Increased Blood–Brain Barrier Permeability and Brain Edema After Focal Cerebral Ischemia Induced by Hyperlipidemia: Role of Lipid Peroxidation and Calpain-1/2, Matrix Metalloproteinase-2/9, and RhoA Overactivation
Abstract
Background and Purpose—: Hyperlipidemia is a highly prevalent risk factor for ischemic stroke. Its impact on brain injury and blood–brain barrier permeability, so far, has not been assessed in animal models of ischemic stroke. Methods—: Wild-type and apolipoprotein E −/− mice, fed with normal or cholesterol-rich high-fat food, were subjected to 30 minutes of middle cerebral artery occlusion. Ischemic injury, brain edema, IgG extravasation, lipid peroxidation, calpain-1/2, matrix metalloproteinase-2/9, and RhoA activation, and occludin expression were evaluated 24 hours after reperfusion. Results—: Cholesterol-rich food, but not apolipoprotein E deficiency, increased IgG extravasation and brain edema without influencing infarct area and the density of DNA fragmented cells. Increased lipid peroxidation and low-density lipoprotein oxidation were noticed in the brain of hyperlipidemic mice and were associated with increased activation of calpain-1/2 and matrix metalloproteinase-2/9, overactivation of RhoA and its guanine exchange factor leukemia-associated guanine exchange factor , and downregulation of the tight junction protein occludin in cerebral microvessels. Conclusions—: That postischemic blood–brain barrier permeability and brain edema are increased during hyperlipidemia points toward the importance of the recognition and adequate treatment of this highly prevalent condition. Translational studies should more adequately mimic risk factors prevalent in human stroke.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
These vascular changes are driven by factors including reduced eNOS activity, excessive lipid peroxidation, and overactivation of MMP2 and 9, calpain 1 and 2, and RhoA.
“These vascular changes are driven by many factors, including reduced endothelial NO synthase (eNOS) activity, excessive lipid peroxidation, and overactivation of matrix metalloproteinases 2 and 9, calpain 1 and 2, and the small RhoGTPase RhoA.83,84”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [84]
Hypercholesterolaemia reduces angiogenesis and promotes blood-brain barrier permeability.
“Hypercholesterolaemia reduces angiogenesis83 and promotes blood–brain barrier permeability.84”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [84]
Cites
High-Dose Atorvastatin after Stroke or Transient Ischemic Attack
The Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) Investigators (2006) · New England Journal of Medicine · doi:10.1056/nejmoa061894 · Cited by 2,887 · see citing works
1,026 Experimental treatments in acute stroke
O’Collins, V. E., Macleod, M. R., Donnan, G. A., Horky, L. L., van der Worp, H. B., & Howells, D. W. (2006) · Annals of Neurology · doi:10.1002/ana.20741 · Cited by 1,453 · see citing works
Roundtable, S. T. A. I. (1999) · Stroke · doi:10.1161/01.str.30.12.2752 · Cited by 1,258 · see citing works
Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke
Sacco, R. L., Diener, H.-C., Yusuf, S., Cotton, D., Ôunpuu, S., Lawton, W. A., Palesch, Y., Martin, R. H., Albers, G. W., Bath, P., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0805002 · Cited by 961 · see citing works
Superoxide and peroxynitrite inatherosclerosis.
White, C. R., Brock, T. A., Chang, L. Y., Crapo, J. D., BRISCOE, P. M., Ku, D. D., Bradley, W. A., Gianturco, S. H., Gore, J. Z., & Freeman, B. Α. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.3.1044 · Cited by 685 · see citing works
McNeish, J. D., Aiello, R. J., Guyot, D. J., Turi, T., Gabel, C. A., Aldinger, C. E., Hoppe, K. L., Roach, M. L., Royer, L. J., de Wet, J., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4245 · Cited by 539 · see citing works
Barton, M., Haudenschild, C. C., d’Uscio, L. V., Shaw, S., Münter, K., & Lüscher, T. F. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14367 · Cited by 356 · see citing works
Schreibelt, G., Kooij, G., Reijerkerk, A., van Doorn, R., Gringhuis, S. I., van der Pol, S., Weksler, B. B., Romero, I. A., Couraud, P., Piontek, J., et al. (2007) · The FASEB Journal · doi:10.1096/fj.07-8329com · Cited by 347 · see citing works
Kamada, H., Yu, F., Nito, C., & Chan, P. H. (2007) · Stroke · doi:10.1161/01.str.0000258041.75739.cb · Cited by 315 · see citing works
Hirase, T., Kawashima, S., Wong, E. Y. M., Ueyama, T., Rikitake, Y., Tsukita, S., Yokoyama, M., & Staddon, J. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007136200 · Cited by 312 · see citing works
Leppälä, J. M., Virtamo, J., Fogelholm, R., Albanes, D., & Heinonen, O. P. (1999) · Stroke · doi:10.1161/01.str.30.12.2535 · Cited by 272 · see citing works
Role of RhoA and Rho Kinase in Lysophosphatidic Acid–Induced Endothelial Barrier Dysfunction
Amerongen, G. P. V. N., Vermeer, M. A., & van Hinsbergh, V. W. M. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.12.e127 · Cited by 174 · see citing works
Reitmeir, R., Kilic, E., Kilic, Ü., Bacigaluppi, M., ElAli, A., Salani, G., Pluchino, S., Gassmann, M., & Hermann, D. M. (2011) · Brain · doi:10.1093/brain/awq344 · Cited by 156 · see citing works
Self-citationApoE Deficiency Compromises the Blood Brain Barrier Especially After Injury
Methia, N., André, P., Hafezi-Moghadam, A., Economopoulos, M., Thomas, K. L., & Wagner, D. D. (2001) · Molecular Medicine · doi:10.1007/bf03401973 · Cited by 150 · see citing works
ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage
Hafezi-Moghadam, A., Thomas, K. L., & Wagner, D. D. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00563.2005 · Cited by 149 · see citing works
Sugimoto, K., Ishibashi, T., Sawamura, T., Inoue, N., Kamioka, M., Uekita, H., Ohkawara, H., Sakamoto, T., Sakamoto, N., Okamoto, Y., et al. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp177 · Cited by 124 · see citing works
Cerebral Vascular Dysfunction During Hypercholesterolemia
Kitayama, J., Faraci, F. M., Lentz, S. R., & Heistad, D. D. (2007) · Stroke · doi:10.1161/strokeaha.107.481879 · Cited by 102 · see citing works
A novel role for calpains in the endothelial dysfunction of hyperglycemia
Stalker, T. J., Skvarka, C. B., & Scalia, R. G. (2003) · The FASEB Journal · doi:10.1096/fj.02-1213fje · Cited by 85 · see citing works
Zechariah, A., ElAli, A., & Hermann, D. M. (2010) · Stroke · doi:10.1161/strokeaha.109.574418 · Cited by 84 · see citing works
Self-citationRole of Nogo-A in neuronal survival in the reperfused ischemic brain
Kilic, E., ElAli, A., Kilic, Ü., Guo, Z., Ugur, M., Uslu, U., Bassetti, C. L., Schwab, M. E., & Hermann, D. M. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.268 · Cited by 79 · see citing works
Self-citationRisk Factor Profile and Management of Cerebrovascular Patients in the REACH Registry
Röther, J., Alberts, M. J., Touzé, E., Mas, J., Hill, M. D., Michel, P., Bhatt, D. L., Aichner, F., Goto, S., Matsumoto, M., et al. (2008) · Cerebrovascular Diseases · doi:10.1159/000120687 · Cited by 69 · see citing works
Chaitanya, G. V., & Babu, P. P. (2008) · Neurochemical Research · doi:10.1007/s11064-007-9567-7 · Cited by 62 · see citing works
Apolipoprotein E Controls ATP-Binding Cassette Transporters in the Ischemic Brain
ElAli, A., & Hermann, D. M. (2010) · Science Signaling · doi:10.1126/scisignal.2001213 · Cited by 49 · see citing works
Self-citationMatter, C. M., Ma, L., von Lukowicz, T., Meier, P., Lohmann, C., Zhang, D., Kılıç, Ü., Hofmann, E., Ha, S., Hersberger, M., et al. (2006) · Stroke · doi:10.1161/01.str.0000241068.50156.82 · Cited by 34 · see citing works
Self-citationJansen, P. J., Lütjohann, D., Thelen, K., von Bergmann, K., LEUVEN, F. V., Ramaekers, F. C. S., & Monique, M. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-1150 · Cited by 34 · see citing works
Pan, S., White, T. A., Witt, T. A., Chiriac, A. E., Mueske, C. S., & Simari, R. D. (2009) · Circulation Research · doi:10.1161/circresaha.109.195016 · Cited by 27 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Blood-brain barrier dysfunction and recovery after ischemic stroke
Jiang, X., Andjelkovic, A. V., Zhu, L., Yang, T., Bennett, M. V. L., Chen, J., Keep, R. F., & Shi, Y. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.10.001 · Cited by 946 · see citing works
Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke
Hu, X., Silva, T. M. D., Chen, J., & Faraci, F. M. (2017) · Circulation Research · doi:10.1161/circresaha.116.308427 · Cited by 444 · see citing works
Liu, J., Jin, X., Liu, K. J., & Liu, W. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6409-11.2012 · Cited by 434 · see citing works
Hermann, D. M., & Chopp, M. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70039-x · Cited by 333 · see citing works
Self-citationHerz, J., Sabellek, P., Lane, T. E., Gunzer, M., Hermann, D. M., & Doeppner, T. R. (2015) · Stroke · doi:10.1161/strokeaha.115.010620 · Cited by 216 · see citing works
Self-citationPrzykaza, Ł. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.782569 · Cited by 177 · see citing works
Oppenheim, H., Lucero, J., Guyot, A.-C., Herbert, L. M., McDonald, J. D., Mabondzo, A. M., & Lund, A. K. (2013) · Particle and Fibre Toxicology · doi:10.1186/1743-8977-10-62 · Cited by 173 · see citing works
Enciu, A., Gherghiceanu, M., & Popescu, B. O. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/297512 · Cited by 150 · see citing works
Wang, W., Li, M., Chen, Q., & Wang, J. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8952-x · Cited by 149 · see citing works
High fat diet exacerbates Alzheimer's disease-related pathology in APPswe/PS1 mice
Thériault, P., ElAli, A., & Rivest, S. (2016) · Oncotarget · doi:10.18632/oncotarget.12179 · Cited by 119 · see citing works
Self-citationHydrogen sulfide protects blood–brain barrier integrity following cerebral ischemia
Wang, Y., Jia, J., Ao, G., Hu, L., Liu, H., Xiao, Y., Du, H., Alkayed, N. J., Liu, C., & Cheng, J. G. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12695 · Cited by 118 · see citing works
Salas-Venegas, V., Flores-Torres, R. P., Rodríguez-Cortés, Y. M., Rodríguez-Retana, D., Carreto, R. J. R., Concepción-Carrillo, L. E., Pérez-Flores, L. J., Alarcón‐Aguilar, A., López‐Díazguerrero, N. E., Gómez‐González, B., et al. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.798995 · Cited by 118 · see citing works
Mitochondrial dysfunction – Silent killer in cerebral ischemia
Pramila, B., & Shanmugam, P. S. T. (2017) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2017.02.043 · Cited by 112 · see citing works
Zechariah, A., ElAli, A., Hagemann, N., Jin, F., Doeppner, T. R., Helfrich, I., Mies, G., & Hermann, D. M. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300749 · Cited by 103 · see citing works
Self-citationDistinct Patterns of Cerebral Extravasation by Evans Blue and Sodium Fluorescein in Rats
Yen, L. F., Wei, V. C., Kuo, E. Y., & Lai, T. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068595 · Cited by 101 · see citing works
Candelario‐Jalil, E., & Paul, S. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113494 · Cited by 89 · see citing works
The role of the immune system in central nervous system plasticity after acute injury
Peruzzotti‐Jametti, L., Donegà, M., Giusto, E., Mallucci, G., Marchetti, B., & Pluchino, S. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.04.036 · Cited by 84 · see citing works
Ye, F., Kaneko, H., Hayashi, Y., Takayama, K., Hwang, S.-J., Nishizawa, Y., Kimoto, R., Nagasaka, Y., Tsunekawa, T., Matsuura, T., et al. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.027 · Cited by 78 · see citing works
Hyperlipidemia in Stroke Pathobiology and Therapy: Insights and Perspectives
Menet, R., Bernard, M., & ElAli, A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00488 · Cited by 74 · see citing works
Self-citationNeurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors
Lecordier, S., Manrique‐Castano, D., Moghrabi, Y. E., & ElAli, A. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.727590 · Cited by 76 · see citing works
Self-citationAnimal models of ischemic stroke and their impact on drug discovery
Hermann, D. M., Popa‐Wagner, A., Kleinschnitz, C., & Doeppner, T. R. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1573984 · Cited by 70 · see citing works
Self-citationLeBlanc, N. J., Menet, R., Picard, K., Parent, G., Tremblay, M., & ElAli, A. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1539-9 · Cited by 67 · see citing works
Self-citationDeng, J., Zhang, J., Feng, C., Xiong, L., & Zuo, Z. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu154 · Cited by 67 · see citing works
Huang, L., Song, J., Cai, H., Wang, P., Yin, Q.-L., Zhang, Y., Chen, J., Li, M., Song, J., Wang, Y., et al. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.841544 · Cited by 61 · see citing works
Jiang, Y., He, R., Shi, Y., Liang, J., & Zhao, L. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117987 · Cited by 60 · see citing works
Geng, Y., Li, E., Mu, Q., Zhang, Y., Wei, X., Li, H., Cheng, L., & Zhang, B. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.223 · Cited by 59 · see citing works
Aging-Related Changes in Blood-Brain Barrier Integrity and the Effect of Dietary Fat
Takechi, R., Pallebage‐Gamarallage, M. M., Lam, V., Giles, C., & Mamo, J. C. L. (2012) · Neurodegenerative Diseases · doi:10.1159/000343211 · Cited by 59 · see citing works
Emerging role of microRNAs in ischemic stroke with comorbidities
Yu, Q., Chopp, M., & Chen, J. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113382 · Cited by 58 · see citing works
Attenuated Blood-Brain Barrier Dysfunction by XQ-1H Following Ischemic Stroke in Hyperlipidemic Rats
Fang, W., Sha, L., Kodithuwakku, N. D., Wei, J., Rui, Z., Han, D., Mao, L., & Li, Y. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8851-1 · Cited by 55 · see citing works
Yu, S., Kim, S. R., Jiang, K., Ogrodnik, M. B., Zhu, X. Y., Ferguson, C. M., Tchkonia, T., Lerman, A., Kirkland, J. L., & Lerman, L. O. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/8875729 · Cited by 53 · see citing works
Nejad, S. H., Takechi, R., Mullins, B. J., Giles, C., Larcombe, A. N., Bertolatti, D., Rumchev, K. B., Dhaliwal, S. S., & Mamo, J. C. L. (2014) · Journal of Applied Toxicology · doi:10.1002/jat.2985 · Cited by 51 · see citing works
Herz, J., Hagen, S. I., Bergmüller, E., Sabellek, P., Göthert, J. R., Buer, J., Hansen, W., Hermann, D. M., & Doeppner, T. R. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.10.022 · Cited by 50 · see citing works
Self-citationNuzzo, D., Galizzi, G., Amato, A., Terzo, S., Picone, P., Cristaldi, L., Mulè, F., & Carlo, M. D. (2020) · Antioxidants · doi:10.3390/antiox9040317 · Cited by 50 · see citing works
Jin, X., Liu, J., Liu, K. J., Rosenberg, G. A., Yang, Y. R., & Liu, W. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.11.018 · Cited by 49 · see citing works
Attenuation of Blood-Brain Barrier Breakdown and Hyperpermeability by Calpain Inhibition
Alluri, H., Grimsley, M., Shaji, C. A., Varghese, K. P., Zhang, S. L., Peddaboina, C. S., Robinson, B. D., Beeram, M., Huang, J. H., & Tharakan, B. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.735365 · Cited by 49 · see citing works
Targeting PCSK9 for therapeutic gains: Have we addressed all the concerns?
Banerjee, Y., Santos, R. D., Al‐Rasadi, K., & Rizzo, M. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.02.018 · Cited by 48 · see citing works
Choi, K.-S., Choi, H.-J., Lee, J.-K., Im, S., Zhang, H., Jeong, Y., Park, J. A., Lee, I., Kim, Y., & Kwon, Y. (2016) · Cellular Signalling · doi:10.1016/j.cellsig.2016.07.015 · Cited by 48 · see citing works
The Immune System in Stroke: Clinical Challenges and Their Translation to Experimental Research
Smith, C. J., Lawrence, C. B., Rodriguez‐Grande, B., Kovács, K., Pradillo, J. M., & Dénes, Á. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9469-1 · Cited by 47 · see citing works
Ahn, J. H., Shin, M. C., Kim, D. W., Kim, H., Song, M., Lee, T.-K., Lee, J., Kim, H., Cho, J. H., Kim, Y., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030554 · Cited by 47 · see citing works
Neuroinflammation and brain–peripheral interaction in ischemic stroke: A narrative review
Cheng, W., Zhao, Q. C., Li, C., & Xu, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1080737 · Cited by 47 · see citing works
LeBlanc, N. J., Guruswamy, R., & ElAli, A. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0478-6 · Cited by 45 · see citing works
Self-citationPan, Q., Liao, X., Liu, H., Wang, Y., Chen, Y., Zhao, B., Lazartigues, E. D., Yang, Y., & Ma, X. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00296.2016 · Cited by 46 · see citing works
Zou, R., Wu, Z., & Cui, S.-Y. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3672 · Cited by 45 · see citing works
Zhang, J., Gao, G., Begum, G., Wang, J., Khanna, A. R., Shmukler, B. E., Daubner, G. M., Heros, P. D. L., Davies, P., Varghese, J., et al. (2016) · Scientific Reports · doi:10.1038/srep35986 · Cited by 45 · see citing works
RetractedExecutive (dys)function after stroke: special considerations for behavioral pharmacology
Povroznik, J. M., Ozga, J. E., Haar, C. V., & Engler-Chiurazzi, E. B. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000432 · Cited by 45 · see citing works
Teekaraman, D., Mohan, M., & Arunakaran, J. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.108795 · Cited by 45 · see citing works
The Molecular Mechanisms of Ferroptosis and Its Role in Blood-Brain Barrier Dysfunction
Chen, X., Pang, X., Yeo, A. J., Xie, S., Xiang, M., Shi, B., Yu, G., & Li, C. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.889765 · Cited by 45 · see citing works
Alluri, H., Stagg, H. W., Wilson, R. L., Clayton, R. P., Sawant, D. A., Koneru, M., Beeram, M., Davis, M. L., & Tharakan, B. (2013) · Microcirculation · doi:10.1111/micc.12110 · Cited by 40 · see citing works
Wnt Pathway: An Emerging Player in Vascular and Traumatic Mediated Brain Injuries
Menet, R., Lecordier, S., & ElAli, A. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.565667 · Cited by 40 · see citing works
Self-citationMani, S., Dubey, R., Lai, I., Babu, M. A., Tyagi, S., Swargiary, G., Mody, D., Singh, M., Agarwal, S., Iqbal, D., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-220700 · Cited by 40 · see citing works
Maurya, S. K., Mishra, J., Tripathi, V., Sharma, R., & Siddiqui, M. H. (2014) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2014.03.005 · Cited by 38 · see citing works
Kim, E., Yang, J., Park, K. W., & Cho, S. (2017) · Translational Stroke Research · doi:10.1007/s12975-017-0601-z · Cited by 38 · see citing works
Jin, F., Hagemann, N., Brockmeier, U., Schäfer, S. T., Zechariah, A., & Hermann, D. M. (2013) · Angiogenesis · doi:10.1007/s10456-013-9340-2 · Cited by 36 · see citing works
Self-citationCNS and peripheral immunity in cerebral ischemia: partition and interaction
Kim, E., & Cho, S. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113508 · Cited by 36 · see citing works
Zhang, Y., Wang, T., Yang, K., Xu, J., Ren, L., Li, W., & Liu, W. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00079 · Cited by 36 · see citing works
Doeppner, T. R., Kaltwasser, B., Teli, M. K., Sánchez-Mendoza, E. H., Kılıç, E., Bähr, M., & Hermann, D. M. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.07.023 · Cited by 32 · see citing works
Self-citationCharradi, K., Mahmoudi, M., Bedhiafi, T., Kadri, S., Elkahoui, S., Limam, F., & Aouani, E. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.01.015 · Cited by 32 · see citing works
Gong, P., Li, R., Jia, H.-Y., Ma, Z., Li, X., Dai, X., & Luo, S. (2019) · Journal of Molecular Neuroscience · doi:10.1007/s12031-019-01402-z · Cited by 32 · see citing works
Oxidized low-density lipoprotein decreases VEGFR2 expression in HUVECs and impairs angiogenesis
Zhang, M., & Jiang, L. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3823 · Cited by 29 · see citing works
Jha, N. K., Kar, R., & Niranjan, R. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666190412121811 · Cited by 29 · see citing works
Molecular mechanisms underlying some major common risk factors of stroke
Alkahtani, R. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e10218 · Cited by 32 · see citing works
Implications of calpains in health and diseases.
Chakraborti, S., Alam, N. H., Paik, D., Shaikh, S., & Chakraborti, T. (2012) · PubMed · Cited by 28 · see citing works
Bernard, M., Menet, R., Lecordier, S., & ElAli, A. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05244-w · Cited by 31 · see citing works
Self-citationDu, L., Fang, C., Wang, Y., Feng, Z., Abiola, O. F., Gao, Z., Huang, J., & Ma, Y. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01505-x · Cited by 27 · see citing works
Aleksandrowicz, M., Konop, M., Rybka, M., Mazurek, Ł., Stradczuk‐Mazurek, M., Kciuk, M., Bądzyńska, B., Dobrowolski, L., & Kuczeriszka, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136467 · Cited by 27 · see citing works
Promoting recovery from ischemic stroke
Schmidt, A., & Minnerup, J. (2015) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2016.1134324 · Cited by 27 · see citing works
What Do Experimental Models Teach Us About Comorbidities in Stroke?
Cho, S., & Yang, J. (2018) · Stroke · doi:10.1161/strokeaha.117.017793 · Cited by 27 · see citing works
Lu, S., Wang, J., He, Z., He, S., Zheng, K., Xu, M., Yuan, S. S., & Wu, Y. (2022) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2022.151553 · Cited by 26 · see citing works
Towner, R. A., Smith, N., Saunders, D., de Souza, P. C., Henry, L., Lupu, F., Silasi‐Mansat, R., Ehrenshaft, M., Mason, R. P., Gomez-Mejiba, S., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.08.004 · Cited by 26 · see citing works
Sh, X., Yin, M.-S., Liu, B., Chen, M.-L., He, G.-W., Zhou, P.-P., Cui, Y.-J., Yang, D. Y., & Wu, Y.-L. (2016) · Human & Experimental Toxicology · doi:10.1177/0960327116657401 · Cited by 26 · see citing works
Preclinical Stroke Research and Translational Failure: A Bird’s Eye View on Preventable Variables
Singh, D., Wasan, H., & Reeta, K. H. (2021) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-021-01083-6 · Cited by 28 · see citing works
Yokobori, S., Frantzén, J., Bullock, R. M., Gajavelli, S., Burks, S. S., Bramlett, H. M., & Dietrich, W. D. (2011) · Therapeutic Hypothermia and Temperature Management · doi:10.1089/ther.2011.0012 · Cited by 25 · see citing works
Yokobori, S., Nakae, R., Yokota, H., Spurlock, M. S., Mondello, S., Gajavelli, S., & Bullock, R. M. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.055 · Cited by 25 · see citing works
Kim, E., Yang, J., Park, K. W., & Cho, S. (2019) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19850004 · Cited by 23 · see citing works
Du, Y., Xu, J.-T., Jin, H., Zhao, R., Zhao, D. H., Du, S., Xue, Y., Xie, X., & Wang, Q. (2017) · Scientific Reports · doi:10.1038/s41598-017-01923-w · Cited by 23 · see citing works
Liu, Y., Hu, X.-B., Zhang, L., Wang, Z., & Fu, R. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00809-w · Cited by 23 · see citing works
Blood brain barrier inflammation and potential therapeutic role of phytochemicals
Welcome, M. O. (2020) · PharmaNutrition · doi:10.1016/j.phanu.2020.100177 · Cited by 22 · see citing works
Du, H., He, Y. T., Zhu, J., Zhou, H., Shao, C., Yang, J., & Wan, H. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114075 · Cited by 21 · see citing works
Wei, W., Yang, W., Shen, Z., Wen, S., & Hu, M. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b05232 · Cited by 21 · see citing works
OKN-007 decreases free radical levels in a preclinical F98 rat glioma model
de Souza, P. C., Smith, N., Atolagbe, O. T., Ziegler, J., Njoku, C., Lerner, M. R., Ehrenshaft, M., Mason, R. P., Meek, B., Plafker, S. M., et al. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.06.026 · Cited by 21 · see citing works
Targeted thrombolysis by magnetoacoustic particles in photothrombotic stroke model
Choi, W., Cho, H., Kim, G., Youn, I., Key, J., & Han, S. (2022) · Biomaterials Research · doi:10.1186/s40824-022-00298-y · Cited by 20 · see citing works
Chirico, E. N., Cataldo, V. D., Chauveau, F., Géloën, A., Patsouris, D., Thezé, B., Martin, C., Vidal, H., Rieusset, J., Pialoux, V., et al. (2016) · The Journal of Physiology · doi:10.1113/jp271903 · Cited by 19 · see citing works
Chen, S., Chen, Z., Cui, J., MCCRARY, M. L., Song, H., Mobashery, S., Chang, M., & Gu, Z. (2018) · eNeuro · doi:10.1523/eneuro.0391-17.2018 · Cited by 19 · see citing works
Noscapine alleviates cerebral damage in ischemia-reperfusion injury in rats
Kawadkar, M., Mandloi, A. S., Saxena, V., Tamadaddi, C., Sahi, C., & Dhote, V. V. (2020) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-020-02005-x · Cited by 19 · see citing works
Intravascular Perfusion of Carbon Black Ink Allows Reliable Visualization of Cerebral Vessels
Hasan, M. R., Herz, J., Hermann, D. M., & Doeppner, T. R. (2013) · Journal of Visualized Experiments · doi:10.3791/4374 · Cited by 18 · see citing works
Self-citationThe neuroprotective effect of focused ultrasound: New perspectives on an old tool
Yuluğ, B., Hanoğlu, L., & Kılıç, E. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.04.015 · Cited by 17 · see citing works
Shi, S. R., Liu, Z., Xue, Z., Chen, X., & Chu, Y. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112780 · Cited by 17 · see citing works
Neuroprotective effects of combined trimetazidine and progesterone on cerebral reperfusion injury
Dhote, V. V., Mandloi, A. S., Singour, P. K., Kawadkar, M., Ganeshpurkar, A., & Jadhav, M. P. (2022) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2022.100108 · Cited by 16 · see citing works
Zeng, J., Cao, J., Yang, H., Wang, X., Liu, T., Chen, Z., Shi, F., Xu, Z., & Lin, X. (2024) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14920 · Cited by 16 · see citing works
Gu, Y., Huang, P. C., Li, Q., Liu, Y., Liu, C., Wang, Y., Yi, M., Yan, L., Wei, X., Yang, L., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00658 · Cited by 16 · see citing works
Snelson, M., Mamo, J. C. L., Lam, V., Giles, C., & Takechi, R. (2017) · Frontiers in Nutrition · doi:10.3389/fnut.2017.00035 · Cited by 16 · see citing works
Promoting Neurological Recovery in the Post-Acute Stroke Phase: Benefits and Challenges
Hermann, D. M., & Chopp, M. (2014) · European Neurology · doi:10.1159/000365171 · Cited by 14 · see citing works
Self-citationDi Cataldo, V., Géloën, A., Langlois, J.-B., Chauveau, F., Thézé, B., Hubert, V., Wiart, M., Chirico, E. N., Rieusset, J., Vidal, H., et al. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00453 · Cited by 15 · see citing works
Khowdiary, M. M., Al-Kuraishy, H. M., Al-Gareeb, A. I., Albuhadily, A. K., Elhenawy, A. A., Rashwan, E. K., Alexiou, A. T., Papadakis, M., Fetoh, M. E. A., & Batiha, G. E. (2025) · NeuroMolecular Medicine · doi:10.1007/s12017-025-08836-2 · Cited by 15 · see citing works
Alawneh, K. Z. A., Qawasmeh, M. A., Raffee, L. A., & Al-Mistarehi, A.-H. W. (2022) · Future Science OA · doi:10.2144/fsoa-2022-0017 · Cited by 14 · see citing works
Zhang, S., Zhao, D., Yang, Z., Wang, F., Yang, S., & Wang, C. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03013-x · Cited by 15 · see citing works
de Carvalho, T. S., Sánchez-Mendoza, E. H., Melo, L. M. N., Moreira, A. R. S., Sardari, M., Dzyubenko, E., Kleinschnitz, C., & Hermann, D. M. (2019) · Translational Stroke Research · doi:10.1007/s12975-019-00700-3 · Cited by 14 · see citing works
Self-citationTuz, A. A., Hoerenbaum, N., Ulusoy, Ö., Ahmadi, A., Gerlach, A., Beer, A., Kraus, A., Hasenberg, A., Hagemann, N., Hermann, D. M., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1502346 · Cited by 13 · see citing works
Self-citationHermann, D. M., Wang, C., Yusuf, A. M., Herz, J., Doeppner, T. R., & Giebel, B. (2025) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x251325039 · Cited by 14 · see citing works
Self-citationCREB Coactivator CRTC2 Plays a Crucial Role in Endothelial Function
Kanki, H., Sasaki, T., Matsumura, S., Kawano, T., Todo, K., Okazaki, S., Nishiyama, K., Takemori, H., & Mochizuki, H. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0407-20.2020 · Cited by 13 · see citing works
- Authors
- ElAli, A., Doeppner, T. R., Zechariah, A., & Hermann, D. M.
- Affiliations
- Essen University Hospital (DE)
- Venue
- Stroke
- Published
- 2011-11
- Volume
- 42
- Issue
- 11
- Pages
- 3238-3244
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2104832976
- Cited by
- 150
- References
- 26
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 11 · 2023: 7 · 2022: 14 · 2021: 7 · 2020: 12 · 2019: 10 · 2018: 6 · 2017: 11 · 2016: 17 · 2015: 5 · 2014: 10 · 2013: 12 · 2012: 9
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- hyperlipidemia, blood-brain barrier permeability, cerebral edema, focal cerebral ischemia, ischemic stroke, middle cerebral artery occlusion, apolipoprotein E deficiency, high-cholesterol diet, IgG extravasation, lipid peroxidation, LDL oxidation, MMP2/9, RhoA, occludin, tight junctions, ischemia-reperfusion injury
- MeSH terms
- Animals, Blood-Brain Barrier, Brain Edema, Calpain, Capillary Permeability, Brain Ischemia, Enzyme Activation, Hyperlipidemias, Male, Mice, Inbred C57BL, Lipid Peroxidation, Mice, Knockout, rho GTP-Binding Proteins, rhoA GTP-Binding Protein, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review