The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
An Investigation into Causative Factors in Patients with Bronchiectasis
Abstract
Bronchiectasis is a pathologic description of lung damage characterized by inflamed and dilated thick-walled bronchi. These findings may result from a number of possible causes and these may influence treatment and prognosis. The aim of this study was to determine causative factors in 150 adults with bronchiectasis (56 male, 94 female) identified using high-resolution computerized tomography. Relevant factors were identified in the clinical history; cystic fibrosis gene mutation analysis was performed; humoral immune defects were determined by measuring immunoglobulins, IgG subclasses and functional response to Pneumovax II vaccine; assessment was made of neutrophil function (respiratory burst, adhesion molecule expression, and chemotaxis); ciliary function was observed and those likely to have allergic bronchopulmonary aspergillosis (ABPA) were identified. Causes identified were: immune defects (12 cases), cystic fibrosis (4), Young's syndrome (5), ciliary dysfunction (3), aspiration (6), panbronchiolitis (1), congenital defect (1), ABPA (11), rheumatoid arthritis (4), and early childhood pneumonia, pertussis, or measles (44). Intensive investigation of this population of patients with bronchiectasis led to identification of one or more causative factor in 47% of cases. In 22 patients (15%), the cause identified had implications for prognosis and treatment.
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Cites
Effect of pneumonia and whooping cough in childhood on adult lung function
Johnston, I. D. A., Strachan, D. P., & Anderson, H. R. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802263380904 · Cited by 169
Cited by
The bronchiectasis severity index. An international derivation and validation study
Chalmers, J. D., Goeminne, P., Aliberti, S., McDonnell, M. J., Lonni, S., Davidson, J., Poppelwell, L., Salih, W., Pesci, A., Dupont, L. J., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201309-1575oc · Cited by 1,093
Tunney, M. M., Einarsson, G. G., Wei, L., Drain, M., Klem, E. R., Cardwell, C., Ennis, M., Boucher, R. C., Wolfgang, M. C., & Elborn, J. S. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201210-1937oc · Cited by 316
A novel microbiota stratification system predicts future exacerbations in bronchiectasis
Rogers, G. B., Zain, N. M. M., Bruce, K. D., Burr, L. D., Chen, A. C., Rivett, D. W., McGuckin, M. A., & Serisier, D. J. (2014) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201310-335oc · Cited by 244
Javidan-Nejad, C., & Bhalla, S. (2009) · Radiologic clinics of North America · doi:10.1016/j.rcl.2008.11.006 · Cited by 49
Hayes, D., Kopp, B. T., Tobias, J. D., Woodley, F. W., Mansour, H. M., Tumin, D., & Kirkby, S. E. (2015) · Lung · doi:10.1007/s00408-015-9811-x · Cited by 18
Metadata
- Authors
- PASTEUR, M. C., HELLIWELL, S. M., HOUGHTON, S. J., WEBB, S. C., FOWERAKER, J. E., COULDEN, R. A., FLOWER, C. D., BILTON, D., & KEOGAN, M. T.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-10-01
- Volume
- 162
- Issue
- 4
- Pages
- 1277-1284
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W1976858537
- Cited by
- 684
- References
- 1
- FWCI
- 9.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- PASTEUR, M. C., HELLIWELL, S. M., HOUGHTON, S. J., WEBB, S. C., FOWERAKER, J. E., COULDEN, R. A., FLOWER, C. D., BILTON, D., & KEOGAN, M. T. (2000). An Investigation into Causative Factors in Patients with Bronchiectasis. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.162.4.9906120
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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