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A Quantification of the Lung Surface Area in Emphysema Using Computed Tomography
Abstract
Quantitative analysis of computed tomography (CT) has been combined with a stereologically based histologic analysis of lung structure to assess regional lung inflation and the structural features of the lung parenchyma. In this study, CT measurements of lung inflation were compared with histologic estimates of surface area in order to develop prediction equations that allow lung surface to volume ratio and surface area to be predicted from an analysis of the CT scan. The results show that mild emphysema is associated with an increase in lung volume and a reduction in surface to volume ratio, whereas surface area and tissue weight were only decreased in severe disease. The CT predicted surface to volume ratio correlated with histology, and both predicted and measured surface areas correlated with the diffusing capacity. We conclude that this CT analysis can be used to monitor the progression of emphysematous lung destruction in individual patients, and to assess the impact of both surgical and medical treatments for emphysema.
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Cited by
The Microbiome and the Respiratory Tract
Dickson, R. P., Erb-Downward, J. R., Martinez, F. J., & Huffnagle, G. B. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105238 · Cited by 953
Computed Tomographic Measurements of Airway Dimensions and Emphysema in Smokers
NAKANO, Y., MURO, S., SAKAI, H., HIRAI, T., CHIN, K., TSUKINO, M., NISHIMURA, K., ITOH, H., PARÉ, P. D., HOGG, J. C., et al. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.3.9907120 · Cited by 695
Self-citationLynch, D. A., Austin, J. H. M., Hogg, J. C., Grenier, P. A., Kauczor, H.-U., Bankier, A. A., Barr, R. G., Colby, T. V., Galvin, J. R., Gevenois, P. A., et al. (2015) · Radiology · doi:10.1148/radiol.2015141579 · Cited by 658
Self-citationThe role of the microbiome in exacerbations of chronic lung diseases
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Schroeder, J. D., McKenzie, A. S., Zach, J. A., Wilson, C. G., Curran-Everett, D., Stinson, D. S., Newell, J. D., & Lynch, D. A. (2013) · American Journal of Roentgenology · doi:10.2214/ajr.12.10102 · Cited by 334
Metadata
- Authors
- COXSON, H. O., ROGERS, R. M., WHITTALL, K. P., D'YACHKOVA, Y., PARÉ, P. D., SCIURBA, F. C., & HOGG, J. C.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-03-01
- Volume
- 159
- Issue
- 3
- Pages
- 851-856
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2116856128
- Cited by
- 369
- References
- 0
- FWCI
- 10.38
- Type
- journal article
- Language
- en
- Open access
- closed
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- COXSON, H. O., ROGERS, R. M., WHITTALL, K. P., D'YACHKOVA, Y., PARÉ, P. D., SCIURBA, F. C., & HOGG, J. C. (1999). A Quantification of the Lung Surface Area in Emphysema Using Computed Tomography. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.159.3.9805067
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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