lim, Han S., Sullivan, Thomas, Roberts‐Thomson, Kurt C., Sanders, Prashanthan·2013·Journal of the American Heart Association

DOI 10.1161/jaha.112.004549PMC PMC3647286

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Abstract

BACKGROUND: In the past decade, catheter ablation has become an established therapy for symptomatic atrial fibrillation (AF). Until very recently, few data have been available to guide the clinical community on the outcomes of AF ablation at ≥3 years of follow-up. We aimed to systematically review the medical literature to evaluate the long-term outcomes of AF ablation. METHODS AND RESULTS: A structured electronic database search (PubMed, Embase, Web of Science, Cochrane) of the scientific literature was performed for studies describing outcomes at ≥3 years after AF ablation, with a mean follow-up of ≥24 months after the index procedure. The following data were extracted: (1) single-procedure success, (2) multiple-procedure success, and (3) requirement for repeat procedures. Data were extracted from 19 studies, including 6167 patients undergoing AF ablation. Single-procedure freedom from atrial arrhythmia at long-term follow-up was 53.1% (95% CI 46.2% to 60.0%) overall, 54.1% (95% CI 44.4% to 63.4%) in paroxysmal AF, and 41.8% (95% CI 25.2% to 60.5%) in nonparoxysmal AF. Substantial heterogeneity (I(2)>50%) was noted for single-procedure outcomes. With multiple procedures, the long-term success rate was 79.8% (95% CI 75.0% to 83.8%) overall, with significant heterogeneity (I(2)>50%).The average number of procedures per patient was 1.51 (95% CI 1.36 to 1.67). CONCLUSIONS: Catheter ablation is an effective and durable long-term therapeutic strategy for some AF patients. Although significant heterogeneity is seen with single procedures, long-term freedom from atrial arrhythmia can be achieved in some patients, but multiple procedures may be required.

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Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · cited 1×
“A pooled estimate of survival at 12months and the latest follow-upwas calculated, using random-effects models based on logit transformed proportions.(7) The time point of latest follow-up in a study was defined as the last time point reporting a minimum of 30 subjects at risk.”
Method
Quantifying heterogeneity in a meta‐analysis
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Method
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“C atheter ablation of atrial fibrillation (AF) has become an established therapeutic modality for the treatment of patients with symptomatic AF.(1) To date, studies reporting outcomes of AF ablation have predominantly limited follow-up to 1 to 2 years after the index ablation procedure.”
BackgroundInfluential
Guidelines for the management of atrial fibrillation
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Authors/Task Force Members, Camm, A. J., Kirchhof, P. F., Lip, G. Y. H., Schotten, U., Savelieva, I., Ernst, S., Gelder, I. C. V., Al‐Attar, N., Hindricks, G., et al. (2010) · EP Europace · doi:10.1093/europace/euq350 · Cited by 1,764
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Calkins, H. G., Kück, K., Cappato, R., Brugada, J., Camm, A. J., Chen, S., Crijns, H. J. G. M., Damiano, R. J., Davies, D. W., Dimarco, J., et al. (2012) · Journal of Interventional Cardiac Electrophysiology · doi:10.1007/s10840-012-9672-7 · Cited by 1,685

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Sartini RJ, Scanavacca MI, Sosa E, Moreira LF, Lara S, Hardy C, Darrieux F, Hachul D. Radiofrequency ablation of paroxysmal atrial fibrillation: factors determining long‐term clinical efficacy. Arq Bras Cardiol. 2008;90:112–118.

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Authors: Ganesan, A. N., Shipp, N. J., Brooks, A. G., Kuklik, P., Lau, D. H., Lim, H. S., Sullivan, T., Roberts‐Thomson, K. C., & Sanders, P.
Affiliations: Royal Adelaide Hospital (AU)
Centre for Heart Rhythm Disorders (CHRD), University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia
Corresponding author: Sanders, Prashanthan
ORCID: Ganesan, Anand N.
Lau, Dennis H.
Lim, Han S.
Sullivan, Thomas
Sanders, Prashanthan
Venue: Journal of the American Heart Association
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2013-03-12
Volume: 2
Issue: 2
Pages: e004549-e004549
ISSN: 2047-9980 (ISSN-L)
DOI: 10.1161/jaha.112.004549
PMC: PMC3647286
OpenAlex: W2165779304
Cited by: 800
References: 45
Citations by year: 2026: 43 · 2025: 36 · 2024: 62 · 2023: 61 · 2022: 63 · 2021: 65 · 2020: 76 · 2019: 77 · 2018: 74 · 2017: 75 · 2016: 60 · 2015: 53 · 2014: 43 · 2013: 11
FWCI: 9.52
Type: journal article
Language: en
Open access: gold
doi.org
Locations: Journal of the American Heart Association (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, other-oa)
Minerva Access (University of Melbourne) (submittedVersion, cc-by)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords: atrial fibrillation, catheter ablation, long-term outcomes, procedural success, repeat procedures, atrial arrhythmia recurrence, paroxysmal atrial fibrillation, non-paroxysmal atrial fibrillation
MeSH terms: Anti-Arrhythmia Agents, Atrial Fibrillation, Humans, Longitudinal Studies, Recurrence, Treatment Outcome, Catheter Ablation

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Long-term outcomes of catheter ablation of atrial fibrillation: a systematic review and meta-analysis

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