The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Dissociation between Airway Inflammation and Airway Hyperresponsiveness in Allergic Asthma
Abstract
In asthma, the acute increment of airway responsiveness caused by exposure to allergen is associated with influx of eosinophils into the airways. The relationship between chronic airway hyperresponsiveness and airway inflammation is unclear, as they do not change consistently following long-term anti-inflammatory treatments. We studied 71 patients with chronic asthma and allergic sensitization to perennial allergens. Airway responsiveness was determined by inhalation of methacholine, and airway inflammation was quantified by induced sputum (n = 28) or bronchoalveolar lavage (n = 43) and bronchial biopsy (n = 20). The relationships between airway responsiveness and the numbers of different inflammatory cells were assessed by multiple regression analysis. No significant correlations were found between the degree of airway responsiveness and the numbers of inflammatory cells in sputum or bronchoalveolar lavage or bronchial biopsy. By contrast, baseline lung function was inversely related to the numbers of eosinophils and directly related to the numbers of macrophages. The eosinophil cationic protein contents of either sputum or bronchoalveolar lavage were significantly correlated with the percentages of eosinophils but not with airway responsiveness. We suggest that other factors (e.g., airway wall remodeling or autonomic dysfunction) may be responsible for most of the interindividual variability of airway responsiveness in asthma.
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Cites
Lung volumes and forced ventilatory flows
Quanjer, P. H., Tammeling, G. J., Cotes, J. E., Pedersen, O. F., Peslin, R., & Yernault, J.-C. (1993) · European Respiratory Journal · doi:10.1183/09041950.005s1693 · Cited by 5,318
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Wardlaw, A. J., Dunnette, S., Gleich, G. J., Collins, J. V., & Kay, A. B. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/137.1.62 · Cited by 907
Bradley, B. L., Azzawi, M., Jacobson, M., Assoufi, B., Collins, J. V., Irani, A.-M. A., Schwartz, L. B., Durham, S. R., Jeffery, P. K., & Kay, A. B. (1991) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(91)90160-p · Cited by 665
Effect of an Inhaled Corticosteroid on Airway Inflammation and Symptoms in Asthma
Djukanović, R., Wilson, J. W., Britten, K. M., Wilson, S. J., Walls, A. F., Roche, W. R., Howarth, P. H., & Holgate, S. T. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/145.3.669 · Cited by 639
Jeffery, P. K., Godfrey, R. W., Ädelroth, E., Nelson, F., Rogers, A., & Johansson, S.-A. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/145.4_pt_1.890 · Cited by 535
Skloot, G., Permutt, S., & Togias, A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118296 · Cited by 481
Bronchoalveolar Cell Profiles of Asthmatic and Nonasthmatic Subjects
Kirby, J. G., Hargreave, F. E., Gleich, G. J., & O'Byrne, P. M. (1987) · American Review of Respiratory Disease · doi:10.1164/ajrccm/136.2.379 · Cited by 471
Walker, C., Kaegi, M. K., Braun, P., & Blaser, K. (1991) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(91)90251-i · Cited by 464
Cited by
Reddel, H. K., Taylor, D. R., Bateman, E. D., Boulet, L.-P., Boushey, H. A., Busse, W. W., Casale, T. B., Chanez, P., Enright, P. L., Gibson, P. G., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200801-060st · Cited by 1,918
Asthma: From Bronchoconstriction to Airways Inflammation and Remodeling
BOUSQUET, J., JEFFERY, P. K., BUSSE, W. W., JOHNSON, M., & VIGNOLA, A. M. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.5.9903102 · Cited by 1,702
Mouse Monocyte-Derived Chemokine Is Involved in Airway Hyperreactivity and Lung Inflammation
Gonzalo, J.-A., Pan, Y., Lloyd, C. M., Jia, G.-Q., Yu, G., Dussault, B., Powers, C. A., Proudfoot, A. E. I., Coyle, A. J., Gearing, D., et al. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.1.403 · Cited by 248
Nasal involvement in allergic asthma
Braunstahl, G. ‐., & Fokkens, W. (2003) · Allergy · doi:10.1046/j.0105-4538.2003.00354.x · Cited by 102
New insights into the role of the mast cell in asthma.
Brightling, C. E., Bradding, P., Pavord, I. D., & Wardlaw, A. J. (2003) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2003.01636.x · Cited by 97
Metadata
- Authors
- CRIMI, E., SPANEVELLO, A., NERI, M., IND, P. W., ROSSI, G. A., & BRUSASCO, V.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-01-01
- Volume
- 157
- Issue
- 1
- Pages
- 4-9
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2049472311
- Cited by
- 508
- References
- 28
- FWCI
- 27.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- CRIMI, E., SPANEVELLO, A., NERI, M., IND, P. W., ROSSI, G. A., & BRUSASCO, V. (1998). Dissociation between Airway Inflammation and Airway Hyperresponsiveness in Allergic Asthma. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.157.1.9703002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
