The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Elevated levels of exhaled nitric oxide in bronchiectasis.
Abstract
Bronchiectasis is characterized by chronic inflammation in one or more bronchi, but the extent of inflammation is difficult to monitor. The concentration of nitric oxide (NO) in exhaled air is increased in asthmatic patients, possibly as a result of the chronic inflammatory process. We have measured exhaled NO in patients with documented bronchiectasis and investigated whether the concentration of exhaled NO is related to the extent of disease as defined by computed tomography (CT) and lung function. In 20 patients with bronchiectasis who were not taking inhaled steroids, the peak concentration of NO in exhaled air, measured by a modified chemiluminescence analyzer, was significantly elevated (285 +/- 49.0 ppb) as compared with values for 79 normal subjects (89 +/- 2.7 ppb, p < 0.01) and 19 patients with bronchiectasis treated with inhaled steroids (88 +/- 13.4 ppb, p < 0.01). Thin-section CT was used to quantify the extent of bronchiectasis in the 19 patients. There was a significant correlation between the CT score and FEV1 (r = 0.73, p < 0.01). In patients not treated with inhaled steroids there was a significant relationship between CT score and peak exhaled NO (r = 0.81, n = 12, p < 0.02), but this was not the case for patients treated with regular inhaled steroids (n = 7). We conclude that untreated bronchiectasis is associated with an increase in exhaled NO, and that this is correlated with disease severity, whereas patients treated with inhaled steroids have levels of exhaled NO within the normal range.(ABSTRACT TRUNCATED AT 250 WORDS)
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Cites
The L-Arginine-Nitric Oxide Pathway
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Nitric oxide as a secretory product of mammalian cells
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Increased nitric oxide in exhaled air of asthmatic patients
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Self-citationEndogenous nitric oxide is present in the exhaled air of rabbits, guinea pigs and humans
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Induction of nitric oxide synthase in asthma
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Nitric Oxide Synthase in Human and Rat Lung: Immunocytochemical and Histochemical Localization
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Cited by
(2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200406-710st · Cited by 3,203
Nitric oxide in health and disease of the respiratory system
Ricciardolo, F. L. M., Sterk, P. J., Gaston, B., & Folkerts, G. (2004) · Physiological Reviews · doi:10.1152/physrev.00034.2003 · Cited by 903
Exhaled nitric oxide measurements: clinical application and interpretation
Taylor, D. R., Pijnenburg, M. W., Smith, A. D., & Jongste, J. C. D. (2006) · Thorax · doi:10.1136/thx.2005.056093 · Cited by 507
Metadata
- Authors
- Kharitonov, S. A., Wells, A. U., O'Connor, B. J., Cole, P. J., Hansell, D. M., Logan-Sinclair, R. B., & Barnes, P. J.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-06
- Volume
- 151
- Issue
- 6
- Pages
- 1889-1893
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1964187430
- Cited by
- 306
- References
- 17
- FWCI
- 27.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kharitonov, S. A., Wells, A. U., O'Connor, B. J., Cole, P. J., Hansell, D. M., Logan-Sinclair, R. B., & Barnes, P. J. (1995). Elevated levels of exhaled nitric oxide in bronchiectasis. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.151.6.7767536
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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