The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Noninvasive Ventilation with Helium–Oxygen in Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Abstract
The use of helium-oxygen (HeO(2)) was tested in combination with noninvasive ventilation (NIV) in 10 patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Effort to breathe as assessed by the respiratory muscle pressure-time index (PTI), work of breathing (WOB), and gas exchange were the main endpoints. Results of NIV-HeO(2) were compared with those obtained with standard NIV (AirO(2)), at two levels of pressure-support ventilation (PSV), 9 +/- 2 cm H(2)O and 18 +/- 3 cm H(2)O. Significant reductions in PTI were observed between HeO(2) and AirO(2) at both the low PSV level (n = 9; 160 +/- 58 versus 198 +/- 78 cm H(2)O/s/ min; p < 0.05) and the high PSV level (n = 10; 100 +/- 45 versus 150 +/- 82 cm H(2)O/s/min; p < 0.01). WOB also differed significantly between HeO(2) and AirO(2) (7.8 +/- 4.1 versus 10.9 +/- 6.1 J/min at the low PSV level, p < 0.05; and 5.7 +/- 3.3 versus 9.2 +/- 5. J/min, p < 0.01 at the high PSV level). HeO(2) reduced Pa(CO(2)) at both the low PSV level (61 +/- 13 versus 64 +/- 15 mm Hg; p < 0.05) and the high PSV level (56 +/- 13 versus 58 +/- 14 mm Hg; p < 0.05), without significantly changing breathing pattern or oxygenation. We conclude that use of HeO(2) during NIV markedly enhances the ability of NIV to reduce patient effort and to improve gas exchange.
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Citations
Cites
Le Gall, J.-R. (1993) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.270.24.2957 · Cited by 7,773
Cited by
Ram, F. S., Picot, J., Lightowler, J., & Wedzicha, J. A. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004104.pub3 · Cited by 552
Jaber, S., Jung, B., Corne, P., Sebbane, M., Muller, L., Chanques, G., Verzilli, D., Jonquet, O., Eledjam, J.-J., & Lefrant, J.-Y. (2010) · Intensive Care Medicine · doi:10.1007/s00134-009-1717-8 · Cited by 508
Self-citationBTS/ICS guideline for the ventilatory management of acute hypercapnic respiratory failure in adults
Davidson, A. C., Banham, S., Elliott, M., Kennedy, D., Gelder, C., Glossop, A., Church, A. C., Creagh-Brown, B., Dodd, J. W., Felton, T., et al. (2016) · Thorax · doi:10.1136/thoraxjnl-2015-208209 · Cited by 426
Osadnik, C. R., Tee, V. S., Carson-Chahhoud, K. V., Picot, J., Wedzicha, J. A., & Smith, B. J. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004104.pub4 · Cited by 422
Physiologic Effects of Noninvasive Ventilation during Acute Lung Injury
L'Her, E., Deye, N., Lellouche, F., Taille, S., Demoule, A., Fraticelli, A., Mancebo, J., & Brochard, L. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200402-226oc · Cited by 395
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Metadata
- Authors
- JABER, S., FODIL, R., CARLUCCI, A., BOUSSARSAR, M., PIGEOT, J., LEMAIRE, F., HARF, A., LOFASO, F., ISABEY, D., & BROCHARD, L.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-04-01
- Volume
- 161
- Issue
- 4
- Pages
- 1191-1200
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2163673929
- Cited by
- 164
- References
- 1
- FWCI
- 13.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Noninvasive Ventilation with Helium–Oxygen in Acute Exacerbations of Chronic Obstructive Pulmonary Disease. https://app.cochat.ai/papers/10.1164/ajrccm.161.4.9904065
- The paper
- JABER, S., FODIL, R., CARLUCCI, A., BOUSSARSAR, M., PIGEOT, J., LEMAIRE, F., HARF, A., LOFASO, F., ISABEY, D., & BROCHARD, L. (2000). Noninvasive Ventilation with Helium–Oxygen in Acute Exacerbations of Chronic Obstructive Pulmonary Disease. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.161.4.9904065
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
