Beneficial Effects of the "Open Lung Approach" With Low Distending Pressures in Acute Respiratory Distress Syndrome. A Prospective Randomized Study on Mechanical Ventilation

Amato, M B; Barbas, C S; Medeiros, D M; Schettino, G de P; Lorenzi Filho, G; Kairalla, R A; Deheinzelin, D; Morais, C; Fernandes, E de O; Takagaki, T Y

doi:10.1164/ajrccm.152.6.8520744

Beneficial Effects of the "Open Lung Approach" With Low Distending Pressures in Acute Respiratory Distress Syndrome. A Prospective Randomized Study on Mechanical Ventilation

Alveolar overdistention and cyclic reopening of collapsed alveoli have been implicated in the lung damage found in animals submitted to artificial ventilation. To test whether these phenomena are impairing the recovery of patients with acute respiratory distress syndrome (ARDS) submitted to conve…