Vascular Cell Senescence Contributes to Blood–Brain Barrier Breakdown

Yamazaki, Yu, Baker, Darren J., Tachibana, Masaya, Liu, Chia-Chen, van Deursen, Jan M., Brott, Thomas G., Bu, Guojun, Kanekiyo, Takahisa·2016·Stroke

Cited by (263)

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  2. Endothelial Senescence and Chronic Fatigue Syndrome, a COVID-19 Based Hypothesis
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  3. Long-term cilostazol administration ameliorates memory decline in senescence-accelerated mouse prone 8 (SAMP8) through a dual effect on cAMP and blood-brain barrier
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  4. Cerebral Microvascular Senescence and Inflammation in Diabetes
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  5. Cellular senescence and failure of myelin repair in multiple sclerosis
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  9. Senescence-associated microvascular endothelial dysfunction: A focus on the blood-brain and blood-retinal barriers
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  10. Navigating oligodendrocyte precursor cell aging in brain health
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  11. Simplified in vitro 3D co-culture-based blood-brain barrier model using transwell
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  13. Among Gerontogens, Heavy Metals Are a Class of Their Own: A Review of the Evidence for Cellular Senescence
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  14. Early to Long-Term Alterations of CNS Barriers After Traumatic Brain Injury: Considerations for Drug Development
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  15. Natural aging and Alzheimer’s disease pathology increase susceptibility to focused ultrasound-induced blood–brain barrier opening
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  16. Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments
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  17. Nanomechanical insights: Amyloid beta oligomer-induced senescent brain endothelial cells
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  19. Brown rats on farmland
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  20. Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction
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  21. LSEC model of aging
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  24. Application of Oxidative Stress to a Tissue-Engineered Vascular Aging Model Induces Endothelial Cell Senescence and Activation
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  26. Vascular contributions to cognitive impairment/dementia in diabetes: role of endothelial cells and pericytes
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  27. LRP1 in vascular mural cells modulates cerebrovascular integrity and function in the presence of APOE4
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  30. Vascular ageing in hypertension: Focus on mitochondria
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  43. Roles of TSP1-CD47 signaling pathway in senescence of endothelial cells: cell cycle, inflammation and metabolism
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  44. The blood-brain interface: a culture change
    Ian Galea, Victor Hugh Perry · 2017 · Brain Behavior and Immunity
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  50. The crosstalk between cellular reprogramming and senescence in aging and regeneration
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