The DOI matches its Crossref record; 227 of the 227 references it cites were found in a registry or an index.
The role of tenascin-C in tissue injury and tumorigenesis
Open accessAbstract
The extracellular matrix molecule tenascin-C is highly expressed during embryonic development, tissue repair and in pathological situations such as chronic inflammation and cancer. Tenascin-C interacts with several other extracellular matrix molecules and cell-surface receptors, thus affecting tissue architecture, tissue resilience and cell responses. Tenascin-C modulates cell migration, proliferation and cellular signaling through induction of pro-inflammatory cytokines and oncogenic signaling molecules amongst other mechanisms. Given the causal role of inflammation in cancer progression, common mechanisms might be controlled by tenascin-C during both events. Drugs targeting the expression or function of tenascin-C or the tenascin-C protein itself are currently being developed and some drugs have already reached advanced clinical trials. This generates hope that increased knowledge about tenascin-C will further improve management of diseases with high tenascin-C expression such as chronic inflammation, heart failure, artheriosclerosis and cancer.
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Cites
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“Parallels between tenascin-C-associated inflammation, the repair process and tumorigenesis Clinical and epidemiologic studies suggest a strong association between inflammation and cancer (Coussens and Werb 2002; Hussain et al. 2003; Lin and Karin 2007; Shacter and Weitzman 2002).”
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Cited by
The Role of Cancer-Associated Fibroblasts and Fibrosis in Liver Cancer
Affo, S., Yu, L.-X., & Schwabe, R. F. (2017) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-052016-100322 · Cited by 757
Midwood, K. S., Chiquet, M., Tucker, R. P., & Orend, G. (2016) · Journal of Cell Science · doi:10.1242/jcs.190546 · Cited by 429
Self-citationThe interplay of fibroblasts, the extracellular matrix, and inflammation in scar formation
Moretti, L., Stalfort, J., Barker, T. H., & Abebayehu, D. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101530 · Cited by 393
Tenascin C in metastasis: A view from the invasive front
Lowy, C. M., & Oskarsson, T. (2015) · Cell Adhesion & Migration · doi:10.1080/19336918.2015.1008331 · Cited by 178
Tenascin-X: beyond the architectural function
Valcourt, U., Alcaraz, L. B., Exposito, J.-Y., Lethias, C., & Bartholin, L. (2015) · Cell Adhesion & Migration · doi:10.4161/19336918.2014.994893 · Cited by 132
Metadata
- Authors
- Midwood, K. S., & Orend, G.
- Venue
- Journal of Cell Communication and Signaling
- Publisher
- Wiley
- Published
- 2009-10-17
- Volume
- 3
- Issue
- 3-4
- Pages
- 287-310
- ISSN
- 1873-9601 (ISSN-L)
- 1873-961X
- OpenAlex
- W2014868340
- Cited by
- 438
- References
- 227
- FWCI
- 11.86
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
