The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Relation between Respiratory Changes in Arterial Pulse Pressure and Fluid Responsiveness in Septic Patients with Acute Circulatory Failure
Abstract
In mechanically ventilated patients with acute circulatory failure related to sepsis, we investigated whether the respiratory changes in arterial pressure could be related to the effects of volume expansion (VE) on cardiac index (CI). Forty patients instrumented with indwelling systemic and pulmonary artery catheters were studied before and after VE. Maximal and minimal values of pulse pressure (Pp(max) and Pp(min)) and systolic pressure (Ps(max) and Ps(min)) were determined over one respiratory cycle. The respiratory changes in pulse pressure (DeltaPp) were calculated as the difference between Pp(max) and Pp(min) divided by the mean of the two values and were expressed as a percentage. The respiratory changes in systolic pressure (DeltaPs) were calculated using a similar formula. The VE-induced increase in CI was >/= 15% in 16 patients (responders) and < 15% in 24 patients (nonresponders). Before VE, DeltaPp (24 +/- 9 versus 7 +/- 3%, p < 0.001) and DeltaPs (15 +/- 5 versus 6 +/- 3%, p < 0.001) were higher in responders than in nonresponders. Receiver operating characteristic (ROC) curves analysis showed that DeltaPp was a more accurate indicator of fluid responsiveness than DeltaPs. Before VE, a DeltaPp value of 13% allowed discrimination between responders and nonresponders with a sensitivity of 94% and a specificity of 96%. VE-induced changes in CI closely correlated with DeltaPp before volume expansion (r(2) = 0. 85, p < 0.001). VE decreased DeltaPp from 14 +/- 10 to 7 +/- 5% (p < 0.001) and VE-induced changes in DeltaPp correlated with VE-induced changes in CI (r(2) = 0.72, p < 0.001). It was concluded that in mechanically ventilated patients with acute circulatory failure related to sepsis, analysis of DeltaPp is a simple method for predicting and assessing the hemodynamic effects of VE, and that DeltaPp is a more reliable indicator of fluid responsiveness than DeltaPs.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Individual Comparisons by Ranking Methods
Wilcoxon, F. (1945) · Biometrics Bulletin · doi:10.2307/3001968 · Cited by 15,354
Cited by
Barbier, C., Loubières, Y., Schmit, C., Hayon, J., Ricôme, J.-L., Jardin, F., & Vieillard-Baron, A. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2259-8 · Cited by 940
Jansen, T. C., van Bommel, J., Schoonderbeek, F. J., Sleeswijk Visser, S. J., van der Klooster, J. M., Lima, A. P., Willemsen, S. P., & Bakker, J. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200912-1918oc · Cited by 894
Marik, P. E., & Cavallazzi, R. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31828a25fd · Cited by 866
Antonelli, M., Levy, M., Andrews, P. J. D., Chastre, J., Hudson, L. D., Manthous, C., Meduri, G. U., Moreno, R. P., Putensen, C., Stewart, T., et al. (2007) · Intensive Care Medicine · doi:10.1007/s00134-007-0531-4 · Cited by 466
Less invasive hemodynamic monitoring in critically ill patients
Teboul, J.-L., Saugel, B., Cecconi, M., De Backer, D., Hofer, C. K., Monnet, X., Perel, A., Pinsky, M. R., Reuter, D. A., Rhodes, A., et al. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4375-7 · Cited by 328
Self-citation
Metadata
- Authors
- MICHARD, F., BOUSSAT, S., CHEMLA, D., ANGUEL, N., MERCAT, A., LECARPENTIER, Y., RICHARD, C., PINSKY, M. R., & TEBOUL, J.-L.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-07-01
- Volume
- 162
- Issue
- 1
- Pages
- 134-138
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2144408525
- Cited by
- 1,458
- References
- 1
- FWCI
- 25.95
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Relation between Respiratory Changes in Arterial Pulse Pressure and Fluid Responsiveness in Septic Patients with Acute Circulatory Failure. https://app.cochat.ai/papers/10.1164/ajrccm.162.1.9903035
- The paper
- MICHARD, F., BOUSSAT, S., CHEMLA, D., ANGUEL, N., MERCAT, A., LECARPENTIER, Y., RICHARD, C., PINSKY, M. R., & TEBOUL, J.-L. (2000). Relation between Respiratory Changes in Arterial Pulse Pressure and Fluid Responsiveness in Septic Patients with Acute Circulatory Failure. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.162.1.9903035
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
