Increased Blood–Brain Barrier Permeability and Brain Edema After Focal Cerebral Ischemia Induced by Hyperlipidemia: Role of Lipid Peroxidation and Calpain-1/2, Matrix Metalloproteinase-2/9, and RhoA Overactivation

ElAli, Ayman, Doeppner, Thorsten R., Zechariah, Anil, Hermann, Dirk M.·2011·Stroke
DOI 10.1161/strokeaha.111.615559

Cited by (150)

Items 101–150 of 150

  1. Activation of Wnt3α/β-catenin signal pathway attenuates apoptosis of the cerebral microvascular endothelial cells induced by oxygen-glucose deprivation
    Jianshui Zhang, Junfeng Zhang, Cunfang Qi, Pengbo Yang, Xinlin Chen, Yong Liu · 2017 · Biochemical and Biophysical Research Communications
  2. Maternal high-fat diet programs cerebrovascular remodeling in adult rat offspring
    Chengcheng Lin, Xiaoyun Wu, YuLei Zhou, Bei Shao, Xiaoting Niu, Wanli Zhang, Yuanshao Lin · 2017 · Journal of Cerebral Blood Flow & Metabolism
  3. Modeling Vascular Risk Factors for the Development of Ischemic Stroke Therapies
    Dirk Matthias Hermann, Christoph Kleinschnitz · 2019 · Stroke
  4. Opportunities and Limitations of Vascular Risk Factor Models in Studying Plasticity-Promoting and Restorative Ischemic Stroke Therapies
    Dirk Matthias Hermann, Thorsten Roland Doeppner, Aurel Popa-Wagner · 2019 · Neural Plasticity
  5. Neuroprotective potential for mitigating ischemia-reperfusion-induced damage
    Zi Ye, Runqing Liu, Hangxing Wang, Aizhen Zuo, Cen Jin, Nan Wang, Huiqi Sun, Luqian Feng, Hua Yang · 2024 · Neural Regeneration Research
  6. Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages
    Dongpei Yin, Chen Wang, Yachao Qi, Yachao Wang, Nina Hagemann, Ayan Mohamud Yusuf, Egor Dzyubenko, Britta Kaltwasser, Tobias Tertel, Bernd Giebel et al. · 2023 · Journal of Neuroinflammation
  7. A 2-Min Transient Ischemia Confers Cerebral Ischemic Tolerance in Non-Obese Gerbils, but Results in Neuronal Death in Obese Gerbils by Increasing Abnormal mTOR Activation-Mediated Oxidative Stress and Neuroinflammation
    J. Park, J. Ahn, Min-Ah Song, Hyunjung Kim, C. Park, Young Eun Park, Tae-Kyeong Lee, Jae-Chul Lee, Dae Won Kim, Choong-Hyun Lee et al. · 2019 · Cells
  8. Bone-derived PDGF-BB enhances hippocampal non-specific transcytosis through microglia-endothelial crosstalk in HFD-induced metabolic syndrome
    Guanqiao Liu, Wen Shu, Yingqi Chen, Yong Fu, Shuai Fang, Haonan Zheng, Weike Cheng, Qing‐rong Lin, Yanjun Hu, Nan Jiang et al. · 2024 · Journal of Neuroinflammation
  9. VEGF‐E Attenuates Injury After Ischemic Stroke by Promoting Reparative Revascularization
    Romain Menet, Leila Nasrallah, Maxime Bernard, Anne‐Sophie Allain, Ayman ElAli · 2025 · European Journal of Neuroscience
  10. Association of cholesterol levels with hemorrhagic transformation and cerebral edema after reperfusion therapies
    Irene Escudero‐Martínez, Magnus Thorén, Marius Matusevicius, Charith Cooray, Andrea Zini, Christine Roffe, Danilo Toni, Georgios K. Tsivgoulis, Peter Arthur Ringleb, Nils Gunnar Wahlgren et al. · 2022 · European Stroke Journal
  11. Beta-caryophyllene inhibits the permeability of the blood–brain barrier in MPTP-induced parkinsonism
    Ana Raquel Ramos-Molina, Aldo Rafael Tejeda-Martínez, Juan Manuel Viveros Paredes, Verónica Chaparro-Huerta, María Fernanda Urmeneta-Ortíz, Luis Javier Ramírez-Jirano, Mario Eduardo Flores-Soto · 2023 · Neurología
  12. Transcatheter treatment of atherosclerotic lesions of the brain complicated by vascular dementia development
    Ivan V. Maksimovich · 2012 · World Journal of Neuroscience
  13. Occludin and connexin 43 expression contribute to the pathogenesis of traumatic brain edema.
    Wanyin Ren, Guojie Jing, Qin Shen, Xiaoteng Yao, Yingchao Jing, Feng Lin, Weidong Pan · 2013 · PubMed Central
  14. Seinpin knockout exacerbates cerebral ischemia/reperfusion damage in mice
    Yong Chen, Lili Wei, Jing Tian, Yuhui Wang, Chaojie Liu, Chun Wang · 2016 · Biochemical and Biophysical Research Communications
  15. Effects of Serum Cholesterol on Severity of Stroke and Dosage of Statins on Functional Outcome in Acute Ischemic Stroke
    Priyanka Shridharan, Radhika Nair, Sankar Prasad Gorthi, Koteshwara Prakashini, Aparajita Chatterjee · 2023 · Neurology India
  16. Transcatheter Cerebral Revascularization in the Treatment of Atherosclerotic Lesions of the Brain
    Ivan V. Maksimovich · 2016 · Brain Disorders & Therapy
  17. Blood–Brain Barrier Permeability Dynamics and Mediation of Triglyceride–Glucose Index on Acute Ischemic Stroke Outcomes
    Fuqian Wang, Chenxi Zhao, Lianfang Shen, Huiying Wang, Yu Guo, Yue Cheng, Shuang Xia · 2025 · Journal of the American Heart Association
  18. Long-Term Alternating Fasting Increases Interleukin-13 in the Gerbil Hippocampus, But Does Not Protect BBB and Pyramidal Neurons From Ischemia–Reperfusion Injury
    Tae-Kyeong Lee, Yoonsoo Park, Bora Kim, Jae‐Chul Lee, Myoung Cheol Shin, Taek Geun Ohk, Chan Woo Park, Jun Hwi Cho, Joon Ha Park, Choong Hyun Lee et al. · 2020 · Neurochemical Research
  19. Astragaloside IV Improves Pulmonary Vascular Endothelial Dysfunction in Pulmonary Arterial Hypertension by Inhibiting Ferroptosis through Modulation of the Calpain-1/TGF-β/TFRC Pathway
    Lin-Chao Niu, Ru Zhang, Qi Qi, Bai-Lin Tang, Shengxue Yu, Guan Wang, Jingliang Zhang, Hongxin Wang · 2025 · The American Journal of Chinese Medicine
  20. Occludin and collagen IV degradation mediated by the T9SS effector SspA contributes to blood–brain barrier damage in ducks during Riemerella anatipestifer infection
    Zongchao Chen, Min Zhu, Dan Liu, Meng‐Si Wu, Pengfei Niu, Yang Yu, Chan Ding, Shengqing Yu · 2024 · Veterinary Research
  21. Lipid metabolism, microglia, and stroke
    Lei Chen, Minmin Zhang, Wei Wei, Qiang Li, Lijun Wang, Ming Zhao, Li He, Hongye Xu, Pengfei Yang, Ping Zhang · 2025 · Neural Regeneration Research
  22. Possibilities of transcatheter treatment of patients after extensive ischemic stroke
    Ivan V. Maksimovich · 2013 · World Journal of Neuroscience
  23. Decoding the Nexus: Cellular and Molecular Mechanisms Linking Stroke and Neurotoxic Microenvironments in Brain Cancer Patients
    Spiro Menounos, Helen M. Shen, Shraddha Tipirneni, Sonu M. M. Bhaskar · 2024 · Biomolecules
  24. Severe hypertriglyceridemia does not protect from ischemic brain injury in gene-modified hypertriglyceridemic mice
    Yong Chen, Ping Liu, Rong Qi, Yuhui Wang, Chaojie Liu, Chun Wang · 2016 · Brain Research
  25. Relationship between postinterventional cerebral hyperdensities and malignant brain edema in patients with acute ischemic stroke after mechanical thrombectomy
    Xiaocui Wang, Junhao Du, Yage Zhao, Zhiliang Guo, Jie Hou, Huaishun Wang, Guangyi Zhou, Guodong Xiao · 2025 · Frontiers in Neurology
  26. TRPM2 overactivation drives hyperlipidemia-induced dysfunction of myeloid cells and neurovascular units
    Pengyu Zong, Cindy Li, Jianlin Feng, Zhichao Yue, Nicholas Legere, Albert S. Yu, Fahad Shah, Adrianna Perez, Zhu Li, Evan R. Jellison et al. · 2025 · Cell Reports Medicine
  27. Neuroprotective and neurorestorative actions of mesenchymal stromal cell-derived small extracellular vesicles in the ischemic brain
    Chen Wang, Bernd Giebel, Dirk Matthias Hermann · 2022 · Exploration of neuroscience
  28. Decreased Interleukin 6 and Tumor Necrosis Factor α Proteins and Metalloproteinase-2,9 Levels Following Cerebral Ischemia in Cinnamon-treated Rats
    Mohammad Reza Mostajabi, Maryam Tavabi, Massoud Hatami, Mahin Ghanjkhani, Seyyed Saeid Mousavi, Mojtaba Fathi, Mehdi Eskandari, Hossein Mostafavi, Meysam Forouzandeh, Elham Ghasemloo · 2022 · Avicenna Journal of Pharmaceutical Research
  29. Cerebrovascular Imaging in a Rodent Stroke Model
    Saroj Kumar Amar, Uttpal Anand, Ankit Verma · 2021 · Springer eBooks
  30. Thrombus Metabolism‐Based Molecular Subtyping for Prognostic Risk Stratification in Acute Ischemic Stroke: A Preliminary Study
    Taoyuan Lu, Wei Li, Wenbo Cao, Yiying Liu, Jinzi Wei, Dechao Wang, Liqun Jiao, Xin Juan Xu · 2026 · CNS Neuroscience & Therapeutics
  31. Transcatheter Technologies in Treating Brain Atherosclerosis Complicated by Chronic Cerebrovascular Insufficiency
    Ivan V. Maksimovich · 2014 · Neuroscience &amp Medicine
  32. RETRACTED ARTICLE: Combination therapy for cerebral ischemia: do progesterone and noscapine provide better neuroprotection than either alone in the treatment?
    Manisha Kawadkar, Avinash Singh Mandloi, Nidhi Singh, Rajesh Mukharjee, Vipin V. Dhote · 2022 · Naunyn-Schmiedeberg s Archives of Pharmacology · Retracted
  33. Beta-caryophyllene inhibits the permeability of the blood–brain barrier in MPTP-induced parkinsonism
    Ana Raquel Ramos-Molina, Aldo Rafael Tejeda-Martínez, Juan Manuel Viveros Paredes, Verónica Chaparro-Huerta, María Fernanda Urmeneta-Ortíz, Luis Javier Ramírez-Jirano, Mario Eduardo Flores-Soto · 2025 · Neurología (English Edition)
  34. New approach to identify ischemic stroke patients at risk to develop hemorrhagic transformation.
    Bogdan Nicolae Manolescu, Glen C. Jickling · 2012 · Europe PMC (PubMed Central)
  35. PDGF-D is de novo expressed after stroke and contributes to neurovascular protection by rescuing the function of pericytes
    Maxime Bernard, Romain Menet, Sarah Lecordier, Ayman ElAli · 2023 · Research Square
  36. VEGF-induced angiogenesis in the ischemic brain
    Anil Zechariah · 2012 · DuEPublico (University of Duisburg-Essen)
  37. VEGF-induced angiogenesis in the ischemic brain: effect of hyperlipidemia
    Anil Zechariah · 2012 · DuEPublico (University of Duisburg-Essen)
  38. Comorbidities Often Associated with Brain Damage in Hypertension: Dyslipidaemia
    Dragan B. Lović, Manolis S. Kallistratos, Athanasios John Manolis · 2016 · Updates in hypertension and cardiovascular protection
  39. Relationship between Gastric Blood Perfusion and Gastric Mucosal Injury Induced by Acute Cerebrovascular Disease in Rats
    H. WANG, De-Wei Yu · 2021 · Indian Journal of Pharmaceutical Sciences
  40. Early complications of decompressive craniectomy in patients with severe traumatic brain injury
    T. G. Kairov, Aleksandr Ernestovich Talypov, Andrey Anatolievich Grin · 2024 · Russian journal of neurosurgery
  41. Comorbidities Often Associated with Brain Damage in Hypertension: Dyslipidaemia
    Athanasios John Manolis, Nikolaos Papaioannou, Manolis S. Kallistratos, Dragan B. Lović · 2024 · Updates in hypertension and cardiovascular protection
  42. Contrast enhancement after mechanical thrombectomy: clinical correlations and impact on outcomes
    Farid Khasiyev, Wilson Rodriguez, Gunjanpreet Kaur, Irshad Allahverdiyev, Brian Behdad Miremadi, Kara M Christopher, Guillermo Linares · 2024 · Acta Neurologica Belgica
  43. Additional file 1 of Bone-derived PDGF-BB enhances hippocampal non-specific transcytosis through microglia-endothelial crosstalk in HFD-induced metabolic syndrome
    Liu, Guanqiao, Shu, Wen, Chen, Yingqi, Fu, Yong, Fang, Shuai, Haonan Zheng, Weike Cheng, Lin, Qingrong, Hu, Yanjun, Jiang, Nan et al. · 2024 · Figshare
  44. Additional file 1 of Targeted thrombolysis by magnetoacoustic particles in photothrombotic stroke model
    Choi, Wonseok, Hyeyoun Cho, Kim, Gahee, Youn, Inchan, Key, Jaehong, Han, Sungmin · 2022 · Figshare
  45. Additional file 1 of Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages
    Dongpei Yin, Wang, Chen, Qi, Yachao, Wang, Ya-Chao, Nina Hagemann, Ayan Mohamud Yusuf, Egor Dzyubenko, Britta Kaltwasser, Tobias Tertel, Giebel, Bernd et al. · 2023 · Figshare
  46. The Change in Dementia Presentation During the Past Decades
    Kai-Ming Jhang, Chia-Je Lee, Yen-Chung Chen · 2026 · Springer eBooks
  47. Lipid dysregulation is associated with anxiety symptoms and left frontopolar cortical network alterations in overt hypothyroidism
    Jiancang Cao, Quan Zou, Xingqi Liu, X Wang, Wenxiu Ma, Na Luo, Xiangru Yan, Gang Huang, Lianping Zhao · 2026 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
  48. Neuroprotective properties of rice bran extract against heavy metal mixture-induced cerebellar toxicity via regulation of Nrf-2/HMOX-1/BDNF pathways in rats
    Baridoo Donatus Dooka, Chinna N. Orish, Anthonet Ndidiamaka Ezejiofor, Theresa Ugwu, Kpobari W. Nkpaa, Ifeoma Okereke, Ana Ćirović, Aleksandar Ćirović, Orish Ebere Orisakwe · 2026 · Journal of Trace Elements in Medicine and Biology
  49. Hyperlipidemia abolishes, but immune balancing by DNase-I restores neuroprotection by MSC-derived extracellular vesicles
    Chen Wang, Tobias Tertel, Yiqiao Zhang, Yanis Mouloud, Xiaolong Liu, Nina Hagemann, Ayan Mohamud Yusuf, Aurel Popa‐Wagner, Matthias Gunzer, Bernd Giebel et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  50. Pan-cancer oncolytic virotherapy through disruption of tumor cell mitochondrial dynamics
    Shufeng Feng, Lu Cui, Yongxin Zhu, Yao Cheng, Dongmei Diao, Xuefeng Li, Huimin Duan, Haixia Zhang, Xiaoxiao Liu, Qing Pan et al. · 2026 · Molecular Therapy