The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Interactions between neutrophils and cytokines in blood and alveolar spaces during ARDS.
Abstract
Although the pathogenesis of the acute respiratory distress syndrome (ARDS) is complex and poorly understood, several observations point to an important role of interactions between polymorphonuclear neutrophils (PMN) and cytokines in this process. We therefore studied certain parameters involved in PMN transendothelial migration (adhesion molecule expression and cytoskeletal organization) in patients with ARDS (n = 14) in comparison with other ventilated patients (n = 15). We found that in the basal state, both whole-blood PMN and alveolar PMN obtained by bronchoalveolar lavage (BAL) were activated, as shown by decreased L-selectin CD62L and increased beta 2 integrin CD11b expression, as well as decreased F-actin content. The degree of PMN activation increased with the degree of lung injury and with the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-8 (IL-8). Moreover, the capacity of ex vivo stimulation of alveolar PMN by a bacterial peptide was low in ARDS and could partly account for the high susceptibility of these patients to lung infection. Therefore, ARDS-associated lung injury could be caused, at least in part, by inappropriate adhesion and transendothelial migration of proinflammatory cytokine-primed PMN.
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Cites
Berkow, R. L., Wang, D., Larrick, J. W., Dodson, R. W., & Howard, T. H. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.11.3783 · Cited by 295
Cited by
Ventilator-Associated Pneumonia
(2012) · SpringerReference · doi:10.1007/springerreference_225126 · Cited by 406
Chen, R., Sang, L., Jiang, M., Yang, Z., Jia, N., Fu, W., Xie, J., Guan, W., Liang, W., Ni, Z., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.05.003 · Cited by 380
Nosocomial pneumonia in patients with acute respiratory distress syndrome
CHASTRE, J., TROUILLET, J. L., VUAGNAT, A., JOLY-GUILLOU, M. L., CLAVIER, H., DOMBRET, M. C., & GIBERT, C. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.4.9708057 · Cited by 250
Self-citationCytokines IL-1 β, IL-6, and TNF- α Enhance In Vitro Growth of Bacteria
MEDURI, G. U., KANANGAT, S., STEFAN, J., TOLLEY, E., & SCHABERG, D. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.3.9807080 · Cited by 155
Suwa, T., Hogg, J. C., English, D., & Van Eeden, S. F. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.6.h2954 · Cited by 141
Metadata
- Authors
- Chollet-Martin, S., Jourdain, B., Gibert, C., Elbim, C., Chastre, J., & Gougerot-Pocidalo, M. A.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1996-09
- Volume
- 154
- Issue
- 3
- Pages
- 594-601
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2030208822
- Cited by
- 240
- References
- 1
- FWCI
- 20.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chollet-Martin, S., Jourdain, B., Gibert, C., Elbim, C., Chastre, J., & Gougerot-Pocidalo, M. A. (1996). Interactions between neutrophils and cytokines in blood and alveolar spaces during ARDS. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.154.3.8810592
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