The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Titration of tidal volume and induced hypercapnia in acute respiratory distress syndrome.
Abstract
Mechanical ventilation may promote overdistension-induced pulmonary lesions in patients with acute respiratory distress syndrome (ARDS). The static pressure-volume (P-V) curve of the respiratory system can be used to determine the lung volume and corresponding static airway pressure at which lung compliance begins to diminish (the upper inflection point, or UIP). This fall in compliance may indicate overdistension of lung units. We prospectively studied 42 patients receiving mechanical ventilation with an FIO2 of 0.5 or more for at least 24 h. According to the Lung Injury Score (LIS), 25 patients were classified as having ARDS (LIS > 2.5), while 17 patients constituted a non-ARDS control group. The P-V curve was obtained every 2 d. Mechanical ventilation initially used standard settings (volume-control mode, a positive end-expiratory pressure [PEEP] adjusted to the lower inflection point on the P-V curve, and a tidal volume [VT] of 10 ml/kg). The end-inspiratory plateau pressure (Pplat) was compared to the UIP, and VT was lowered when the Pplat was above the UIP. In the range of lung volume studied on the P-V curves (up to 1600 ml), a UIP could be shown in only one control patient (at 23 cm H2O). By contrast, a UIP was present on the P-V curve obtained from all patients with ARDS, corresponding to a mean airway pressure of 26 +/- 6 cm H2O, a lung volume of 850 +/- 200 ml above functional residual capacity and 610 +/- 235 ml above PEEP.(ABSTRACT TRUNCATED AT 250 WORDS)
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Cites
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Metadata
- Authors
- Roupie, E., Dambrosio, M., Servillo, G., Mentec, H., el Atrous, S., Beydon, L., Brun-Buisson, C., Lemaire, F., & Brochard, L.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1995-07
- Volume
- 152
- Issue
- 1
- Pages
- 121-128
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1984842364
- Cited by
- 327
- References
- 24
- FWCI
- 24.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Titration of tidal volume and induced hypercapnia in acute respiratory distress syndrome. https://app.cochat.ai/papers/10.1164/ajrccm.152.1.7599810
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- Roupie, E., Dambrosio, M., Servillo, G., Mentec, H., el Atrous, S., Beydon, L., Brun-Buisson, C., Lemaire, F., & Brochard, L. (1995). Titration of tidal volume and induced hypercapnia in acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.152.1.7599810
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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