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Cited by 21Ethics in Clinical ResearchInterpreting and Communication in HealthcareAcute Ischemic Stroke Management

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

A Dedicated Spanish Language Line Increases Enrollment of Hispanics Into Prehospital Clinical Research

Sanossian, Nerses, Rosenberg, Lauren, Liebeskind, David S., Starkman, Sidney, Eckstein, Marc, Stratton, Samuel, Pratt, Franklin D., Hamilton, Scott, Kim-Tenser, May, Sharma, Latisha K., Restrepo, Lucas, Valdes-Suieras, Miguel, Conwit, Robin, Saver, Jeffrey L.·2017·Stroke
DOI 10.1161/strokeaha.117.014745
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Abstract

Background and Purpose—: Novel methods are needed to reduce the disparity of Hispanic enrollment in stroke clinical trials. Prehospital enrollment using a dedicated Spanish language line may help overcome this bias. Methods—: Subjects or legally authorized representatives provided information on race and ethnicity for all cases enrolled in the FAST-MAG clinical trial (Field Administration of Stroke Therapy-Magnesium), a prehospital phase 3 randomized study of intravenous magnesium for neuroprotection. One of 2 in-ambulance cell phones (in English or Spanish) was used to obtain informed content in the field. We describe the yield and characteristics of subjects enrolled via Spanish line. Results—: There were 1700 subjects enrolled from 2005 to 2012, of which 402 (24%) identified as Hispanic ethnicity. Study racial makeup was 1325 (78%) white, 219 (13%) black, and 139 (8%) Asian. The dedicated Spanish line was used for 195 (12%) enrollments. Spanish-line enrollments were younger (65 versus 70 years old; P <0.001), more likely to identify as Hispanic (98% versus 14%; P <0.001), and more likely to present with intracerebral hemorrhage (36% versus 21%; P <0.001). Conclusions—: The use of a dedicated Spanish language enrollment line allowed for greater enrollment of Hispanics, a population with significantly different baseline characteristics. Clinical Trial Registration—: URL: http://www.clinicaltrials.gov . Unique identifier: NCT00059332.

Overview

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Crossref · 10.1161/strokeaha.117.014745

Cites

12 of 12 references verified0 citation errors · 0 not checkable

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  • A total of 12 included articles were assessed with an MMAT score below 3, including two RCTs, three non-randomised studies, six quantitative descriptive studies and one mixed methods study.

    “A total of 12 articles were assessed with a score of below 3. This included two RCTs [61, 66], three non-randomised studies [15, 46, 64], six quantitative descriptive studies [9, 37, 38, 40, 57, 58] and one mixed methods study [60].”

    From Enablers and barriers of clinical trial participation in adult patients from minority ethnic groups: a systematic review (2025) · cites this paper as [15]

  • Seven included studies centred on the recruitment of Hispanic or Latin American individuals.

    “Although 7 studies centred on the recruitment of Hispanic or Latin American individuals [12, 15, 36, 50, 51, 57, 66], most of them did not differentiate between the terms Hispanic”

    From Enablers and barriers of clinical trial participation in adult patients from minority ethnic groups: a systematic review (2025) · cites this paper as [15]

  • Present-day challenges such as language barriers, cultural differences and a lack of cultural competence can make it difficult for researchers to rebuild trust and establish clear communication with potential participants.

    “Beyond these historical issues, present-day challenges such as language barriers, cultural differences and a lack of cultural competence can make it difficult for researchers to effectively rebuild trust and establish clear communication with potential participants [14–17].”

    From Enablers and barriers of clinical trial participation in adult patients from minority ethnic groups: a systematic review (2025) · cites this paper as [15]

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Metadata

Authors
Sanossian, N., Rosenberg, L., Liebeskind, D. S., Starkman, S., Eckstein, M., Stratton, S., Pratt, F. D., Hamilton, S., Kim-Tenser, M., Sharma, L. K., Restrepo, L., Valdes-Suieras, M., Conwit, R., & Saver, J. L.
Affiliations
  • University of Southern California (US)
  • From the Departments of Neurology (N.S., L.R., M.K.-T.) and Emergency Medicine (M.E.), University of Southern California, Los Angeles; UCLA Stroke Center, Los Angeles, CA (D.S.L., S.S., L.K.S., L.R., M.V.-S., J.L.S.); School of Public Health, University of California Los Angeles (S.S.); Los Angeles County Fire Department, CA (F.D.P.); Stanford University, CA (S.H.); and National Institutes of Health, Bethesda, MD (R.C.).
ORCID
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2017-05
Volume
48
Issue
5
Pages
1389-1391
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
DOI
10.1161/strokeaha.117.014745
OpenAlex
W2604259122
Cited by
21
References
12
Citations by year
2026: 1 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 4 · 2020: 1 · 2019: 1
FWCI
0.51
Type
journal article
Language
en
Open access
closed
Locations
  • Stroke (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (U01NS044364)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
  • Health Sciences › Health Professions › General Health Professions › Interpreting and Communication in Healthcare
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords
language barriers, stroke clinical trials, FAST-MAG trial, intravenous magnesium, neuroprotection, racial and ethnic disparities, intracerebral hemorrhage
MeSH terms
Aged, Aged, 80 and over, California, Cerebral Hemorrhage, Clinical Trials as Topic, Emergency Medical Technicians, Female, Hispanic or Latino, Humans, Language, Magnesium, Male, Middle Aged, Patient Selection, Neuroprotective Agents, Stroke, Biomedical Research, Cell Phone, Culturally Competent Care

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