The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Evidence of Airway Inflammation and Remodeling in Ski Athletes with and without Bronchial Hyperresponsiveness to Methacholine
Abstract
Asthma-like symptoms, methacholine hyperresponsiveness, and use of asthma medication are prevalent in elite cross-country skiers. We quantitated mucosal inflammatory cell infiltration and tenascin expression in the subepithelial basement membrane in endobronchial biopsy specimens of the proximal airways from 40 elite, competitive skiers (mean: 17.5; range: 16 to 20 yr) without a diagnosis of asthma, in 12 subjects with mild asthma, and in 12 healthy controls, through immunohistochemistry and indirect immunofluorescence, respectively. All of the subjects were nonsmokers. T-lymphocyte, macrophage, and eosinophil counts were, respectively, greater by 43-fold (p < 0.001), 26-fold (p < 0.001), and twofold (p < 0.001) in skiers, and by 70-fold (p < 0.001), 63-fold (p < 0.001), and eightfold (p < 0.001) in asthmatic subjects than in controls. In skiers, neutrophil counts were more than twofold greater than in asthmatic subjects, and mast cell counts were not significantly different than in controls. Tenascin expression (as measured through the thickness of the tenascin-specific immunoreactivity band in the basement membrane) was increased in skiers (median: 6.7 microm; interquartile range [IQR]: 5.3 to 8.5 microm, p < 0.001) and asthmatic subjects (mean: 8.8 microm; IQR: 7.2 to 10.8 microm, p < 0. 001) compared with controls (mean: 0.8 microm; IQR: 0 to 3.1 microm) and did not correlate with inflammatory cell counts. Inflammatory changes were present irrespective of asthmalike symptoms, hyperresponsiveness, or atopy. Prolonged repeated exposure of the airways to inadequately conditioned air may induce inflammation and remodeling in competitive skiers.
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Cites
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Self-citationBradley, B. L., Azzawi, M., Jacobson, M., Assoufi, B., Collins, J. V., Irani, A.-M. A., Schwartz, L. B., Durham, S. R., Jeffery, P. K., & Kay, A. B. (1991) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(91)90160-p · Cited by 665
Induction of tenascin in healing wounds
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Airway Mucosal Inflammation Even in Patients with Newly Diagnosed Asthma
Laitinen, L. A., Laitinen, A., & Haahtela, T. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/147.3.697 · Cited by 524
Self-citationBentley, A. M., Menz, G., Storz, C., Robinson, D. S., Bradley, B., Jeffery, P. K., Durham, S. R., & Kay, A. B. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/146.2.500 · Cited by 407
Tenascin Is Increased in Airway Basement Membrane of Asthmatics and Decreased by an Inhaled Steroid
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Self-citationHigh prevalence of asthma in cross country skiers.
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Cited by
Asthma: defining of the persistent adult phenotypes
Wenzel, S. E. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69290-8 · Cited by 1,043
Tenascins: regulation and putative functions during pathological stress
Chiquet‐Ehrismann, R., & Chiquet, M. (2003) · The Journal of Pathology · doi:10.1002/path.1415 · Cited by 549
The role of tenascin-C in tissue injury and tumorigenesis
Midwood, K. S., & Orend, G. (2009) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-009-0075-1 · Cited by 438
Airway injury as a mechanism for exercise-induced bronchoconstriction in elite athletes
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Asthma, Airway Inflammation and Epithelial Damage in Swimmers and Cold-Air Athletes
Bougault, V., Turmel, J., St-Laurent, J., Bertrand, M., & Boulet, L.-P. (2009) · European Respiratory Journal · doi:10.1183/09031936.00117708 · Cited by 170
Metadata
- Authors
- KARJALAINEN, E.-M., LAITINEN, A., SUE-CHU, M., ALTRAJA, A., BJERMER, L., & LAITINEN, L. A.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-06-01
- Volume
- 161
- Issue
- 6
- Pages
- 2086-2091
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2044754321
- Cited by
- 317
- References
- 20
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- KARJALAINEN, E.-M., LAITINEN, A., SUE-CHU, M., ALTRAJA, A., BJERMER, L., & LAITINEN, L. A. (2000). Evidence of Airway Inflammation and Remodeling in Ski Athletes with and without Bronchial Hyperresponsiveness to Methacholine. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.161.6.9907025
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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