The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Arterial Stiffness and Cerebral Small Vessel Disease: The Rotterdam Scan Study
Open accessAbstract
Background and Purpose—: Aging and vascular risk factors contribute to arterial stiffening. Increased arterial stiffness exposes the small vessels in the brain to abnormal flow pulsations and, as such, may contribute to the pathogenesis of cerebral small vessel disease. In a population-based study, we investigated the association between arterial stiffness, as measured by aortic pulse wave velocity (aPWV), and small vessel disease. Methods—: Overall, 1460 participants (mean age, 58.2 years) underwent aPWV measurement and brain MRI scanning. We calculated aPWV by measuring time differences and distances between pulse waves in the carotid and femoral arteries. Using automated MRI analysis, we obtained white matter lesion volumes. Infarcts and microbleeds were rated visually. We used linear and logistic regression models to associate aPWV with small vessel disease, adjusting for age, sex, mean arterial pressure, and heart rate and additionally for cardiovascular risk factors. Subsequently, we explored associations in strata of hypertension. Results—: In the study group, higher aPWV was associated with larger white matter lesion volume (difference in volume per SD increase in aPWV 0.07; 95% CI, 0.02–0.12) but not with lacunar infarcts or microbleeds. In persons with uncontrolled hypertension, higher aPWV was significantly associated with larger white matter lesion volume (difference in volume per SD increase in aPWV 0.09; 95% CI, 0.00–0.18), deep or infratentorial microbleeds (OR, 2.13; 95% CI, 1.16–3.91), and to a lesser extent also with lacunar infarcts (OR, 1.63; 95% CI, 0.98–2.70). No such associations were present in persons with controlled hypertension or without hypertension. Conclusions—: In our study, increased arterial stiffness is associated with a larger volume of white matter lesions.
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Expert consensus document on arterial stiffness: methodological issues and clinical applications
Laurent, S., Cockcroft, J., Van Bortel, L., Boutouyrie, P., Giannattasio, C., Hayoz, D., Pannier, B., Vlachopoulos, C., Wilkinson, I., Struijker-Boudier, H., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl254 · Cited by 6,077
Arterial Stiffness and Risk of Coronary Heart Disease and Stroke: The Rotterdam Study
Mattace-Raso, F. U. S., van der Cammen, T. J. M., Hofman, A., van Popele, N. M., Bos, M. L., Schalekamp, M. A. D. H., Asmar, R., Reneman, R. S., Hoeks, A. P. G., Breteler, M. M. B., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.555235 · Cited by 1,914 · cited 1×
“In line with previous studies suggesting differential effects of arterial stiffness according to blood pressure,1,16 we defined 3 categories of hypertension: (1) no hypertension (systolic blood pressure 140 mm Hg and a diastolic blood pressure 90 mm Hg without use of antihypertensive medication); (2) controlled hypert…”
ResultSelf-citationCerebral microbleeds: a guide to detection and interpretation
Greenberg, S. M., Vernooij, M. W., Cordonnier, C., Viswanathan, A., Al-Shahi Salman, R., Warach, S., Launer, L. J., Van Buchem, M. A., & Breteler, M. M. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70013-4 · Cited by 1,798
Self-citationO’Rourke, M. F., & Safar, M. E. (2005) · Hypertension · doi:10.1161/01.hyp.0000168052.00426.65 · Cited by 1,279
Incidence and Risk Factors of Silent Brain Infarcts in the Population-Based Rotterdam Scan Study
Vermeer, S. E., den Heijer, T., Koudstaal, P. J., Oudkerk, M., Hofman, A., & Breteler, M. M. B. (2003) · Stroke · doi:10.1161/01.str.0000052631.98405.15 · Cited by 680
Self-citationPrevalence and Risk Factors of Cerebral Microbleeds: An Update of the Rotterdam Scan Study
Poels, M. M. F., Vernooij, M. W., Ikram, M. A., Hofman, A., Krestin, G. P., van der Lugt, A., & Breteler, M. M. B. (2010) · Stroke · doi:10.1161/strokeaha.110.595181 · Cited by 563
Self-citationPrevalence and Risk Factors of Silent Brain Infarcts in the Population-Based Rotterdam Scan Study
Vermeer, S. E., Koudstaal, P. J., Oudkerk, M., Hofman, A., & Breteler, M. M. B. (2002) · Stroke · doi:10.1161/hs0102.101629 · Cited by 430
Self-citationHenskens, L. H. G., Kroon, A. A., van Oostenbrugge, R. J., Gronenschild, E. H. B. M., Fuss-Lejeune, M. M. J. J., Hofman, P. A. M., Lodder, J., & de Leeuw, P. W. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.119024 · Cited by 293
Kearney-Schwartz, A., Rossignol, P., Bracard, S., Felblinger, J., Fay, R., Boivin, J.-M., Lecompte, T., Lacolley, P., Benetos, A., & Zannad, F. (2009) · Stroke · doi:10.1161/strokeaha.108.532853 · Cited by 274
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Lung disease as a determinant of cognitive decline and dementia
Dodd, J. W. (2015) · Alzheimer's Research & Therapy · doi:10.1186/s13195-015-0116-3 · Cited by 192
White matter integrity in physically fit older adults.
Tseng, B. Y., Gundapuneedi, T., Khan, M. A., Diaz-Arrastia, R., Levine, B. D., Lu, H., Huang, H., & Zhang, R. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.06.011 · Cited by 157
Impact of cardiovascular hemodynamics on cognitive aging
Moore, E. E., & Jefferson, A. L. (2021) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.120.311909 · Cited by 49
Song, T. ‐., Kim, J., Kim, Y. D., Nam, H. S., Lee, H. S., Nam, C. M., & Heo, J. H. (2014) · European Journal of Neurology · doi:10.1111/ene.12332 · Cited by 49
Metadata
- Authors
- Poels, M. M. F., Zaccai, K., Verwoert, G. C., Vernooij, M. W., Hofman, A., van der Lugt, A., Witteman, J. C. M., Breteler, M. M. B., Mattace-Raso, F. U. S., & Ikram, M. A.
- Venue
- Stroke
- Published
- 2012-10
- Volume
- 43
- Issue
- 10
- Pages
- 2637-2642
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2086504513
- Cited by
- 253
- References
- 9
- FWCI
- 11.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Poels, M. M. F., Zaccai, K., Verwoert, G. C., Vernooij, M. W., Hofman, A., van der Lugt, A., Witteman, J. C. M., Breteler, M. M. B., Mattace-Raso, F. U. S., & Ikram, M. A. (2012). Arterial Stiffness and Cerebral Small Vessel Disease: The Rotterdam Scan Study. Stroke. https://doi.org/10.1161/strokeaha.111.642264
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
