Mouse Monocyte-Derived Chemokine Is Involved in Airway Hyperreactivity and Lung Inflammation
Abstract
The cloning, expression, and function of the murine (m) homologue of human (h) monocyte-derived chemokine (MDC) is reported here. Like hMDC, mMDC is able to elicit the chemotactic migration in vitro of activated lymphocytes and monocytes. Among activated lymphocytes, Th2 cells were induced to migrate most efficiently. mMDC mRNA and protein expression is modulated during the course of an allergic reaction in the lung. Neutralization of mMDC with specific Abs in a model of lung inflammation resulted in prevention of airway hyperreactivity and significant reduction of eosinophils in the lung interstitium but not in the airway lumen. These data suggest that mMDC is essential in the transit/retention of leukocytes in the lung tissue rather than in their extravasation from the blood vessel or during their transepithelial migration into the airways. These results also highlight the relevance of factors, such as mMDC, that regulate the migration and accumulation of leukocytes within the tissue during the development of the key physiological endpoint of asthma, airway hyperreactivity.
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The chemokines CCL17, CCL22 and their receptor CCR4 are each important in the development of allergic inflammation.
“The chemokines CCL17, CCL22 and their receptor CCR4, are each important in the development of allergic inflammation38–40.”
From The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation (2010) · cites this paper as [38]
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Chang, H.-C., Sehra, S., Goswami, R., Yao, W., Yu, Q., Stritesky, G. L., Jabeen, R., McKinley, C., Ahyi, A.-N., Han, L., et al. (2010) · Nature Immunology · doi:10.1038/ni.1867 · Cited by 577 · see citing works
Kawasaki, S., Takizawa, H., Yoneyama, H., Nakayama, T., Fujisawa, R., Izumizaki, M., Imai, T., Yoshie, O., Homma, I., Yamamoto, K., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.2055 · Cited by 261 · see citing works
Chemokine receptors in allergic diseases
Castan, L., Magnan, A., & Bouchaud, G. (2017) · Allergy · doi:10.1111/all.13089 · Cited by 80 · see citing works
- Authors
- Gonzalo, J.-A., Pan, Y., Lloyd, C. M., Jia, G.-Q., Yu, G., Dussault, B., Powers, C. A., Proudfoot, A. E. I., Coyle, A. J., Gearing, D., & Gutierrez-Ramos, J.-C.
- Affiliations
- Millennium Pharmaceuticals, Inc. , Cambridge, MA 02139
- Millennium Biotherapeutics, Inc. , Cambridge, MA 02139
- Takeda Oncology (United States) (US)
- Merck Serono S.A. (Switzerland) (CH)
- Corresponding author
- Dussault, Barry
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-07-01
- Volume
- 163
- Issue
- 1
- Pages
- 403-411
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2154772518
- Cited by
- 248
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 6 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 3 · 2014: 6 · 2013: 4 · 2012: 4
- FWCI
- 15.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (087618)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- CCL22, airway hyperresponsiveness, lung inflammation, asthma, Th2 cells, eosinophils, leukocyte migration, allergic airway inflammation, chemokine neutralization
- MeSH terms
- Amino Acid Sequence, Animals, Calcium, Cell Line, Chemotaxis, Leukocyte, Desensitization, Immunologic, Humans, Immune Sera, Inflammation, Lung, Mice, Inbred C57BL, Molecular Sequence Data, Recombinant Proteins, Time Factors, Transfection, Bronchial Hyperreactivity, Receptors, Chemokine, Chemokines, CC, Mice, Receptors, CCR4, Chemokine CCL22
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