The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Molecular Pathophysiology of Cerebral Hemorrhage: Secondary Brain Injury
Open accessAbstract
Intracerebral hemorrhage (ICH) is an often fatal type of stroke that kills ≈30 000 people annually in the United States. If the patient survives the ictus, then the resulting hematoma within brain parenchyma triggers a series of adverse events causing secondary insults and severe neurological deficits. This article discusses selected aspects of secondary brain injury after ICH and outlines key mechanisms associated with hematoma toxicity, oxidative stress, and inflammation. Finally, this review discusses the relevance of hematoma resolution processes as a target for ICH therapy and presents potential clinically relevant molecular targets that could be harnessed to treat secondary injury associated with ICH injury.
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Cites
Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway
Kensler, T. W., Wakabayashi, N., & Biswal, S. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.46.120604.141046 · Cited by 3,630
Identification of the receptor scavenging hemopexin-heme complexes
Hvidberg, V., Maniecki, M. B., Jacobsen, C., Højrup, P., Møller, H. J., & Moestrup, S. K. (2005) · Blood · doi:10.1182/blood-2005-03-1185 · Cited by 473
Cited by
Pathophysiology and treatment of stroke: present status and future perspectives
Kuriakose, D., & Xiao, Z. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207609 · Cited by 1,350
Intracerebral haemorrhage: mechanisms of injury and therapeutic targets
Keep, R. F., Hua, Y., & Xi, G. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70104-7 · Cited by 1,308
Neuroinflammation after Intracerebral Hemorrhage and Potential Therapeutic Targets
Tschoe, C., Bushnell, C. D., Duncan, P. W., Alexander-Miller, M. A., & Wolfe, S. Q. (2020) · Journal of Stroke · doi:10.5853/jos.2019.02236 · Cited by 490
Roles of Peroxisome Proliferator-Activated Receptor Gamma on Brain and Peripheral Inflammation
Villapol, S. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-017-0554-5 · Cited by 369
Microglia Phenotypes in Aging and Neurodegenerative Diseases
Wendimu, M. Y., & Hooks, S. B. (2022) · Cells · doi:10.3390/cells11132091 · Cited by 336
Metadata
- Authors
- Aronowski, J., & Zhao, X.
- Venue
- Stroke
- Published
- 2011-06
- Volume
- 42
- Issue
- 6
- Pages
- 1781-1786
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2142511211
- Cited by
- 832
- References
- 2
- FWCI
- 15.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Aronowski, J., & Zhao, X. (2011). Molecular Pathophysiology of Cerebral Hemorrhage: Secondary Brain Injury. Stroke. https://doi.org/10.1161/strokeaha.110.596718
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
