Sleep-Disordered Breathing Is Associated With Recurrent Ischemic Stroke
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Background and Purpose—: Limited data are available about the relationship between sleep-disordered breathing (SDB) and recurrent stroke and mortality, especially from population-based studies, large samples, or ethnically diverse populations. Methods—: In the BASIC project (Brain Attack Surveillance in Corpus Christ), we identified patients with ischemic stroke (2010–2015). Subjects were offered screening for SDB with the ApneaLink Plus device, from which a respiratory event index (REI) score ≥10 defined SDB. Demographics and baseline characteristics were determined from chart review and interview. Recurrent ischemic stroke was identified through active and passive surveillance. Cause-specific proportional hazards models were used to assess the association between REI (modeled linearly) and ischemic stroke recurrence (as the event of interest), and all-cause poststroke mortality, adjusted for multiple potential confounders. Results—: Among 842 subjects, the median age was 65 (interquartile range, 57–76), 47% were female, and 58% were Mexican American. The median REI score was 14 (interquartile range, 6–26); 63% had SDB. SDB was associated with male sex, Mexican American ethnicity, being insured, nonsmoking status, diabetes mellitus, hypertension, lower educational attainment, and higher body mass index. Among Mexican American and non-Hispanic whites, 85 (11%) ischemic recurrent strokes and 104 (13%) deaths occurred, with a median follow-up time of 591 days. In fully adjusted models, REI was associated with recurrent ischemic stroke (hazard ratio, 1.02 [hazard ratio for one-unit higher REI score, 95% CI, 1.01–1.03]), but not with mortality alone (hazard ratio, 1.00 [95% CI, 0.99–1.02]). Conclusions—: Results from this large population-based study show that SDB is associated with recurrent ischemic stroke, but not mortality. SDB may therefore represent an important modifiable risk factor for poor stroke outcomes.
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Obstructive sleep apnea is an independent risk factor for incident stroke, stroke recurrence, mortality, and functional and cognitive outcomes.
“OSA is not only an independent risk factor for incident stroke 37 but also an independent risk factor for stroke recurrence, 38 mortality, and functional and cognitive outcomes.39”
From Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association (2021) · cites this paper as [38]
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- Authors
- Brown, D. L., Shafie-Khorassani, F., Kim, S., Chervin, R. D., Case, E., Morgenstern, L. B., Yadollahi, A., Tower, S., & Lisabeth, L. D.
- Affiliations
- University of Michigan (US)
- Department of Biostatistics (F.S.-K., S.K.), School of Public Health, University of Michigan, Ann Arbor
- University Health Network (CA)
- CHRISTUS Spohn Hospital Corpus Christi - Memorial (US)
- ORCID
- Venue
- Stroke
- Published
- 2019-03
- Volume
- 50
- Issue
- 3
- Pages
- 571-576
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- PMC
- PMC6389387
- OpenAlex
- W2911371516
- Cited by
- 121
- References
- 30
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 16 · 2023: 21 · 2022: 22 · 2021: 16 · 2020: 9 · 2019: 11
- FWCI
- 9.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Cambridge
- National Heart, Lung, and Blood Institute (T32HL110952, R01HL105999, R01HL098065, U01HL125295, R01HL123379, R01HL126700, R43HL117421)
- National Institute of Diabetes and Digestive and Kidney Diseases (U01DK062456, R01DK070869)
- National Institute of Neurological Disorders and Stroke (R01NS091112, R01NS070941, R01NS038916, U01NS099043)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD082129)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- sleep-disordered breathing, recurrent ischemic stroke, post-stroke mortality, respiratory event index, modifiable risk factors, stroke outcome, basic project
- MeSH terms
- Aged, Brain Ischemia, Ethnicity, Female, Humans, Male, Middle Aged, Population Surveillance, Recurrence, Risk Factors, Sleep Apnea Syndromes, United States, Proportional Hazards Models, Mexican Americans, Stroke, White People
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