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Cited by 629

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Acute Respiratory Failure in Patients with Severe Community-acquired Pneumonia: A Prospective Randomized Evaluation of Noninvasive Ventilation

CONFALONIERI, MARCO, POTENA, ALFREDO, CARBONE, GIORGIO, PORTA, ROSSANA DELLA, TOLLEY, ELIZABETH A., UMBERTO MEDURI, G.·1999·American Journal of Respiratory and Critical Care Medicine
DOI 10.1164/ajrccm.160.5.9903015
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Abstract

In uncontrolled studies, noninvasive positive pressure ventilation (NPPV) was found useful in avoiding endotracheal intubation in patients with acute respiratory failure (ARF) caused by severe community-acquired pneumonia (CAP). We conducted a prospective, randomized study comparing standard treatment plus NPPV delivered through a face mask to standard treatment alone in patients with severe CAP and ARF. Patients fitting the American Thoracic Society criteria for severe CAP were included in presence of ARF (refractory hypoxemia and/or hypercapnia with acidosis). Exclusion criteria were: severe hemodynamic instability, requirement for emergent cardiopulmonary resuscitation, home mechanical ventilation or oxygen long-term supplementation, concomitant severe disease with a low expectation of life, inability to expectorate or contraindications to the use of the mask. Fifty-six consecutive patients (28 in each arm) were enrolled, and the two groups were similar at study entry. The use of NPPV was well tolerated, safe, and associated with a significant reduction in respiratory rate, need for endotracheal intubation (21% versus 50%; p = 0.03), and duration of intensive care unit (ICU) stay (1.8 +/- 0.7 d versus 6 +/- 1.8 d; p = 0.04). The two groups had a similar intensity of nursing care workload, time interval from study entry to endotracheal intubation, duration of hospitalization, and hospital mortality. Among patients with chronic obstructive pulmonary disease (COPD), those randomized to NPPV had a lower intensity of nursing care workload (p = 0.04) and improved 2-mo survival (88.9% versus 37.5%; p = 0.05). We conclude that in selected patients with ARF caused by severe CAP, NPPV was associated with a significant reduction in the rate of endotracheal intubation and duration of ICU stay. A 2-mo survival advantage was seen in patients with COPD.

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Metadata

Authors
CONFALONIERI, M., POTENA, A., CARBONE, G., PORTA, R. D., TOLLEY, E. A., & UMBERTO MEDURI, G.
Venue
American Journal of Respiratory and Critical Care Medicine
Publisher
Oxford University Press (OUP)
Published
1999-11-01
Volume
160
Issue
5
Pages
1585-1591
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
DOI
10.1164/ajrccm.160.5.9903015
OpenAlex
W2104701045
Cited by
629
References
21
FWCI
21.06
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Acute Respiratory Failure in Patients with Severe Community-acquired Pneumonia: A Prospective Randomized Evaluation of Noninvasive Ventilation. https://app.cochat.ai/papers/10.1164/ajrccm.160.5.9903015
The paper
CONFALONIERI, M., POTENA, A., CARBONE, G., PORTA, R. D., TOLLEY, E. A., & UMBERTO MEDURI, G. (1999). Acute Respiratory Failure in Patients with Severe Community-acquired Pneumonia: A Prospective Randomized Evaluation of Noninvasive Ventilation. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.160.5.9903015

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.