The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The Importance of Size: Successful Recanalization by Intravenous Thrombolysis in Acute Anterior Stroke Depends on Thrombus Length
Open accessAbstract
Background and Purpose—: We hypothesize that in acute middle cerebral artery stroke, thrombus lengths measured in thin-slice nonenhanced CT images define a limit beyond which systemic thrombolysis will fail to recanalize occluded arteries. Methods—: In 138 patients who presented with acute middle cerebral artery stroke and who were treated with intravenous thrombolysis (IVT), we measured lengths of thrombotic clots depicted as arterial hyperdensities in admission nonenhanced CT images with 2.5-mm slice width. Vascular recanalization was investigated after thrombolysis and recanalization results were related to thrombus lengths by logistic regression. Results—: In 62 patients, IVT resulted in recanalization; among these patients, no thrombus length exceeded 8 mm. The median modified Rankin scale score at hospital discharge was 2. In the remaining 76 patients, thrombus lengths mostly exceeded 8 mm and IVT failed in recanalization. These patients were discharged with a median modified Rankin scale score of 5. Conclusions—: This study shows that in acute middle cerebral artery stroke, IVT has nearly no potential to recanalize occluded vessels if thrombus length exceeds 8 mm.
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Cites
The Impact of Recanalization on Ischemic Stroke Outcome: A Meta-Analysis
Rha, J.-H., & Saver, J. L. (2007) · Stroke · doi:10.1161/01.str.0000258112.14918.24 · Cited by 1,452
Puetz, V., Dzialowski, I., Hill, M. D., Subramaniam, S., Sylaja, P. N., Krol, A., O'Reilly, C., Hudon, M. E., Hu, W. Y., Coutts, S. B., et al. (2008) · International Journal of Stroke · doi:10.1111/j.1747-4949.2008.00221.x · Cited by 304
Prevalence and significance of hyperdense middle cerebral artery in acute stroke.
Leys, D., Pruvo, J. P., Godefroy, O., Rondepierre, P., & Leclerc, X. (1992) · Stroke · doi:10.1161/01.str.23.3.317 · Cited by 260
CT visualization of intracranial arterial thromboembolism.
Gács, G., Fox, A. J., Barnett, H. J., & Vinuela, F. (1983) · Stroke · doi:10.1161/01.str.14.5.756 · Cited by 196
Riedel, C. H., Jensen, U. R., Rohr, A., Tietke, M., Alfke, K., Ulmer, S., & Jansen, O. (2010) · Stroke · doi:10.1161/strokeaha.110.580662 · Cited by 151
Self-citationKharitonova, T. V., Thoren, M., Ahmed, N., Wardlaw, J. M., von Kummer, R., Thomassen, L., Wahlgren, N. G., & for the SITS investigators (2008) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.150185 · Cited by 72
Hyperdense Internal Carotid Artery Sign
Özdemir, Ö., Leung, A., Bussière, M., Hachinski, V., & Pelz, D. M. (2008) · Stroke · doi:10.1161/strokeaha.107.505230 · Cited by 49
Cited by
Nogueira, R. G., Lutsep, H. L., Gupta, R., Jovin, T. G., Albers, G. W., Walker, G. A., Liebeskind, D. S., & Smith, W. S. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61299-9 · Cited by 1,110
Sacks, D., Baxter, B., Campbell, B. C. V., Carpenter, J. S., Cognard, C., Dippel, D., Eesa, M., Fischer, U., Hausegger, K., Hirsch, J. A., et al. (2018) · Journal of Vascular and Interventional Radiology · doi:10.1016/j.jvir.2017.11.026 · Cited by 686
Self-citationFrom the American Association of Neurological Surgeons (AANS), A. S. O. N. (., Sacks, D., Baxter, B., Campbell, B. C. V., Carpenter, J. S., Cognard, C., Dippel, D., Eesa, M., Fischer, U., Hausegger, K., et al. (2018) · American Journal of Neuroradiology · doi:10.3174/ajnr.a5638 · Cited by 599
Self-citationAcute Stroke Imaging Research Roadmap
Wintermark, M., Albers, G. W., Alexandrov, A. V., Alger, J. R., Bammer, R., Baron, J.-C., Davis, S., Demaerschalk, B. M., Derdeyn, C. P., Donnan, G. A., et al. (2008) · Stroke · doi:10.1161/strokeaha.107.512319 · Cited by 423
Machine learning for outcome prediction of acute ischemic stroke post intra-arterial therapy
Asadi, H., Dowling, R., Yan, B., & Mitchell, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088225 · Cited by 218
Metadata
- Authors
- Riedel, C. H., Zimmermann, P., Jensen-Kondering, U., Stingele, R., Deuschl, G., & Jansen, O.
- Venue
- Stroke
- Published
- 2011-06
- Volume
- 42
- Issue
- 6
- Pages
- 1775-1777
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2103780795
- Cited by
- 572
- References
- 7
- FWCI
- 33.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: The Importance of Size: Successful Recanalization by Intravenous Thrombolysis in Acute Anterior Stroke Depends on Thrombus Length. https://app.cochat.ai/papers/10.1161/strokeaha.110.609693
- The paper
- Riedel, C. H., Zimmermann, P., Jensen-Kondering, U., Stingele, R., Deuschl, G., & Jansen, O. (2011). The Importance of Size: Successful Recanalization by Intravenous Thrombolysis in Acute Anterior Stroke Depends on Thrombus Length. Stroke. https://doi.org/10.1161/strokeaha.110.609693
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