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Cited by 1,308Intracerebral and Subarachnoid Hemorrhage ResearchIntracranial Aneurysms: Treatment and ComplicationsTraumatic Brain Injury and Neurovascular Disturbances

Intracerebral haemorrhage: mechanisms of injury and therapeutic targets

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Keep, Richard F, Hua, Ya, Xi, Guohua·2012·The Lancet Neurology
DOI 10.1016/s1474-4422(12)70104-7PMC PMC3884550
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Abstract

Intracerebral haemorrhage accounts for about 10-15% of all strokes and is associated with high mortality and morbidity. No successful phase 3 clinical trials for this disorder have been completed. In the past 6 years, the number of preclinical and clinical studies focused on intracerebral haemorrhage has risen. Important advances have been made in animal models of this disorder and in our understanding of mechanisms underlying brain injury after haemorrhage. Several therapeutic targets have subsequently been identified that are now being pursued in clinical trials. Many clinical trials have been based on limited preclinical data, and guidelines to justify taking preclinical results to the clinic are needed.

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  • Hemorrhagic stroke transformation is sometimes a consequence of thrombolytic tPA therapy for ischemia, and dysfunctional blood-brain barrier is the primary initiator of the pathology.

    “Hemorrhagic stroke transformation is sometimes a consequence of thrombolytic tPA therapy for ischemia, and dysfunctional BBB is the primary initiator of the pathology (306, 312).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [306]

    The Primary injury section discusses tPA as an aid to evacuating an existing intracerebral haematoma, not as treatment for ischaemic stroke followed by haemorrhagic transformation. The Secondary injury section describes blood–brain barrier disruption after thrombin exposure, but does not identify it as the primary initiator of haemorrhagic transformation. Searches for thrombolytic tPA and haemorrhagic transformation found no passage addressing that claim. (LLM, conf=0.73)

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Cited by

Sorted by citations

Authors
Keep, R. F., Hua, Y., & Xi, G.
Affiliations
University of Michigan (US)
Corresponding author
Keep, Richard F
ORCID
Venue
The Lancet Neurology
Publisher
Elsevier BV
Published
2012-08
Volume
11
Issue
8
Pages
720-731
ISSN
1474-4422 (ISSN-L)
DOI
10.1016/s1474-4422(12)70104-7
PMC
PMC3884550
OpenAlex
W2123301364
Cited by
1,308
References
3
Citations by year
2026: 100 · 2025: 105 · 2024: 140 · 2023: 111 · 2022: 118 · 2021: 132 · 2020: 115 · 2019: 92 · 2018: 92 · 2017: 86 · 2016: 75 · 2015: 62 · 2014: 48 · 2013: 24 · 2012: 6
FWCI
6.29
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (NS 039866, NS-034709, NS-057539, R01NS039866, NS 073595, R01NS034709, R01NS073595, R01NS057539)
Topics
  • Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
  • Health Sciences › Medicine › Neurology › Intracranial Aneurysms: Treatment and Complications
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
intracerebral hemorrhage, therapeutic target, stroke, clinical trials, neuroprotection
MeSH terms
Cerebral Hemorrhage, Humans, Stroke

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