Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline
Open accessAbstract
The adult mammalian brain contains distinct neurogenic niches harboring populations of neural stem cells (NSCs) with the capacity to sustain the generation of specific subtypes of neurons during the lifetime. However, their ability to produce new progeny declines with age. The microenvironment of these specialized niches provides multiple cellular and molecular signals that condition NSC behavior and potential. Among the different niche components, vasculature has gained increasing interest over the years due to its undeniable role in NSC regulation and its therapeutic potential for neurogenesis enhancement. NSCs are uniquely positioned to receive both locally secreted factors and adhesion-mediated signals derived from vascular elements. Furthermore, studies of parabiosis indicate that NSCs are also exposed to blood-borne factors, sensing and responding to the systemic circulation. Both structural and functional alterations occur in vasculature with age at the cellular level that can affect the proper extrinsic regulation of NSCs. Additionally, blood exchange experiments in heterochronic parabionts have revealed that age-associated changes in blood composition also contribute to adult neurogenesis impairment in the elderly. Although the mechanisms of vascular- or blood-derived signaling in aging are still not fully understood, a general feature of organismal aging is the accumulation of senescent cells, which act as sources of inflammatory and other detrimental signals that can negatively impact on neighboring cells. This review focuses on the interactions between vascular senescence, circulating pro-senescence factors and the decrease in NSC potential during aging. Understanding the mechanisms of NSC dynamics in the aging brain could lead to new therapeutic approaches, potentially include senolysis, to target age-dependent brain decline.
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Vascular and endothelial cells of the blood-brain barrier have demonstrated senescence properties.
“Vascular and endothelial cells of the blood-brain barrier have also demonstrated senescence properties [37,38].”
From Untangling senescent and damage‐associated microglia in the aging and diseased brain (2023) · cites this paper as [38]
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Untangling senescent and damage‐associated microglia in the aging and diseased brain
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- Authors
- Rojas-Vázquez, S., Blasco-Chamarro, L., López-Fabuel, I., Martínez-Máñez, R., & Fariñas, I.
- Affiliations
- Universitat de València (ES)
- Corresponding author
- Fariñas, Isabel
- Venue
- Frontiers in Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2021-04-20
- Volume
- 15
- Pages
- 666881-666881
- ISSN
- 1662-453X (ISSN-L)
- PMC
- PMC8093510
- OpenAlex
- W3152931419
- Cited by
- 15
- References
- 149
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 3
- FWCI
- 0.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- RiuNet (Universitat Politècnica de València) (submittedVersion, cc-by-nc-nd)
- Funders
- Generalitat Valenciana (PROMETEO/2018/024, Prometeo 2017-030, 2018/024, RTI2018-100910-B-C41)
- Ministerio de Ciencia e Innovación (RED2018-102723-T, RTI2018-100910-B-C41, RTI2018, RD16/0011/0017, CB06/05/0086)
- Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
- Instituto de Salud Carlos III (RD16/0011, CIBERNED CB06/05/0086, RD16/0011/0017, CB06/05/0086, RTI2018-100910-B-C41, RED2018-102723-T)
- Agencia Estatal de Investigación (SAF2017-86690-R, RED2018-102723-T, RTI2018-100910-B-C41)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- vascular aging, neural stem cells, adult neurogenesis, brain aging, neurogenic niche, parabiosis, blood-borne factors, senescence-associated secretory phenotype, senolysis, age-related decline
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