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Cited by 323

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

Effectiveness and Safety of Oral Anticoagulants Among Nonvalvular Atrial Fibrillation Patients: The ARISTOPHANES Study

Open access
Lip, Gregory Y.H., Keshishian, Allison, Li, Xiaoyan, Hamilton, Melissa, Masseria, Cristina, Gupta, Kiran, Luo, Xuemei, Mardekian, Jack, Friend, Keith, Nadkarni, Anagha, Pan, Xianying, Baser, Onur, Deitelzweig, Steven·2018·Stroke
DOI 10.1161/strokeaha.118.020232
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Abstract

Background and Purpose—: This ARISTOPHANES study (Anticoagulants for Reduction in Stroke: Observational Pooled Analysis on Health Outcomes and Experience of Patients) used multiple data sources to compare stroke/systemic embolism (SE) and major bleeding (MB) among a large number of nonvalvular atrial fibrillation patients on non–vitamin K antagonist oral anticoagulants (NOACs) or warfarin. Methods—: A retrospective observational study of nonvalvular atrial fibrillation patients initiating apixaban, dabigatran, rivaroxaban, or warfarin from January 1, 2013, to September 30, 2015, was conducted pooling Centers for Medicare and Medicaid Services Medicare data and 4 US commercial claims databases. After 1:1 NOAC-warfarin and NOAC-NOAC propensity score matching in each database, the resulting patient records were pooled. Cox models were used to evaluate the risk of stroke/SE and MB across matched cohorts. Results—: A total of 434 046 patients were included in the 6 matched cohorts: 100 977 apixaban-warfarin, 36 990 dabigatran-warfarin, 125 068 rivaroxaban-warfarin, 37 314 apixaban-dabigatran, 107 236 apixaban-rivaroxaban, and 37 693 dabigatran-rivaroxaban patient pairs. Apixaban (hazard ratio [HR], 0.64; 95% CI, 0.58–0.70), dabigatran (HR, 0.82; 95% CI, 0.71–0.95), and rivaroxaban (HR, 0.79; 95% CI, 0.73–0.85) were associated with lower rates of stroke/SE compared with warfarin. Apixaban (HR, 0.60; 95% CI, 0.56–0.63) and dabigatran (HR, 0.71; 95% CI, 0.65–0.78) had lower rates of MB, and rivaroxaban (HR, 1.06; 95% CI, 1.02–1.10) had a higher rate of MB compared with warfarin. Differences exist in rates of stroke/SE and MB across NOACs. Conclusions—: In this largest observational study to date on NOACs and warfarin, the NOACs had lower rates of stroke/SE and variable comparative rates of MB versus warfarin. The findings from this study may help inform the discussion on benefit and risk in the shared decision-making process for stroke prevention between healthcare providers and nonvalvular atrial fibrillation patients. Clinical Trial Registration—: URL: https://www.clinicaltrials.gov/ . Unique identifier: NCT03087487.

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Metadata

Authors
Lip, G. Y. H., Keshishian, A., Li, X., Hamilton, M., Masseria, C., Gupta, K., Luo, X., Mardekian, J., Friend, K., Nadkarni, A., Pan, X., Baser, O., & Deitelzweig, S.
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2018-12
Volume
49
Issue
12
Pages
2933-2944
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
DOI
10.1161/strokeaha.118.020232
OpenAlex
W2899640924
Cited by
323
References
38
FWCI
28.39
Type
journal article
Language
en
Open access
hybrid

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