Asthma: From Bronchoconstriction to Airways Inflammation and Remodeling

Cessation of Long-term Treatment with Inhaled Corticosteroid (Budesonide) in Children with Asthma Results in Deterioration

Waalkens, H. J., Essen-Zandvliet, E. E. V., Hughes, M. D., Gerritsen, J., Duiverman, E. J., Knol, K., Kerrebijn, K. F., & The Dutch CNSLD Study Group (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/148.5.1252 · Cited by 203

Effect of Nitrogen Dioxide on Synthesis of Inflammatory Cytokines Expressed by Human Bronchial Epithelial Cells In Vitro

Devalia, J. L., Campbell, A., Sapsford, R. J., Rusznák, C., Quint, D. J., Godard, P., Bousquet, J., & Davies, R. J. (1993) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/9.3.271 · Cited by 202

Detection of GM-CSF in Asthmatic Bronchial Epithelium and Decrease by Inhaled Corticosteroids

Sousa, A. R., Poston, R. N., Lane, S. J., Nakhosteen, J. A., & Lee, T. H. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/147.6_pt_1.1557 · Cited by 201

Hyperplasia of bronchial muscle in asthma

Heard, B. E., & Hossain, S. (1973) · The Journal of Pathology · doi:10.1002/path.1711100406 · Cited by 199

A research method to induce and examine a mild exacerbation of asthma by withdrawal of inhaled corticosteroid

Gibson, P. G., Wong, B., HEPPERLE, M. J. E., Kline, P. A., Girgis-Gabardo, A., Guyatt, G. H., Dolovich, J., Denburg, J. A., Ramsdale, E. H., & Hargreave, F. E. (1992) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1992.tb00161.x · Cited by 197

Indirect evidence of bronchial inflammation assessed by titration of inflammatory mediators in BAL fluid of patients with asthma

Bousquet, J., Chanez, P., Lacoste, J. Y., Enander, I., Venge, P., PETERSON, C., Ahlstedt, S., Michel, F. B., & Godard, P. (1991) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(91)90159-l · Cited by 196

Asthma in the Elderly: A Comparison Between Patients with Recently Acquired and Long-standing Disease

Braman, S. S., Kaemmerlen, J. T., & Davis, S. M. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/143.2.336 · Cited by 196

Cleavage of Type I Procollagen by Human Mast Cell Chymase Initiates Collagen Fibril Formation and Generates a Unique Carboxyl-terminal Propeptide

Kofford, M. W., Schwartz, L. B., Schechter, N. M., Yager, D. R., Diegelmann, R. F., & Graham, M. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.11.7127 · Cited by 191

Number and activity of inflammatory cells in bronchoalveolar lavage fluid in asthma and their relation to airway responsiveness.

Kelly, C., Ward, C., Stenton, C., Bird, G., Hendrick, D. J., & Walters, E. H. (1988) · Thorax · doi:10.1136/thx.43.9.684 · Cited by 190

Airway Responsiveness and Bronchial-Wall Thickness in Asthma With or Without Fixed Airflow Obstruction

Boulet, L., Bélanger, M., & Carrier, G. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.3.7663797 · Cited by 189

Mast cells in bronchoalveolar lumen of patients with bronchial asthma.

Tomioka, M., Shiro, I. D. A., Shindoh, Y., Ishihara, T., & Takishima, T. (1984) · PubMed · doi:10.1164/arrd.1984.129.6.1000 · Cited by 188

INCREASED NUMBERS OF DENDRITIC CELLS IN THE BRONCHIAL MUCOSA OF ATOPIC ASTHMATIC PATIENTS: DOWNREGULATION BY INHALED CORTICOSTEROIDS

Möller, G. M., Overbeek, S. E., van Helden-Meeuwsen, C. G., van Haarst, J. M. W., Prens, E. P., Mulder, P. G. H., Postma, D. S., & Hoogsteden, H. C. (1996) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1996.tb00571.x · Cited by 187

Activated memory T helper cells in bronchoalveolar lavage fluid from patients with atopic asthma: relation to asthma symptoms, lung function, and bronchial responsiveness.

Robinson, D. S., Bentley, A. M., Hartnell, A., Kay, A. B., & Durham, S. R. (1993) · Thorax · doi:10.1136/thx.48.1.26 · Cited by 187

Expression and localization of tumor necrosis factor-alpha and its mRNA in idiopathic pulmonary fibrosis.

Piguet, P. F., Ribaux, C., Karpuz, V., Grau, G. E., & Kapançi, Y. (1993) · PubMed Central · Cited by 187

Inflammation and Airway Function in Asthma: What You See Is Not Necessarily What You Get

Haley, K. J., & Drazen, J. M. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.1.ed-19 · Cited by 184

Expression of endothelial and leukocyte adhesion molecules intercellular adhesion molecule-1, E-selectin, and vascular cell adhesion molecule-1 in the bronchial mucosa in steady-state and allergen-induced asthma

Bentley, A. M., Durham, S. R., Robinson, D. S., Menz, G., Storz, C., Cromwell, O., KAY, A., & Wardlaw, A. J. (1993) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(93)90064-m · Cited by 182

Comparison of fluticasone propionate with beclomethasone dipropionate in moderate to severe asthma treated for one year. International Study Group.

Fabbri, L. M., Burge, P. S., Croonenborgh, L., Warlies, F., Weeke, B., Ciaccia, A., & Parker, C. (1993) · Thorax · doi:10.1136/thx.48.8.817 · Cited by 182

A twelve month comparison of salmeterol with salbutamol in asthmatic patients. European Study Group

Britton, M., Earnshaw, J., & Palmer, J. (1992) · European Respiratory Journal · doi:10.1183/09031936.93.05091062 · Cited by 181

Fluticasone Propionate Reduces Oral Prednisone Use While It Improves Asthma Control and Quality of Life

Noonan, M. J., Chervinsky, P., Busse, W. W., Weisberg, S. C., Pinnas, J. L., Boisblanc, B. P. D., Boltansky, H., Pearlman, D. S., Repsher, L. H., & Kellerman, D. J. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.5.7582278 · Cited by 181

Spectrum of Prostanoid Release after Bronchoalveolar Allergen Challenge in Atopic Asthmatics and in Control Groups: An Alteration in the Ratio of Bronchoconstrictive to Bronchoprotective Mediators

Wenzel, S. E., Westcott, J. Y., Smith, H. R., & Larsen, G. L. (1989) · American Review of Respiratory Disease · doi:10.1164/ajrccm/139.2.450 · Cited by 180

Functional assessment of alveolar macrophages: comparison of cells from asthmatics and normal subjects

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Bronchial epithelial cell-cytokine interactions in airway inflammation.

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Macrophage inflammatory protein-1 alpha expression in interstitial lung disease.

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Tropical Pulmonary Eosinophilia

Ottesen, E. A., & Nutman, T. B. (1992) · Annual Review of Medicine · doi:10.1146/annurev.me.43.020192.002221 · Cited by 176

Airflow Limitation in Chronic Bronchitis Is Associated With T-Lymphocyte and Macrophage Infiltration of the Bronchial Mucosa

Stefano, A. D., Turato, G., Maestrelli, P., Mapp, C. E., Ruggieri, M. P., Roggeri, A., Boschetto, P., Fabbri, L. M., & Saetta, M. P. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.2.8564109 · Cited by 175

Chest Radiography and High Resolution Computed Tomography of the Lungs in Asthma

Paganin, F., Trussard, V., Senéterre, E., Chanez, P., Giron, J., Godard, P., Senac, J. P., Michel, F. B., & Bousquet, J. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.4.1084 · Cited by 175

Airway obstruction in asthmatic and healthy individuals: inspiratory and expiratory thin-section CT findings.

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Adult Patients May Outgrow Their Asthma: A 25-Year Follow-Up Study

Panhuysen, C. I. M., Vonk, J. M., Koëter, G. H., Schouten, J. P., van Altena, R., Bleecker, E. R., & Postma, D. S. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.4.9105065 · Cited by 175

T Lymphocytes and Activated Eosinophils in Airway Mucosa in Fatal Asthma and Cystic Fibrosis

Azzawi, M., Johnston, P., Majumdar, S., Kay, A. B., & Jeffery, P. K. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/145.6.1477 · Cited by 173

Formation of endothelin by cultured airway epithelial cells

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Airway Mucosal Inflammation in Occupational Asthma Induced by Toluene Diisocyanate

Saetta, M. P., Stefano, A. D., Maestrelli, P., Marzo, N. D., Milani, G., Pivirotto, F., Mapp, C. E., & Fabbri, L. M. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/145.1.160 · Cited by 168

Inhibition of programmed eosinophil death: a key pathogenic event for eosinophilia?

Simon, H., & Blaser, K. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80086-7 · Cited by 167

Tissue eosinophilia and eosinophil degranulation in syndromes associated with fibrosis.

Noguchi, H., Kephart, G. M., Colby, T. V., & Gleich, G. J. (1992) · PubMed Central · Cited by 165

Fluticasone propionate aerosol for the treatment of adults with mild to moderate asthma

Chervinsky, P., van As, A., Bronsky, E. A., Dockhorn, R. J., Noonan, M. J., Force, C. L., & Pleskow, W. W. (1994) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(94)90174-0 · Cited by 164

Effects of montelukast (MK-0476); a potent cysteinyl leukotriene receptor antagonist, on bronchodilation in asthmatic subjects treated with and without inhaled corticosteroids

Reiss, T. F., Sorkness, C. A., Stricker, W., Botto, A., Busse, W. W., Kundu, S., & Zhang, J. (1997) · Thorax · doi:10.1136/thx.52.1.45 · Cited by 163

Human eotaxin represents a potent activator of the respiratory burst of human eosinophils

Elsner, J., Höchstetter, R., Kimmig, D., & Kapp, A. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260837 · Cited by 163

Effect of inhaled corticosteroids on episodes of wheezing associated with viral infection in school age children: randomised double blind placebo controlled trial

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Human blood basophils produce interleukin-13 in response to IgE- receptor-dependent and -independent activation

Ochensberger, B., Daepp, G., Rihs, S., & Dahinden, C. A. (1996) · Blood · doi:10.1182/blood.v88.8.3028.bloodjournal8883028 · Cited by 162

Assembly of extracellular matrix

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Airway smooth muscle cell culture: application to studies of airway wall remodelling and phenotype plasticity in asthma

Hirst, S. (1996) · European Respiratory Journal · doi:10.1183/09031936.96.09040808 · Cited by 161

Bronchial Mucosal Expression of the Genes Encoding Chemokines RANTES and MCP-3 in Symptomatic Atopic and Nonatopic Asthmatics: Relationship to the Eosinophil-Active Cytokines Interleukin (IL)-5, Granulocyte Macrophage-Colony-Stimulating Factor, and IL-3

Humbert, M. J. C., Ying, S., Corrigan, C. J., Menz, G., Barkans, J. R., Pfister, R., Meng, Q., Damme, J. V., Opdenakker, G., Durham, S. R., et al. (1997) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.16.1.8998072 · Cited by 159

Glucocorticosteroid inhibition of cytokine production: Relevance to antiallergic actions

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Bronchial hyperreactivity

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Eicosanoids in Bronchoalveolar Lavage Fluid of Aspirin-Intolerant Patients with Asthma After Aspirin Challenge

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The Effect of Inhaled Leukotriene D4 and Methacholine on Sputum Cell Differentials in Asthma

Diamant, Z., Hiltermann, T. J. N., van Rensen, E. L., Callenbach, P. M. C., Veselic‐Charvat, M., van der Veen, H., Sont, J. K., & Sterk, P. J. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.4.9105062 · Cited by 157

Detection of alveolar macrophage-derived IL-1 beta in asthma. Inhibition with corticosteroids

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Therapeutic uses of heparin beyond its traditional role as an anticoagulant

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Effects of epidermal growth factor, fibroblast growth factor, and transforming growth factor-beta on corneal cell chemotaxis.

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Increased Levels of CD34+ Hemopoietic Progenitor Cells in Atopic Subjects

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Effect of Eight Weeks of Treatment with Salmeterol on Bronchoalveolar Lavage Inflammatory Indices in Asthmatics

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Altered Adhesion Molecule Expression and Endothelial Cell Activation Accompany the Recruitment of Human Granulocytes to the Lung after Segmental Antigen Challenge

Georas, S. N., Liu, M. C., Newman, W., Beall, L. D., Stealey, B. A., & Bochner, B. S. (1992) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/7.3.261 · Cited by 153

Causes of Death and Pathologic Findings in 304 Cases of Bronchial Asthma

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Expression of RANTES mRNA and Protein in Airways of Patients With Mild Asthma

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Elevated Bronchoalveolar Lavage Fluid Histamine Levels in Allergic Asthmatics Are Associated with Increased Airway Obstruction

Jarjour, N. N., Calhoun, W. J., Schwartz, L. B., & Busse, W. W. (1991) · American Review of Respiratory Disease · doi:10.1164/ajrccm/144.1.83 · Cited by 150

Eosinophil hematopoietins antagonize the programmed cell death of eosinophils. Cytokine and glucocorticoid effects on eosinophils maintained by endothelial cell-conditioned medium.

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Continuity of airway goblet cells and intraluminal mucus in the airways of patients with bronchial asthma

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Identification of IgE-Bearing Cells in the Late-Phase Response to Antigen in the Lung as Basophils

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CD34+/Interleukin-5R α Messenger RNA+ Cells in the Bronchial Mucosa in Asthma: Potential Airway Eosinophil Progenitors

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Reduction of budesonide after a year of increased use: A randomized controlled trial to evaluate whether improvements in airway responsiveness and clinical asthma are maintained

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Peripheral Blood CD4 But Not CD8 t-Lymphocytes in Patients with Exacerbation of Asthma Transcribe and Translate Messenger RNA Encoding Cytokines Which Prolong Eosinophil Survival in the Context of a Th2-Type Pattern: Effect of Glucocorticoid Therapy

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Early Identification of Interleukin-16 (Lymphocyte Chemoattractant Factor) and Macrophage Inflammatory Protein 1 α (MIP1 α) in Bronchoalveolar Lavage Fluid of Antigen-Challenged Asthmatics

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Bronchial Responsiveness to Distilled Water and Methacholine and Its Relationship to Inflammation and Remodeling of the Airways in Asthma

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Matrix metalloproteases and lung disease.

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Inhaled Nitric Oxide. A Bronchodilator in Mild Asthmatics With Methacholine-Induced Bronchospasm

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Computerized Tomography in the Evaluation of Allergic Bronchopulmonary Aspergillosis

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Abnormalities in pathways of alveolar fibrin turnover among patients with interstitial lung disease.

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Inflammatory Cell Populations in Bronchial Biopsies From Aspirin-Sensitive Asthmatic Subjects

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Histochemical Characteristics and Degranulation of Mast Cells in Epithelium and Lamina Propria of Bronchial Biopsies from Asthmatic and Normal Subjects

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Childhood Asthma and Adult Lung Function

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Untitled work

(1996) · PubMed · Cited by 137

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CD40 and epithelial cells: across the great divide

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Heparin Inhibits the Immediate Response to Antigen in the Skin and Lungs of Allergic Subjects

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