Cited by 774Antioxidant Activity and Oxidative StressChronic Obstructive Pulmonary Disease (COPD) ResearchAsthma and respiratory diseases

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

Systemic Oxidative Stress in Asthma, COPD, and Smokers

Rahman, I, Morrison, D, Donaldson, K, MacNee, W·1996·American Journal of Respiratory and Critical Care Medicine

DOI 10.1164/ajrccm.154.4.8887607

Open this paper in CoChat — free account

Abstract

An imbalance between oxidants and antioxidants is proposed in smokers and in patients with airways diseases. We tested this hypothesis by measuring the Trolox equivalent antioxidant capacity (TEAC) of plasma and the levels of products of lipid peroxidation as indices of overall oxidative stress. The plasma TEAC was markedly reduced (0.66 +/- 0.07 mmol/L; mean +/- SEM; n = 11), with increased levels of lipid peroxidation products, in healthy chronic smokers as compared with healthy nonsmokers (1.31 +/- 0.10 mmol/L, n = 14, p < 0.001), an effect that was exaggerated in those who had smoked 1 h before the study. Plasma TEAC was also low in patients presenting with acute exacerbations of chronic obstructive pulmonary disease (COPD) (0.46 +/- 0.10 mmol/L, n = 20, p < 0.001) or asthma (0.61 +/- 0.05 mmol/L, n = 9, p < 0.01) with increases in plasma lipid peroxidation products. There was a negative correlation between superoxide anion release by stimulated neutrophils and plasma antioxidant capacity (r = -0.73, p < 0.001) in patients with acute exacerbations of COPD. The profound decrease in TEAC was associated with a decreased plasma protein sulfhydryl concentrations in acute exacerbations of COPD but not in smokers or in asthmatic subjects. Therefore smoking, acute exacerbations of COPD, and asthma are associated with a marked oxidant/antioxidant imbalance in the blood, associated with evidence of increased oxidative stress. The decreased antioxidant capacity in plasma may result from different mechanisms in these conditions.

Integrity signals

Registry

Crossref · 10.1164/ajrccm.154.4.8887607

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Tissue sulfhydryl groups
Ellman, G. L. (1959) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(59)90090-6 · Cited by 26,824
[49] Determination of carbonyl content in oxidatively modified proteins
Levine, R. L., Garland, D. L., Oliver, C. N., Amici, A., Climent, I., Lenz, A.-G., Ahn, B. W., Shaltiel, S., & Stadtman, E. R. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86141-h · Cited by 5,895
A Novel Method for Measuring Antioxidant Capacity and its Application to Monitoring the Antioxidant Status in Premature Neonates
Miller, N. J., Rice-Evans, C. A., Davies, M. J., Gopinathan, V., & Milner, A. D. (1993) · Clinical Science · doi:10.1042/cs0840407 · Cited by 3,108
A simple fluorometric assay for lipoperoxide in blood plasma
Yagi, K. (1976) · Biochemical Medicine · doi:10.1016/0006-2944(76)90049-1 · Cited by 2,116
Free-Radical Chemistry of Cigarette Smoke and Its Toxicological Implications
CHURCH, D. F., & PRYOR, W. A. (1985) · Environmental Health Perspectives · doi:10.1289/ehp.8564111 · Cited by 1,442
Increase in Circulating Products of Lipid Peroxidation (F2-Isoprostanes) in Smokers — Smoking as a Cause of Oxidative Damage
Morrow, J. D., Frei, B. B., Longmire, A. W., Gaziano, J. M., Lynch, S. M., Shyr, Y., Strauss, W., Oates, J. A., & Roberts, L. J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505043321804 · Cited by 1,340
Oxidants in Cigarette Smoke Radicals, Hydrogen Peroxide, Peroxynitrate, and Peroxynitritea
Pryor, W. A., & Stone, K. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb39148.x · Cited by 1,179
Bronchoalveolar lavage
Mitchell, D., Wells, A. U., Spiro, S. G., & Moller, D. (2012) · CRC Press eBooks · doi:10.1201/b13322-18 · Cited by 828
Normal alveolar epithelial lining fluid contains high levels of glutathione
Cantin, A. M., North, S. L., Hubbard, R. C., & Crystal, R. G. (1987) · Journal of Applied Physiology · doi:10.1152/jappl.1987.63.1.152 · Cited by 797
The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.
Johnston, R. B., Keele, B. B., Misra, H. P., Lehmeyer, J. E., Webb, L., Baehner, R. L., & Rajagopalan, K. V. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108055 · Cited by 704

Show all 30 references

Sorted by citations

Items 101–200 of 773

Respiratory Syncytial Virus Induces Oxidative Stress by Modulating Antioxidant Enzymes
Hosakote, Y. M., Liu, T., Castro, S. M., Garofalo, R. P., & Casola, A. (2009) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0330oc · Cited by 200
Activation of the WNT/β-Catenin Pathway Attenuates Experimental Emphysema
Kneidinger, N., Yildirim, A. Ö., Callegari, J., Takenaka, S., Stein, M. M., Dumitrascu, R., Bohla, A., Bracke, K. R., Morty, R. E., Brusselle, G., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200910-1560oc · Cited by 203
Systemic and pulmonary oxidative stress in idiopathic pulmonary fibrosis
Rahman, I., Skwarska, E., Henry, M., Davis, M. R., O'CONNOR, C. M., FitzGerald, M. X., Greening, A. P., & MacNee, W. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00035-0 · Cited by 195
Determination of patterns of biologically relevant aldehydes in exhaled breath condensate of healthy subjects by liquid chromatography/atmospheric chemical ionization tandem mass spectrometry
Andreoli, R., Manini, P., Corradi, M., Mutti, A., & Niessen, W. M. A. (2003) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.960 · Cited by 193
Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial
Panahi, Y., Ghanei, M., Hajhashemi, A., & Sahebkar, A. (2014) · Journal of Dietary Supplements · doi:10.3109/19390211.2014.952865 · Cited by 192
From muscle disuse to myopathy in COPD: potential contribution of oxidative stress
Couillard, A., & Prefaut, C. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00139904 · Cited by 194
Cardiovascular risk in chronic obstructive pulmonary disease
Maclay, J. D., McAllister, D., & MacNee, W. (2007) · Respirology · doi:10.1111/j.1440-1843.2007.01136.x · Cited by 180
Long-term administration of N-acetylcysteine decreases hydrogen peroxide exhalation in subjects with chronic obstructive pulmonary disease
KASIELSKI, M., & NOWAK, D. (2001) · Respiratory Medicine · doi:10.1053/rmed.2001.1066 · Cited by 179
Exhaled Carbon Monoxide and Nitric Oxide in COPD
Montuschi, P., Kharitonov, S. A., & Barnes, P. J. (2001) · CHEST Journal · doi:10.1378/chest.120.2.496 · Cited by 178
Lipid peroxidation as determined by plasma isoprostanes is related to disease severity in mild asthma
Wood, L. G., Fitzgerald, D. A., Gibson, P. C., Cooper, D. M., & Garg, M. L. (2000) · Lipids · doi:10.1007/s11745-000-0607-x · Cited by 175
State of the Art. Cellular and Molecular Mechanisms of Alveolar Destruction in Emphysema: An Evolutionary Perspective
Tuder, R. M., Yoshida, T., Arap, W., Pasqualini, R., & Petrache, I. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200603-054ms · Cited by 176
Redox theory of aging: implications for health and disease
Go, Y., & Jones, D. P. (2017) · Clinical Science · doi:10.1042/cs20160897 · Cited by 179
Muscle dysfunction in chronic obstructive pulmonary disease: update on causes and biological findings.
Gea, J., Pascual-Guàrdia, S., Casadevall, C., Orozco‐Levi, M., & Barreiro, E. (2015) · PubMed Central · doi:10.3978/j.issn.2072-1439.2015.08.04 · Cited by 185
The Role of Oxidative Stress in the Pathogenesis??of COPD
Rahman, I. (2005) · Treatments in Respiratory Medicine · doi:10.2165/00151829-200504030-00003 · Cited by 171
Viral-mediated Inhibition of Antioxidant Enzymes Contributes to the Pathogenesis of Severe Respiratory Syncytial Virus Bronchiolitis
Hosakote, Y. M., Jantzi, P. D., Esham, D. L., Spratt, H. M., Kurosky, A., Casola, A., & Garofalo, R. P. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201010-1755oc · Cited by 170
Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells
Jorgensen, E. D., Stinson, A., Shan, L., Jin, Y., Gietl, D., & Albino, A. P. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-229 · Cited by 171
Diallylthiosulfinate (Allicin), a Volatile Antimicrobial from Garlic (Allium sativum), Kills Human Lung Pathogenic Bacteria, Including MDR Strains, as a Vapor
Reiter, J., Levina, N., van der Linden, M., Gruhlke, M. C. H., Martin, C., & Slusarenko, A. J. (2017) · Molecules · doi:10.3390/molecules22101711 · Cited by 179
Defensins: Key players or bystanders in infection, injury, and repair in the lung?☆☆☆
van Wetering, S., Sterk, P. J., Rabe, K. F., & Hiemstra, P. S. (1999) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(99)70004-7 · Cited by 164
Fruit and Vegetable Consumption and Mortality
Leenders, M., Sluijs, I., Ros, M. M., Boshuizen, H. C., Siersema, P. D., Ferrari, P., Weikert, C., Tjønneland, A., Olsen, A., Boutron-Ruault, M.-C., et al. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kwt006 · Cited by 163
Increased levels of exhaled carbon monoxide in bronchiectasis: a new marker of oxidative stress
Horváth, I., Loukides, S., Wodehouse, T., Kharitonov, S. A., COLE, P. J., & Barnes, P. J. (1998) · Thorax · doi:10.1136/thx.53.10.867 · Cited by 163
Antioxidants, oxidative stress, and pulmonary function in individuals diagnosed with asthma or COPD
Ochs‐Balcom, H. M., Grant, B. J. B., Muti, P. C., Sempos, C. T., Freudenheim, J. L., Browne, R. W., McCann, S. E., Trevisan, M., Cassano, P. A., Iacoviello, L., et al. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602410 · Cited by 164
The epidemiology and genetics of asthma risk associated with air pollution
Peden, D. B. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.12.003 · Cited by 164
Deacetylases and NF- κ B in Redox Regulation of Cigarette Smoke-Induced Lung Inflammation: Epigenetics in Pathogenesis of COPD
Rajendrasozhan, S., Yang, S., Edirisinghe, I., Yao, H., Adenuga, D., & Rahman, I. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1938 · Cited by 160
Expression of Adhesion Molecules and G Proteins in Circulating Neutrophils in Chronic Obstructive Pulmonary Disease
Noguera, A., Busquets, X., Sauleda, J., Villaverde, J. M. F., MacNee, W., & Agustí, A. G. N. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.5.9712092 · Cited by 159
Antioxidant treatment ameliorates respiratory syncytial virus-induced disease and lung inflammation
Castro, S. M., Guerrero-Plata, A., Suarez-Real, G., Adegboyega, P. A., Colasurdo, G. N., Khan, A. M., Garofalo, R. P., & Casola, A. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200603-319oc · Cited by 160
Peripheral Muscle Alterations in Non-COPD Smokers
de, M. M., Loeb, E., Torres, S. H., Sanctis, J. B. D., Hernández, N., & Tálamo, C. (2008) · CHEST Journal · doi:10.1378/chest.07-1592 · Cited by 154
ROS in the local and systemic pathogenesis of COPD
LANGEN, R. C. J., Korn, S. H., & Wouters, E. F. �. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00316-2 · Cited by 153
The Role of Oxidative Stress in Chronic Obstructive Pulmonary Disease
Bowler, R. P., Barnes, P. J., & Crapo, J. D. (2004) · COPD Journal of Chronic Obstructive Pulmonary Disease · doi:10.1081/copd-200027031 · Cited by 153
Increased nitric oxide metabolites in exhaled breath condensate after exposure to tobacco smoke
Bálint, B., Donnelly, L., Hanazawa, T., Kharitonov, S., & Barnes, P. J. (2001) · Thorax · doi:10.1136/thorax.56.6.456 · Cited by 150
Low-dose theophylline enhances the anti-inflammatory effects of steroids during exacerbations of COPD
Cosío, B. G., Iglesias, A., Rios, A., Noguera, A., Sala, E., Ito, K., Barnes, P. J., & Agustí, A. G. N. (2009) · Thorax · doi:10.1136/thx.2008.103432 · Cited by 154
Effects of Cigarette Smoke in Mice with Different Levels of α1-Proteinase Inhibitor and Sensitivity to Oxidants
Cavarra, E., Bartalesi, B., Lucattelli, M., Fineschi, S., Lunghi, B., Gambelli, F., Ortiz, L. A., Martorana, P. A., & Lungarella, G. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.5.2010032 · Cited by 149
Impacts of antioxidants on hydroxyl radical production from individual and mixed transition metals in a surrogate lung fluid
Charrier, J. G., & Anastasio, C. (2010) · Atmospheric Environment · doi:10.1016/j.atmosenv.2010.12.021 · Cited by 157
Review: Oxidant—antioxidant imbalance in asthma: scientific evidence, epidemiological data and possible therapeutic options
Nadeem, A., Masood, A., & Siddiqui, N. M. (2008) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465808094971 · Cited by 147
Role of epithelial sodium channels in the regulation of lung fluid homeostasis
Matalon, S., Bartoszewski, R., & Collawn, J. F. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00319.2015 · Cited by 147
Cigarette smoke-mediated inflammatory and oxidative responses are strain-dependent in mice
Yao, H., Edirisinghe, I., Rajendrasozhan, S., Yang, S., Caito, S. W., Adenuga, D., & Rahman, I. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00439.2007 · Cited by 145
Animal models of emphysema
Liang, G.-B., & He, Z. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000469 · Cited by 144
Carbon monoxide attenuates aeroallergen-induced inflammation in mice
Chapman, J. T., Otterbein, L. E., Elias, J. A., & Choi, A. M. K. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.281.1.l209 · Cited by 144
Attenuation of oxidant/antioxidant imbalance during treatment of exacerbations of chronic obstructive pulmonary disease
Rahman, I., Skwarska, E., & MacNee, W. (1997) · Thorax · doi:10.1136/thx.52.6.565 · Cited by 142
Comparison between exhaled and sputum oxidative stress biomarkers in chronic airway inflammation
Corradi, M., Pignatti, P., Manini, P., Andreoli, R., Goldoni, M., Poppa, M., Moscato, G., Balbi, B., & Mutti, A. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00002404 · Cited by 142
Exercise-Induced Systemic Effects in Muscle-Wasted Patients with COPD
van Helvoort, H. A. C., Heijdra, Y. F., Thijs, H. M. H., Viña, J., Wanten, G. J. A., & Dekhuijzen, P. N. R. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000228331.13123.53 · Cited by 141
Role of N-acetylcysteine in the management of COPD
Sadowska, A. M., Verbraecken, J. A., Darquennes, K., & Backer, W. D. (2006) · International Journal of COPD · doi:10.2147/copd.2006.1.4.425 · Cited by 140
Pathogenesis of Chronic Obstructive Pulmonary Disease
MacNee, W. (2007) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2007.06.008 · Cited by 136
Heme oxygenase-1 and carbon monoxide in pulmonary medicine
Slebos, D., Ryter, S. W., & Choi, A. M. K. (2003) · Respiratory Research · doi:10.1186/1465-9921-4-7 · Cited by 138
Telomere Length is a Biomarker of Cumulative Oxidative Stress, Biologic Age, and an Independent Predictor of Survival and Therapeutic Treatment Requirement Associated With Smoking Behavior
Babizhayev, M. A., Savel'yeva, E. L., Moskvina, S. N., & Yegorov, Y. E. (2010) · American Journal of Therapeutics · doi:10.1097/mjt.0b013e3181cf8ebb · Cited by 136
Cigarette smoking and glycaemia: the EPIC-Norfolk Study
Sargeant, L. A., Khaw, K., Bingham, S. A., Day, N., Luben, R., Oakes, S., Welch, A. A., & Wareham, N. J. (2001) · International Journal of Epidemiology · doi:10.1093/ije/30.3.547 · Cited by 136
A review of the methodology for assessing in vivo antioxidant capacity
Wood, L. G., Gibson, P. G., & Garg, M. L. (2006) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2604 · Cited by 135
Increased Oxidative Stress and Altered Levels of Antioxidants in Chronic Obstructive Pulmonary Disease
Nadeem, A., Raj, H. G., & Chhabra, S. (2005) · Inflammation · doi:10.1007/s10753-006-8965-3 · Cited by 151
Cigarette Smoke Prevents Apoptosis through Inhibition of Caspase Activation and Induces Necrosis
Wickenden, J. A., Clarke, M. C. H., Rossi, A. G., Rahman, I., Faux, S. P., Donaldson, K., & MacNee, W. (2003) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2002-0235oc · Cited by 132
Hydrogen Peroxide-Induced Apoptosis and Necrosis in Human Lung Fibroblasts: Protective Roles of Glutathione
Teramoto, S., Tetsuji, T., Matsui, H., Ohga, E., Takeshi, M., & Yasuyoshi, O. (1999) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.79.33 · Cited by 132
Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs
Singh, A., Ling, G., Suhasini, A. N., Zhang, P., Yamamoto, M. P., Navas‐Acién, A., Cosgrove, G. P., Tuder, R. M., Kensler, T. W., Watson, W. H., et al. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.10.026 · Cited by 130
Cardiovascular Injury and Repair in Chronic Obstructive Pulmonary Disease
MacNee, W., Maclay, J. D., & McAllister, D. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200807-071th · Cited by 130
Pomegranate juice supplementation in chronic obstructive pulmonary disease: a 5-week randomized, double-blind, placebo-controlled trial
Cerdá, B., Soto, C., Albaladejo, M. D., Martínez, P., Sánchez-Gascón, F., Tomás-Barberán, F. A., & Espı́n, J. C. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602309 · Cited by 130
Evidence of local exercise-induced systemic oxidative stress in chronic obstructive pulmonary disease patients
Couillard, A., Koechlin‐Ramonatxo, C., Cristol, J. P. P., Varray, A. L., & Prefaut, C. (2002) · European Respiratory Journal · doi:10.1183/09031936.02.00014302 · Cited by 129
Antioxidant and Anti-Inflammatory Effects of Resveratrol in Airway Disease
Wood, L. G., Wark, P. A. B., & Garg, M. L. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3064 · Cited by 130
Oxidant metabolism in chronic obstructive pulmonary disease
Boots, A. W., Haenen, G. R. M. M., & Bast, A. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00000403a · Cited by 129
Superoxide Anions Induce the Maturation of Human Dendritic Cells
Kantengwa, S., Jornot, L., Devenoges, C., & Nicod, L. P. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200205-425oc · Cited by 129
Circulating biomarkers of oxidative stress in chronic obstructive pulmonary disease: a systematic review
Zinellu, E., Zinellu, A., Fois, A. G., Carru, C., & Pirina, P. (2016) · Respiratory Research · doi:10.1186/s12931-016-0471-z · Cited by 131
Cigarette Smoke-Induced Reactive Oxygen Species Formation: A Concise Review
Seo, Y., Park, J. M., Kim, J.-H., & Lee, M. (2023) · Antioxidants · doi:10.3390/antiox12091732 · Cited by 126
TOBACCO-RELATED DISEASES
Traber, M. G., van der Vliet, A., Reznick, A. Z., & Cross, C. E. (2000) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(05)70016-2 · Cited by 126
Mitogen-Activated Protein Kinase
Adam, L. P. (1996) · Elsevier eBooks · doi:10.1016/b978-012078160-7/50016-0 · Cited by 131
Oxidative Stress in Critical Care
OLDHAM, K. M., & BOWEN, P. E. (1998) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(98)00230-2 · Cited by 125
Systemic inflammatory biomarkers and co-morbidities of chronic obstructive pulmonary disease
MacNee, W. (2012) · Annals of Medicine · doi:10.3109/07853890.2012.732703 · Cited by 123
Review: Antioxidant therapeutic advances in COPD
Rahman, I. (2008) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465808098224 · Cited by 124
Increased Expression of Heme Oxygenase (HO)-1 in Alveolar Spaces and HO-2 in Alveolar Walls of Smokers
Maestrelli, P., MESSLEMANI, A. H. E., Fina, O. D., Nowicki, Y., Saetta, M. P., Mapp, C. E., & Fabbri, L. M. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.8.2011083 · Cited by 123
Particulate Air Pollution
MacNee, W., & Donaldson, K. (1999) · Air Pollution and Health · doi:10.1016/b978-012352335-8/50105-8 · Cited by 122
Is there any relationship between plasma antioxidant capacity and lung function in smokers and in patients with chronic obstructive pulmonary disease?
Rahman, I. (2000) · Thorax · doi:10.1136/thorax.55.3.189 · Cited by 121
Barriers to inhaled gene therapy of obstructive lung diseases: A review
Kim, N., Duncan, G. A., Hanes, J. S., & Suk, J. S. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.05.031 · Cited by 122
Plasma concentrations of dietary and nondietary antioxidants are low in severe asthma
Misso, N. L. A., Brooks-Wildhaber, J., Ray, S., Vally, H., & Thompson, P. J. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00006705 · Cited by 120
Detrimental Effects of Environmental Tobacco Smoke in Relation to Asthma Severity
COMHAIR, S. A. A., Gaston, B. M., Ricci, K. S., Hammel, J., Dweik, R. A., Teague, W. G., Meyers, D. A., Ampleford, E. J., Bleecker, E. R., Busse, W. W., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018574 · Cited by 120
Pharmacological antioxidant strategies as therapeutic interventions for COPD
Rahman, I. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.11.004 · Cited by 117
Self-citation
Systemic biomarkers in electronic cigarette users: implications for noninvasive assessment of vaping-associated pulmonary injuries
Singh, K. P., Lawyer, G. R., Muthumalage, T., Maremanda, K. P., Khan, N. A., McDonough, S. R., Ye, D., McIntosh, S. E., & Rahman, I. (2019) · ERJ Open Research · doi:10.1183/23120541.00182-2019 · Cited by 123
Asthma and PM10
Donaldson, K., Gilmour, M. I., & MacNee, W. (2000) · Respiratory Research · doi:10.1186/rr5 · Cited by 117
The role for N-acetylcysteine in the management of COPD
Dekhuijzen, P., & van Beurden, W. (2006) · International Journal of COPD · doi:10.2147/copd.2006.1.2.99 · Cited by 119
Sex Differences in Survival of Oxygen-dependent Patients with Chronic Obstructive Pulmonary Disease
Machado, M.-C. L., Krishnan, J. A., Buist, S. A., Bilderback, A. L., Fazolo, G. P., Santarosa, M. G., Queiroga, F., & Vollmer, W. M. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200507-1057oc · Cited by 116
Relation of oxidant-antioxidant imbalance with disease progression in patients with asthma
Husain, Q., Ahmad, A., & Shameem, M. (2012) · Annals of Thoracic Medicine · doi:10.4103/1817-1737.102182 · Cited by 116
Effects of Chronic and Acute Ozone Exposure on Lipid Peroxidation and Antioxidant Capacity in Healthy Young Adults
Chen, C. L., Arjomandi, M., Balmes, J. R., Tager, I. B., & Holland, N. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.10294 · Cited by 113
Cellular senescence in the lung across the age spectrum
Parikh, P., Wicher, S., Khandalavala, K., Pabelick, C. M., Britt, R. D., & Prakash, Y. S. (2019) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00424.2018 · Cited by 112
Genetic Ablation of NADPH Oxidase Enhances Susceptibility to Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice
Yao, H., Edirisinghe, I., Yang, S., Rajendrasozhan, S., Kode, A., Caito, S. W., Adenuga, D., & Rahman, I. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070765 · Cited by 109
Increased DNA damage in patients with chronic obstructive pulmonary disease who had once smoked or been exposed to biomass
Ceylan, E., Koçyiğit, A., Gençer, M., Aksoy, N., & Selek, Ş. (2005) · Respiratory Medicine · doi:10.1016/j.rmed.2005.10.011 · Cited by 109
OXIDATIVE STRESS AND PULMONARY INFLAMMATION: PHARMACOLOGICAL INTERVENTION WITH ANTIOXIDANTS
Morcillo, E. J., Estrela, J. M., & Cortijo, J. (1999) · Pharmacological Research · doi:10.1006/phrs.1999.0549 · Cited by 108
Targeting oxidant-dependent mechanisms for the treatment of COPD and its comorbidities
Bernardo, I., Bozinovski, S., & Vlahos, R. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.08.005 · Cited by 108
Exacerbations of COPD
MacNee, W., & Donaldson, K. (2000) · CHEST Journal · doi:10.1378/chest.117.5_suppl_2.390s · Cited by 105
SIRT1 protects against cigarette smoke-induced lung oxidative stress via a FOXO3-dependent mechanism
Yao, H., Sundar, I. K., Ahmad, T., Lerner, C., Gerloff, J., Friedman, A. E., Phipps, R. P., Sime, P. J., McBurney, M. W., Guarente, L., et al. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00323.2013 · Cited by 104
Self-citation
Airway and systemic oxidant-antioxidant dysregulation in asthma: A possible scenario of oxidants spill over from lung into blood
Nadeem, A., Siddiqui, N. M., Al-Harbi, N. O., & Al-Harbi, M. M. (2014) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2014.06.001 · Cited by 104
Cigarette Smoke Synergistically Enhances Respiratory Mucin Induction by Proinflammatory Stimuli
Baginski, T. K., Dabbagh, K., Satjawatcharaphong, C., & Swinney, D. C. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0259oc · Cited by 104
Changes in exhaled carbon monoxide and nitric oxide levels following allergen challenge in patients with asthma
Paredi, P., Leckie, M. J., Horváth, I., Allegra, L., Kharitonov, S. A., & Barnes, P. J. (1999) · European Respiratory Journal · doi:10.1183/09031936.99.13104899 · Cited by 104
Superoxide Dismutase Mimetics
Salvemini, D., Muscoli, C., Riley, D. P., & Cuzzocrea, S. (2002) · Pulmonary Pharmacology & Therapeutics · doi:10.1006/pupt.2002.0374 · Cited by 105
Structure and function of the respiratory muscles in patients with COPD: impairment or adaptation?: Fig. 1.—
Orozco-Levi, M. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00004607 · Cited by 158
The Implication of Oxidative Stress and AMPK-Nrf2 Antioxidative Signaling in Pneumonia Pathogenesis
Xu, W., Zhao, T., & Xiao, H. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00400 · Cited by 102
Non-invasive biomarkers of oxidative stress: reproducibility and methodological issues
Rahman, I., & Biswas, S. K. (2004) · Redox Report · doi:10.1179/135100004225005219 · Cited by 100
Prognostic significance of plasma D-dimer levels in patients with lung cancer
Taguchi, O., Gabazza, E. C., Yasui, H., Kobayashi, T., Yoshida, M., & Kobayashi, H. (1997) · Thorax · doi:10.1136/thx.52.6.563 · Cited by 100
Protective effects of n ‐acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat
Cuzzocrea, S., Mazzon, E., Dugo, L., Serraino, I., Ciccolo, A., Centorrino, T., Sarro, A. D., & Caputi, A. P. (2001) · The FASEB Journal · doi:10.1096/fj.00-0526hyp · Cited by 100
The Beneficial Effects of Antioxidants in Health and Diseases
Janciauskiene, S. M. (2020) · Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation · doi:10.15326/jcopdf.7.3.2019.0152 · Cited by 100
Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages
Croasdell, A., Thatcher, T. H., Kottmann, R. M., Colas, R. A., Dalli, J., Serhan, C. N., Sime, P. J., & Phipps, R. P. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00125.2015 · Cited by 106
Superoxide dismutase protects against apoptosis and alveolar enlargement induced by ceramide
Petrache, I., Medler, T. R., Richter, A., Kamocki, K., Chukwueke, U. N., Zhen, L., Gu, Y., Adamowicz, J. J., Schweitzer, K. S., Hubbard, W. C., et al. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00448.2007 · Cited by 98
Plasma 3-Nitrotyrosine in Cigarette Smokers
Petruzzelli, S., Puntoni, R., Mimotti, P., Pulerà, N., Baliva, F., Fornai, E., & Giuntini, C. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.156.6.9702075 · Cited by 98
Association of ambient air pollution with hospital outpatient and emergency room visits in Shanghai, China
Cao, J., Li, W., Tan, J., Song, W., Xu, X., Jiang, C., Chen, G., Chen, R., Ma, W., Chen, B., et al. (2009) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2009.07.021 · Cited by 95
Proteinases and oxidants as targets in the treatment of chronic obstructive pulmonary disease.
Owen, C. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200504-029sr · Cited by 96
Induced Sputum 8-Isoprostane Concentrations in Inflammatory Airway Diseases
Wood, L. G., Garg, M. L., Simpson, J. L., Mori, T. A., Croft, K. D., Wark, P. A. B., & Gibson, P. G. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200408-1010oc · Cited by 95
New frontiers in the treatment of comorbid cardiovascular disease in chronic obstructive pulmonary disease
Brassington, K., Selemidis, S., Bozinovski, S., & Vlahos, R. (2019) · Clinical Science · doi:10.1042/cs20180316 · Cited by 97

Authors: Rahman, I., Morrison, D., Donaldson, K., & MacNee, W.
Affiliations: Edinburgh Royal Infirmary (GB)
ORCID: Rahman, I
Morrison, D
MacNee, W
Venue: American Journal of Respiratory and Critical Care Medicine
Publisher: Oxford University Press (OUP)
Published: 1996-10-01
Volume: 154
Issue: 4
Pages: 1055-1060
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/ajrccm.154.4.8887607
OpenAlex: W1984454286
Cited by: 774
References: 30
Citations by year: 2026: 1 · 2025: 9 · 2024: 9 · 2023: 13 · 2022: 15 · 2021: 16 · 2020: 23 · 2019: 18 · 2018: 16 · 2017: 24 · 2016: 20 · 2015: 28 · 2014: 27 · 2013: 25 · 2012: 33
FWCI: 12.55
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Keywords: oxidative stress, asthma, chronic obstructive pulmonary disease, COPD exacerbations, smoking, plasma antioxidant capacity, lipid peroxidation, superoxide, neutrophils, protein sulfhydryl groups, oxidant-antioxidant imbalance
MeSH terms: Adult, Aged, Asthma, Female, Humans, Lipid Peroxides, Lung Diseases, Obstructive, Male, Middle Aged, Smoking, Sulfhydryl Compounds, Superoxides, Lipid Peroxidation, Case-Control Studies, Oxidative Stress

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Systemic Oxidative Stress in Asthma, COPD, and Smokers

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks