Randomized, Placebo-Controlled, Clinical Trial of Donepezil in Vascular Dementia: Differential Effects by Hippocampal Size
Open accessAbstract
Background and Purpose— We sought to assess the efficacy and safety of donepezil in patients with vascular dementia (VaD) fulfilling National Institute of Neurological Disorders and Stroke–Association Internationale pour la Recherche et l’Enseignement en Neurosciences criteria. Methods— This international, multicenter, 24-week trial was conducted from March 2003 to August 2005. Patients (N=974; mean age, 73.0 years) with probable or possible VaD were randomized 2:1 to receive donepezil 5 mg/d or placebo. Coprimary outcome measures were scores on the Vascular-Alzheimer Disease Assessment Scale–Cognitive Subscale and Clinician’s Interview–Based Impression of Change, plus carer interview. Analyses were performed for the intent-to-treat population with the last-observation-carried-forward method. Results— Compared with placebo, donepezil-treated patients showed significant improvement from baseline to end point on the Vascular-Alzheimer Disease Assessment Scale–Cognitive Subscale (least-squares mean difference, −1.156; 95% CI, −1.98 to −0.33; P <0.01) but not on the Clinician’s Interview–Based Impression of Change, plus carer interview. Patients with hippocampal atrophy who were treated with donepezil demonstrated stable cognition versus a decline in the placebo-treated group; in those without atrophy, cognition improved with donepezil versus relative stability with placebo. Results on secondary efficacy measures were inconsistent. The incidence of adverse events was similar across groups. Eleven deaths occurred in the donepezil group (1.7%), similar to rates previously reported for donepezil trials in VaD, whereas no deaths occurred in the placebo group. Conclusions— Patients treated with donepezil 5 mg/d demonstrated significant improvement in cognitive, but not global, function. Donepezil was relatively well tolerated; adverse events were consistent with current labeling. Mortality in the placebo group was unexpectedly low. The differential treatment response of VaD patients by hippocampal size suggests that hippocampal imaging warrants further investigation for understanding VaD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Donepezil produced cognitive benefit in VaD, but global and functional efficacy was less consistent across individual studies.
“Cognitive benefit was found, but global and functional efficacy was less consistent in the individual studies.396,400”
Among 3 donepezil trials, all found significant benefit for cognition.
“Among the 3 trials conducted with donepezil, all found a significant benefit for cognition, 261-263”
From Vascular Cognitive Impairment (2017) · cites this paper as [263]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Collaboration, A. T. (2002) · BMJ · doi:10.1136/bmj.324.7329.71 · Cited by 6,943 · see citing works
Román, G. C., Tatemichi, T. K., Erkinjuntti, T., Cummings, J. L., Masdeu, J. C., Garcia, J. H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., et al. (1993) · Neurology · doi:10.1212/wnl.43.2.250 · Cited by 4,921 · see citing works
Self-citationA new rating scale for Alzheimer's disease
(1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.11.1356 · Cited by 4,175 · see citing works
Scheltens, P., Leys, D., Barkhof, F., Huglo, D. G., Weinstein, H. C., Vermersch, P., Kuiper, M. A., Steinling, M., Wolters, E. C., & Valk, J. (1992) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.55.10.967 · Cited by 1,781 · see citing works
A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease
Rogers, S. L., Farlow, M. R., Doody, R. S., Mohs, R., Friedhoff, L. T., & Donepezil Study Group* (1998) · Neurology · doi:10.1212/wnl.50.1.136 · Cited by 1,618 · see citing works
The way I see it: House officers need formal career development
Connor, A. (2002) · BMJ · doi:10.1136/bmj.324.7336.s71 · Cited by 1,146 · see citing works
Gélinas, I., Gauthier, L., McIntyre, M., & Gauthier, S. (1999) · American Journal of Occupational Therapy · doi:10.5014/ajot.53.5.471 · Cited by 918 · see citing works
CLOX: an executive clock drawing task
Royall, D. R., Cordes, J. A., & Polk, M. J. (1998) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.64.5.588 · Cited by 839 · see citing works
Self-citationClinical Dementia Rating (CDR)
Gauthier, S. G. (2001) · CRC Press eBooks · doi:10.3109/9780203213896-34 · Cited by 696 · see citing works
Development of Cognitive Instruments for Use in Clinical Trials of Antidementia Drugs
Mohs, R. C., Knopman, D. S., Petersen, R. C., Ferris, S. H., Ernesto, C., Grundman, M., Sano, M., Bieliauskas, L. A., Geldmacher, D., Clark, C. M., et al. (1997) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199700112-00003 · Cited by 693 · see citing works
Schneider, L., Olin, J. T., Doody, R. S., Clark, C. M., Morris, J. C., Reisberg, ., Schmitt, F. A., Grundman, M., Thomas, R. G., & Ferris, S. H. (1997) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199700112-00004 · Cited by 647 · see citing works
Bedside Assessment of Executive Cognitive Impairment: The Executive Interview
Royall, D. R., Mahurin, R. K., & Gray, K. F. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb03646.x · Cited by 595 · see citing works
Self-citationMohs, R. C., Knopman, D. S., Petersen, R. C., Ferris, S. H., Ernesto, C., Grundman, M., Sano, M., Bieliauskas, L. A., Geldmacher, D., Clark, C., et al. (1997) · PubMed · Cited by 487 · see citing works
Donepezil in vascular dementia: A randomized, placebo-controlled study
Wilkinson, D., Doody, R., Helme, R., Taubman, K., Mintzer, J., Kertesz, A., Pratt, R. D., & the Donepezil 308 Study Group* (2003) · Neurology · doi:10.1212/01.wnl.0000078943.50032.fc · Cited by 392 · see citing works
Winblad, B. G., Kilander, L., Eriksson, S., Minthon, L., Båtsman, S., Wetterholm, A.-L., Jansson-Blixt, C., & Haglund, A. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68350-5 · Cited by 388 · see citing works
Black, S., Román, G. C., Geldmacher, D. S., Salloway, S., Hecker, J., Burns, A., Perdomo, C., Kumar, D., & Pratt, R. (2003) · Stroke · doi:10.1161/01.str.0000091396.95360.e1 · Cited by 386 · see citing works
Self-citationSyncope and Its Consequences in Patients With Dementia Receiving Cholinesterase Inhibitors
Gill, S. S., Anderson, G., Fischer, H. D., Bell, C. M., Li, P., Normand, S. T., & Rochon, P. A. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.43 · Cited by 306 · see citing works
Schneider, L. S. S., Olin, J. T., Doody, R. S., Clark, C. M., Morris, J. C., Reisberg, ., Ferris, S. H., Schmitt, F. A., Grundman, M., & Thomas, R. G. (1997) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4612-4116-4_64 · Cited by 303 · see citing works
Neuropathological basis of magnetic resonance images in aging and dementia
Jagust, W. J., Zheng, L., Harvey, D. J., Mack, W. J., Vinters, H. V., Weiner, M. W., Ellis, W. G., Zarow, C., Mungas, D., Reed, B. R., et al. (2008) · Annals of Neurology · doi:10.1002/ana.21296 · Cited by 302 · see citing works
Self-citationDichgans, M., Markus, H. S., Salloway, S., Verkkoniemi, A., Moline, M., Wang, Q., Posner, H., & Chabriat, H. S. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70046-2 · Cited by 264 · see citing works
Self-citationVascular determinants of cholinergic deficits in Alzheimer disease and vascular dementia.
Román, G. C., & Kalaria, R. N. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.004 · Cited by 213 · see citing works
Galantamine treatment of vascular dementia: A randomized trial
Auchus, A. P., Brashear, H. R., Salloway, S., Korczyn, A. D., De Deyn, P. P., & Gassmann-Mayer, C. (2007) · Neurology · doi:10.1212/01.wnl.0000266625.31615.f6 · Cited by 189 · see citing works
Self-citationExecutive Control Function: A Rational Basis for the Diagnosis of Vascular Dementia
n, G. C. R., & Royall, D. R. (1999) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199912003-00012 · Cited by 172 · see citing works
Self-citationThe Physiology and Pharmacology of Melatonin in Humans
Geoffriau, M., Brun, J., Chazot, G., & Claustrat, B. (1998) · Hormone Research in Paediatrics · doi:10.1159/000023160 · Cited by 163 · see citing works
Vascular dementia revisited: Diagnosis, pathogenesis, treatment, and prevention
Román, G. C. (2002) · Medical Clinics of North America · doi:10.1016/s0025-7125(02)00008-1 · Cited by 157 · see citing works
Ballard, C., Sauter, M., Scheltens, P., He, Y., Barkhof, F., van Straaten, E. C. W., van der Flier, W. M., Hsu, C., Wu, S., & Lane, R. (2008) · Current Medical Research and Opinion · doi:10.1185/03007990802328142 · Cited by 147 · see citing works
Bastos-Leite, A. J., van der Flier, W. M., van Straaten, E. C. W., Staekenborg, S. S., Scheltens, P., & Barkhof, F. (2007) · Stroke · doi:10.1161/strokeaha.107.490102 · Cited by 128 · see citing works
Chan, M. Y., Lim, W. S., & Sahadevan, S. (2008) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000178755 · Cited by 34 · see citing works
Flagged first, then by citations
1 of the 30 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Gorelick, P. B., Scuteri, A., Black, S. E., DeCarli, C., Greenberg, S. M., Iadecola, C., Launer, L. J., Laurent, S., Lopez, O. L., Nyenhuis, D., et al. (2011) · Stroke · doi:10.1161/str.0b013e3182299496 · Cited by 3,811 · see citing works
Self-citationO'Brien, J. T., & Thomas, A. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00463-8 · Cited by 1,136 · see citing works
Review: Cerebral microvascular pathology in ageing and neurodegeneration
Brown, W. R., & Thore, C. R. (2011) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2010.01139.x · Cited by 749 · see citing works
van der Flier, W. M., Skoog, I. G., Schneider, J. A., Pantoni, L., Mok, V., Chen, C., & Scheltens, P. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.3 · Cited by 600 · see citing works
Dichgans, M., & Leys, D. (2017) · Circulation Research · doi:10.1161/circresaha.116.308426 · Cited by 581 · see citing works
Lanctôt, K. L., Lindsay, M. P., Smith, E. E., Sahlas, D. J., Foley, N. C., Gubitz, G. J., Austin, M., Ball, K., Bhogal, S. K., Blake, T. M., et al. (2019) · International Journal of Stroke · doi:10.1177/1747493019847334 · Cited by 238 · see citing works
Consensus statement for diagnosis of subcortical small vessel disease
Rosenberg, G. A., Wallin, A., Wardlaw, J. M., Markus, H. S., Montaner, J., WOLFSON, L. I., Iadecola, C., Zloković, B. V., Joutel, A., Dichgans, M., et al. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.172 · Cited by 224 · see citing works
The impact of cerebrovascular aging on vascular cognitive impairment and dementia
Yang, T., Sun, Y., Lu, Z., Leak, R. K., & Zhang, F. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.007 · Cited by 206 · see citing works
Quinn, T. J., Richard, E., Teuschl, Y., Gattringer, T., Hafdi, M., O'Brien, J. T., Merriman, N. A., Gillebert, C. R., Huygelier, H., Verdelho, A., et al. (2021) · European Journal of Neurology · doi:10.1111/ene.15068 · Cited by 190 · see citing works
Neuroscience insights improve neurorehabilitation of poststroke aphasia
Berthier, M. L., & Friedemann Pulvermüller, A. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.201 · Cited by 178 · see citing works
Knight, R., Khondoker, M. R., Magill, N., Stewart, R. J., & Landau, S. (2018) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000486546 · Cited by 162 · see citing works
Battle, C. E., Abdul‐Rahim, A. H., Shenkin, S. D., Hewitt, J., & Quinn, T. J. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013306.pub2 · Cited by 157 · see citing works
Vascular Cognitive Impairment and Dementia
Wong, E. C., & Chui, H. C. (2022) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/con.0000000000001124 · Cited by 158 · see citing works
Pharmacotherapy for Vascular Cognitive Impairment
Farooq, M. U., Min, J., Goshgarian, C., & Gorelick, P. B. (2017) · CNS Drugs · doi:10.1007/s40263-017-0459-3 · Cited by 152 · see citing works
Mixed dementia: A review of the evidence
Custodio, N., Montesinos, R., Lira, D., Herrera-Pérez, E., Bardales, Y., & Valeriano-Lorenzo, L. (2017) · Dementia & Neuropsychologia · doi:10.1590/1980-57642016dn11-040005 · Cited by 148 · see citing works
Ischemic brain injury in cerebral amyloid angiopathy
Reijmer, Y. D., van Veluw, S. J., & Greenberg, S. M. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.88 · Cited by 143 · see citing works
Age-Related White Matter Changes
Xiong, Y., & Mok, V. (2011) · Journal of Aging Research · doi:10.4061/2011/617927 · Cited by 141 · see citing works
Quinn, T. J., Richard, E., Teuschl, Y., Gattringer, T., Hafdi, M., O'Brien, J. T., Merriman, N. A., Gillebert, C. R., Huygelier, H., Verdelho, A., et al. (2021) · European Stroke Journal · doi:10.1177/23969873211042192 · Cited by 141 · see citing works
Vascular Cognitive Impairment: Disease Mechanisms and Therapeutic Implications
Levine, D. A., & Langa, K. M. (2011) · Neurotherapeutics · doi:10.1007/s13311-011-0047-z · Cited by 130 · see citing works
Herrmann, N., Lanctôt, K. L., & Hogan, D. B. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt201 · Cited by 113 · see citing works
Cholinergic control of the cerebral vasculature in humans
Hamner, J. W., Tan, C. O., Tzeng, Y., & Taylor, J. A. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.245100 · Cited by 114 · see citing works
Vascular dementia: A microglia's perspective
Yang, Y. R., Zhao, X., Zhu, Z., & Zhang, L. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101734 · Cited by 103 · see citing works
Ihl, R., Frölich, L., Winblad, B. G., Schneider, L. S. S., Burns, A. S., Möller, H., & WFSBP Task Force on Treatment Guidelines for Alzheimer's Disease and other Dementias (2011) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2010.538083 · Cited by 97 · see citing works
Lin, Y., Wang, K., Ma, C., Wang, X., Gong, Z., Zhang, R., Zang, D., & Cheng, Y. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00227 · Cited by 87 · see citing works
Pharmacological Treatment of Vascular Dementia: A Molecular Mechanism Perspective
Kuang, H., Zhou, Z., Zhu, Y., Wan, Z., Yang, M.-W., Hong, F., & Yang, S. (2021) · Aging and Disease · doi:10.14336/ad.2020.0427 · Cited by 83 · see citing works
Wang, S., Yang, H., Zhang, J., Zhang, B., Liu, T., Gan, L., & Zheng, J. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1337-0 · Cited by 83 · see citing works
Kim, J. O., Lee, S. J., & Pyo, J. (2020) · PLoS ONE · doi:10.1371/journal.pone.0227820 · Cited by 83 · see citing works
Pharmacological prevention and treatment of vascular dementia: Approaches and perspectives
Baskys, A., & Cheng, J. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.07.002 · Cited by 71 · see citing works
Non-invasive brain stimulation to enhance cognitive rehabilitation after stroke
Draaisma, L. R., Wessel, M. J., & Hummel, F. C. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.06.047 · Cited by 68 · see citing works
Tan, C. O., & Taylor, J. A. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.072355 · Cited by 65 · see citing works
Contribution of Neuroimaging to the Diagnosis of Alzheimer’s Disease and Vascular Dementia
Román, G. C., & Pascual, B. (2012) · Archives of Medical Research · doi:10.1016/j.arcmed.2012.10.018 · Cited by 64 · see citing works
Alzheimer's disease with cerebrovascular disease: current status in the Asia–Pacific region
Chen, C., Homma, A., Mok, V., Krishnamoorthy, E. S., Alladi, S., Meguro, K., Abe, K., Dominguez, J. C., Marasigan, S., Kandiah, N., et al. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12495 · Cited by 64 · see citing works
Hippocampal Atrophy in Subcortical Vascular Dementia
van de Pol, L. A., Gertz, H., Scheltens, P., & Wolf, H. (2011) · Neurodegenerative Diseases · doi:10.1159/000326695 · Cited by 63 · see citing works
Acupuncture reversed hippocampal mitochondrial dysfunction in vascular dementia rats
Li, H., Liu, Y., Lin, L.-T., Wang, X., Du, S., Yan, C.-Q., He, T., Yang, J., & Liu, C. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.12.001 · Cited by 61 · see citing works
Therapeutic Strategies and Drug Development for Vascular Cognitive Impairment
Smith, E. E., Cieślak, A., Barber, P. A., Chen, J. Y., Chen, Y., Donnini, I., Edwards, J. D., Frayne, R., Field, T. S., Hegedus, J., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.005568 · Cited by 60 · see citing works
Self-citationVascular cognitive impairment: epidemiology, subtypes, diagnosis and management
Black, S. E. (2011) · The Journal of the Royal College of Physicians of Edinburgh · doi:10.4997/jrcpe.2011.121 · Cited by 56 · see citing works
Self-citationEfficacy of Cholinesterase Inhibitors in Vascular Dementia: An Updated Meta-Analysis
Chen, Y., Zhang, J., Wang, Y., Yuan, J., & Hu, W. (2016) · European Neurology · doi:10.1159/000444253 · Cited by 53 · see citing works
Clinical Practice Guideline for Stroke Rehabilitation in Korea 2016
Kim, D. Y., Kim, Y., Lee, J., Chang, W. H., Kim, M.-W., Pyun, S., Yoo, W., Ohn, S. H., Park, K. D., Oh, B., et al. (2017) · Brain & Neurorehabilitation · doi:10.12786/bn.2017.10.e11 · Cited by 52 · see citing works
Yang, J., Wang, X., Zhang, M., Xiao, L., Zhu, W. X., Ji, C., & Liu, C. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13063 · Cited by 48 · see citing works
Cortical Hubs and Subcortical Cholinergic Pathways as Neural Substrates of Poststroke Dementia
Lim, J., Kim, N., Jang, M. U., Han, M., Kim, S., Baek, M. J., Jang, M. S., Ban, B., Kang, Y., Kim, D., et al. (2014) · Stroke · doi:10.1161/strokeaha.113.004156 · Cited by 47 · see citing works
Self-citationHuperzine A for vascular dementia
Hao, Z., Liu, M., Liu, Z., & Lu, D. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007365.pub2 · Cited by 48 · see citing works
Cognitive Decline in Heart Failure: More Attention is Needed
Čelutkienė, J., Vaitkevičius, A., Jakštienė, S., & Jatužis, D. (2016) · Cardiac failure review · doi:10.15420/cfr.2016:19:2 · Cited by 46 · see citing works
Effectiveness of Florbetapir PET Imaging in Changing Patient Management
Pontecorvo, M., Siderowf, A., Dubois, B., Doraiswamy, P., Frisoni, G., Grundman, M., Nobili, F., Sadowsky, C., Salloway, S., Arora, A. K., et al. (2017) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000478007 · Cited by 44 · see citing works
Self-citationUse of Cholinesterase Inhibitors in Non-Alzheimer’s Dementias
Noufi, P. E., Khoury, R., Jeyakumar, S., & Grossberg, G. T. (2019) · Drugs & Aging · doi:10.1007/s40266-019-00685-6 · Cited by 44 · see citing works
Liu, H., & Jin, B. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.249228 · Cited by 44 · see citing works
Pharmacokinetic and pharmacodynamic evaluation of donepezil for the treatment of Alzheimer's disease
Prvulovic, D., & Schneider, B. (2014) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2014.915028 · Cited by 41 · see citing works
Ma, J., Zhang, J., Hou, W., Wu, X. H., Liao, R., Chen, Y., Wang, Z., Zhang, X. N., Zhang, L. S., Zhou, Y., et al. (2015) · Scientific Reports · doi:10.1038/srep12079 · Cited by 41 · see citing works
Abnormal Intrinsic Brain Activity Patterns in Patients with Subcortical Ischemic Vascular Dementia
Liu, C., Li, C., Yin, X., Yang, J., Zhou, D., Gui, L., & Wang, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087880 · Cited by 41 · see citing works
Neuroprotection in vascular dementia: A future path
Skoog, I. G., Korczyn, A. D., & Guekht, A. B. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.02.013 · Cited by 38 · see citing works
Matsumoto, K., Zhao, Q., Niu, Y., Fujiwara, H., Tanaka, K., Sasaki‐Hamada, S., & Oka, J. (2013) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13r03cr · Cited by 37 · see citing works
Grundman, M., Johnson, K. A., Lu, M., Siderowf, A. D., Dell’Agnello, G., Arora, A., Skovronsky, D., Mintun, M. A., Pontecorvo, M. J., & for the <sup>18</sup>F-AV-45-A17 Study Group (2016) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000441139 · Cited by 37 · see citing works
Is Helicobacter pylori infection a critical risk factor for vascular dementia?
Xu, Y., Wang, Q., Liu, Y., Cui, R., & Zhao, Y. (2015) · International Journal of Neuroscience · doi:10.3109/00207454.2015.1081387 · Cited by 36 · see citing works
The Impact of Cognitive Impairment on Cardiovascular Disease
Jamil, Y., Krishnaswami, A., Orkaby, A. R., Stimmel, M. B., Brown, C. H., Mecca, A. P., Forman, D. E., Rich, M. W., Nanna, M. G., & Damluji, A. A. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.04.057 · Cited by 39 · see citing works
Cost-effectiveness of cerebrospinal biomarkers for the diagnosis of Alzheimer’s disease
Lee, S. A. W., Sposato, L. A., Hachinski, V., & Cipriano, L. E. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0243-0 · Cited by 35 · see citing works
Clinical Practice Guideline for Stroke Rehabilitation in Korea
Kim, Y., Han, T. R., Jung, H. Y., Chun, M. H., Lee, J., Kim, D. Y., Paik, N., Park, S.-W., Kim, M.-W., Pyun, S., et al. (2009) · Brain & Neurorehabilitation · doi:10.12786/bn.2009.2.1.1 · Cited by 35 · see citing works
Cognitive Impairment in Patients with Stroke
D’Souza, C. E., Greenway, M. R. F., Graff‐Radford, J., & Meschia, J. F. (2021) · Seminars in Neurology · doi:10.1055/s-0040-1722217 · Cited by 32 · see citing works
Sheffrin, M., Miao, Y., Boscardin, W. J., & Steinman, M. A. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13511 · Cited by 30 · see citing works
Liu, C., Li, C., Yang, J., Gui, L., Zhao, L., Evans, A. C., Yin, X., & Wang, J. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.003 · Cited by 30 · see citing works
Neurotechnologies as tools for cognitive rehabilitation in stroke patients
Draaisma, L. R., Wessel, M. J., & Hummel, F. C. (2020) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2020.1820324 · Cited by 30 · see citing works
Tianzhi granule improves cognition and BPSD of vascular dementia: a randomized controlled trial
Shi, J., Wei, M., Ni, J., Sun, F., Sun, L., Wang, J., Yu, T., Wang, K., Lv, P., Wang, Y., et al. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02232-z · Cited by 28 · see citing works
Shi, X., Ren, G., Cui, Y., & Xu, Z. (2022) · Current Alzheimer Research · doi:10.2174/1567205019666220120112301 · Cited by 29 · see citing works
Treatment of Vascular Cognitive Impairment
Ritter, A. R., & Pillai, J. A. (2015) · Current Treatment Options in Neurology · doi:10.1007/s11940-015-0367-0 · Cited by 28 · see citing works
Cognitive Change in Donepezil Treated Patients with Vascular or Mixed Dementia
Rockwood, K. J., Mitnitski, A., Black, S. E., Richard, M., & Defoy, I. (2013) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100014670 · Cited by 27 · see citing works
Self-citationRosenberg, G. A. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0277-4 · Cited by 27 · see citing works
Current and Future Treatments of Vascular Cognitive Impairment
Ip, B. Y. M., Ko, H., Lam, B. Y. K., Au, L. W. C., Lau, A. Y. L., Huang, J., Kwok, A. J., Leng, X., Cai, Y., Leung, T. W. H., et al. (2024) · Stroke · doi:10.1161/strokeaha.123.044174 · Cited by 26 · see citing works
The pattern of brain gray matter impairments in patients with subcortical vascular dementia
Liu, C., Li, C., Gui, L., Zhao, L., Evans, A. C., Xie, B., Zhang, J., Wei, L., Zhou, D., Wang, J., et al. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.04.017 · Cited by 26 · see citing works
Yang, J., Wang, X., Ma, S., Yang, N., Li, Q., & Liu, C. (2019) · Acupuncture in Medicine · doi:10.1136/acupmed-2017-011491 · Cited by 26 · see citing works
Biomarkers identify the Binswanger type of vascular cognitive impairment
Erhardt, E. B., Pesko, J. C., Prestopnik, J., Thompson, J., Caprihan, A., & Rosenberg, G. A. (2018) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x18762655 · Cited by 25 · see citing works
Effects of Acupuncture on Glycometabolic Enzymes in Multi-infarct Dementia Rats
Zhao, L., Shen, P., Han, Y., Zhang, X., Nie, K., Cheng, H., Kan, B., Li, G., Yu, J., & Han, J. (2011) · Neurochemical Research · doi:10.1007/s11064-010-0378-x · Cited by 23 · see citing works
Vascular Cognitive Impairment and Post-Stroke Cognitive Deficits
Shim, H. (2013) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-013-0418-4 · Cited by 24 · see citing works
Dang, C., Wang, Q., Zhuang, Y., Li, Q., Feng, L., Xiong, Y., & Lu, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1451032 · Cited by 24 · see citing works
Ismail, Y. A., Haitham, Y., Walid, M., Mohamed, H., & El‐Satar, Y. M. A. (2025) · BMC Neurology · doi:10.1186/s12883-024-03933-4 · Cited by 20 · see citing works
Vascular Dementia and Crosstalk Between the Complement and Coagulation Systems
Parsi, M. M., Duval, C., & Ariëns, R. A. S. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.803169 · Cited by 21 · see citing works
Logue, M. W., Posner, H. B., Green, R. C., Moline, M. L., Cupples, L. A., Lunetta, K. L., Zou, H., Hurt, S. W., Farrer, L. A., DeCarli, C. S., et al. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.01.004 · Cited by 21 · see citing works
Self-citationKaźmierski, J., Messini, C. Z., Γκιόκα, Μ., & Tsolaki, M. (2018) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317518775044 · Cited by 19 · see citing works
Kebets, V., Gregoire, S. M., Charidimou, A., Barnes, J., Rantell, K. R., Brown, M. M., Jäger, H. R., Lisa Cipolotti, A., & Werring, D. J. (2015) · International Journal of Stroke · doi:10.1111/ijs.12544 · Cited by 20 · see citing works
Sheikh, M., & Ammar, M. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1398952 · Cited by 23 · see citing works
Vascular cognitive impairment: Biomarkers in diagnosis and molecular targets in therapy
Rosenberg, G. A. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15609542 · Cited by 18 · see citing works
Caramelli, P., Marinho, V., Laks, J., Coletta, M. V. D., Stella, F., Camargos, E. F., Smid, J., Barbosa, B. J. A. P., Schilling, L. P., Balthazar, M. L. F., et al. (2022) · Dementia & Neuropsychologia · doi:10.1590/1980-5764-dn-2022-s106pt · Cited by 17 · see citing works
Prescripciones inconvenientes en el tratamiento del paciente con deterioro cognitivo
Bayón, A. R., & Sampedro, F. G. (2012) · Neurología · doi:10.1016/j.nrl.2012.05.004 · Cited by 17 · see citing works
Ahuja, M., Siddhpuria, S., Karimi, A., Lewis, K., Wong, E. K. C., Lee, J., Reppas‐Rindlisbacher, C. E., Sood, E., Gabor, C., & Patterson, C. (2023) · Age and Ageing · doi:10.1093/ageing/afad205 · Cited by 15 · see citing works
Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease
Sivaraman, B., Raji, V., Velmurugan, B. A., & Natarajan, R. (2021) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527320666210928160159 · Cited by 15 · see citing works
Proarrhythmic major adverse cardiac events with donepezil: A systematic review with meta‐analysis
Nham, T., Garcia, M. C., Tsang, K. L. J., Silva, J. M., Schneider, T., Deng, J., Lohit, S., Mbuagbaw, L. C. E., & Holbrook, A. M. (2024) · Journal of the American Geriatrics Society · doi:10.1111/jgs.18909 · Cited by 15 · see citing works
O'Brien, J. T., & Thomas, A. J. (2017) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.15104 · Cited by 13 · see citing works
Current and Emerging Therapeutic Approaches for Vascular Cognitive Impairment and Dementia
Goodall, L., Lennon, M. J., Sachdev, P. S., Gorelick, P. B., Kovacic, J. C., & Samaras, K. (2026) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.09.1502 · Cited by 12 · see citing works
Man, J., Cui, K., Fu, X., Zhang, D., Lu, Z., Gao, Y., Yu, L., Li, N., & Wang, J. (2020) · Brain Research · doi:10.1016/j.brainres.2020.146782 · Cited by 12 · see citing works
Ravi, R., Das, S., Hakami, T. M., M., P. B., & Pushparajan, L. (2025) · Stroke Research and Treatment · doi:10.1155/srat/6893801 · Cited by 11 · see citing works
Effect of yokukansan on memory disturbance in an animal model of cerebrovascular dementia
Nogami, A., Takasaki, K., Kubota, K., Yamaguchi‐Shinozaki, K., Kawasaki, C., Nakamura, K., Fujikawa, R., Uchida, N., Katsurabayashi, S., Mishima, K., et al. (2013) · doi:10.11339/jtm.30.164 · Cited by 11 · see citing works
Vascular cognitive impairment in India: Challenges and opportunities for prevention and treatment
Arshad, F., Samim, M. M., Paplikar, A., Rajendran, S. P., Kalkonde, Y. V., & Alladi, S. (2021) · Cerebral Circulation - Cognition and Behavior · doi:10.1016/j.cccb.2021.100034 · Cited by 11 · see citing works
Takramah, W. K., & Asem, L. (2022) · Health Science Reports · doi:10.1002/hsr2.913 · Cited by 12 · see citing works
Turning the Spotlight to Cholinergic Pharmacotherapy of the Human Language System
Dávila, G., Torres‐Prioris, M. J., López-Barroso, D., & Berthier, M. L. (2023) · CNS Drugs · doi:10.1007/s40263-023-01017-4 · Cited by 10 · see citing works
Management of Cognitive Impairment After Stroke
Jerdi, S. A., Aleyadeh, R., & Imam, Y. Z. B. (2020) · Current Treatment Options in Neurology · doi:10.1007/s11940-020-00627-3 · Cited by 10 · see citing works
Inappropriate treatments for patients with cognitive decline
Bayón, A. R., & Sampedro, F. G. (2014) · Neurología (English Edition) · doi:10.1016/j.nrleng.2012.05.009 · Cited by 10 · see citing works
Butler, R., & Radhakrishnan, R. (2012) · PubMed Central · Cited by 10 · see citing works
Alzheimer's Disease and Vascular Dementia, Connecting and Differentiating Features
Hurła, M., Banaszek, N., Kozubski, W. P., & Dorszewska, J. (2024) · Current Alzheimer Research · doi:10.2174/0115672050319219240711103459 · Cited by 9 · see citing works
Donepezil in the treatment of Alzheimer's disease
Marucci, G., Moruzzi, M., & Amenta, F. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815854-8.00031-8 · Cited by 9 · see citing works
Imaging, Genetic, and Pathological Features of Vascular Dementia
Yang, X., Chen, C., Wang, A., Li, C., & Cheng, G. (2023) · European Neurology · doi:10.1159/000531088 · Cited by 10 · see citing works
Post-Stroke Cognitive Impairment
Patel, B. B., & Birns, J. (2015) · Springer eBooks · doi:10.1007/978-3-319-17855-4_12 · Cited by 9 · see citing works
Comparison of Medial Temporal Measures between Binswanger's Disease and Alzheimer's Disease
Yin, X., Liu, C., Gui, L., Zhao, L., Zhang, J., Wei, L., Xie, B., Zhou, D., Li, C., & Wang, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086423 · Cited by 9 · see citing works
Puerarin decreases hypoxia inducible factor-1 alpha in the hippocampus of vascular dementia rats.
Wu, H., Wang, H., Zhang, B., Zhang, G., Zhang, R., & Zhang, L. (2012) · Europe PMC (PubMed Central) · doi:10.3969/j.issn.1673-5374.2012.06.003 · Cited by 9 · see citing works
- Authors
- Román, G. C., Salloway, S., Black, S. E., Royall, D. R., DeCarli, C., Weiner, M. W., Moline, M., Kumar, D., Schindler, R., & Posner, H.
- Affiliations
- From the Department of Neurology (G.C.R.), School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Tex; Department of Neurology and the Memory and Aging Program (S.S.), Brown Alpert Medical School, Butler Hospital, Providence, RI; Department of Neurology (S.E.B.), University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Canada; Departments of Psychiatry, Medicine, Pharmacology, and Family and Community Medicine, Division of Aging and Geriatric Psychiatry ...
- San Francisco VA Medical Center (US)
- ORCID
- Venue
- Stroke
- Published
- 2010-06
- Volume
- 41
- Issue
- 6
- Pages
- 1213-1221
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- PMC
- PMC2954887
- OpenAlex
- W2155669855
- Cited by
- 161
- References
- 30
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 12 · 2023: 4 · 2022: 9 · 2021: 10 · 2020: 11 · 2019: 6 · 2018: 9 · 2017: 11 · 2016: 15 · 2015: 11 · 2014: 11 · 2013: 12 · 2012: 9
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Pfizer
- Eisai
- National Institute on Aging (P30AG010129)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- donepezil, vascular dementia, cholinesterase inhibitors, cognitive function, hippocampal atrophy, mortality, adverse events, treatment response
- MeSH terms
- Donepezil, Adult, Aged, Aged, 80 and over, Cognition, Double-Blind Method, Female, Hippocampus, Humans, Indans, Male, Middle Aged, Organ Size, Piperidines, Radiography, Dementia, Vascular, Nootropic Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
