Congenital heart disease and risk of cardiovascular disease: a meta-analysis of cohort studies
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Background Despite remarkable success in the surgical and medical management of congenital heart disease ( CHD ), some survivors still experience cardiovascular complications over the long term. The goal of this study was to evaluate the association between CHD and risk of cardiovascular disease ( CVD ) by conducting a meta-analysis of cohort studies. Methods and Results A systematic literature search of several databases was conducted through April 2018 to identify studies reporting the risk of CVD , stroke, heart failure, and coronary artery heart disease in CHD survivors. The quality of individual studies was assessed using the Newcastle-Ottawa scale. The overall risk estimates were pooled using fixed-effects meta-analysis. Subgroup analyses were performed to explore possible sources of heterogeneity. Nine cohort studies comprising 684 200 participants were included. The overall combined relative risks for people with CHD compared with the controls were 3.12 (95% CI, 3.01-3.24) for CVD , 2.46 (95% CI, 2.30-2.63) for stroke, 5.89 (95% CI, 5.58-6.21) for heart failure, and 1.50 (95% CI, 1.40-1.61) for coronary artery heart disease. Significant heterogeneity was detected across studies regarding these risk estimates. Heterogeneity in the risk estimate of CVD was explained by geographic region, type of study design, sample source, age composition, and controlled confounders. Conclusions This meta-analysis of cohort studies of CHD found an association of increased risk of CVD in later life, although we cannot determine whether this association is confounded by a risk factor profile of CVD among CHD survivors or whether CHD is an independent risk factor.
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The presence of CHD may increase the likelihood of developing coronary artery disease in later life.
“However, the presence of CHD may increase the likelihood of developing coronary artery disease in later life .484”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [484]
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Clinical practice guidelines for the care of girls and women with Turner syndrome.
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- Authors
- Wang, T., Chen, L., Yang, T., Huang, P., Wang, L., Zhao, L., Zhang, S., Ye, Z., Chen, L., Zheng, Z., & Qin, J.
- Affiliations
- Central South University (CN)
- Hunan Children's Hospital (CN)
- Department of Epidemiology and Health Statistics Xiangya School of Public Health Central South University Changsha China
- Corresponding author
- Qin, Jiabi
- ORCID
- Venue
- Journal of the American Heart Association
- Published
- 2019-05-21
- Volume
- 8
- Issue
- 10
- Pages
- e012030-e012030
- ISSN
- 2047-9980 (ISSN-L)
- PMC
- PMC6585327
- OpenAlex
- W2943890763
- Cited by
- 177
- References
- 50
- Citations by year
- 2026: 21 · 2025: 23 · 2024: 35 · 2023: 28 · 2022: 32 · 2021: 27 · 2020: 7 · 2019: 3
- FWCI
- 2.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- Journal of the American Heart Association (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Keywords
- congenital heart disease, cardiovascular disease, stroke, heart failure, coronary artery disease, long-term outcomes, cardiovascular risk factors, confounding
- MeSH terms
- Age Factors, Cardiovascular Diseases, Coronary Artery Disease, Female, Heart Defects, Congenital, Heart Failure, Humans, Male, Prognosis, Risk Factors, Time Factors, Survivors, Risk Assessment, Stroke
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