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Expression of the Cysteinyl Leukotriene 1 Receptor in Normal Human Lung and Peripheral Blood Leukocytes
Abstract
The cysteinyl leukotrienes (CysLTs) are important mediators of human asthma. Pharmacologic and clinical studies show that the CysLTs exert most of their bronchoconstrictive and proinflammatory effects through activation of a putative, 7-transmembrane domain, G-protein-coupled receptor, the CysLT1 receptor. The initial molecular characterization of the CysLT1 receptor showed by in situ hybridization, the presence of CysLT1 receptor messenger RNA (mRNA) in human lung smooth-muscle cells and lung macrophages. We confirmed the results of these in situ hybridization analyses for the CysLT1 receptor, and produced the first immunohistochemical characterization of the CysLT1 receptor protein in human lung. The identification of the CysLT1 receptor in the lung is consistent with the antibronchoconstrictive and antiinflammatory actions of CysLT1 receptor antagonists. We also report the expression of CysLT1 receptor mRNA and protein in most peripheral blood eosinophils and pregranulocytic CD34+ cells, and in subsets of monocytes and B lymphocytes.
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Cited by
Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling
Holgate, S. T., Peters-Golden, M., Panettieri, R. A., & Henderson, W. R. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.25 · Cited by 318
International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors
Brink, C., Dahlén, S.-E., Drazen, J., Evans, J. F., Hay, D. W. P., Nicosia, S., Serhan, C. N., Shimizu, T., & Yokomizo, T. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.8 · Cited by 286
Self-citationMast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation
Boyce, J. A. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00512.x · Cited by 254
Mast cell mediators in allergic inflammation and mastocytosis
Castells, M. (2006) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2006.05.005 · Cited by 112
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Togias, A. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.09.051 · Cited by 102
Metadata
- Authors
- FIGUEROA, D. J., BREYER, R. M., DEFOE, S. K., KARGMAN, S., DAUGHERTY, B. L., WALDBURGER, K., LIU, Q., CLEMENTS, M., ZENG, Z., O'NEILL, G. P., JONES, T. R., LYNCH, K. R., AUSTIN, C. P., & EVANS, J. F.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-01-01
- Volume
- 163
- Issue
- 1
- Pages
- 226-233
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2152288642
- Cited by
- 262
- References
- 0
- FWCI
- 16.03
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Expression of the Cysteinyl Leukotriene 1 Receptor in Normal Human Lung and Peripheral Blood Leukocytes. https://app.cochat.ai/papers/10.1164/ajrccm.163.1.2003101
- The paper
- FIGUEROA, D. J., BREYER, R. M., DEFOE, S. K., KARGMAN, S., DAUGHERTY, B. L., WALDBURGER, K., LIU, Q., CLEMENTS, M., ZENG, Z., O'NEILL, G. P., JONES, T. R., LYNCH, K. R., AUSTIN, C. P., & EVANS, J. F. (2001). Expression of the Cysteinyl Leukotriene 1 Receptor in Normal Human Lung and Peripheral Blood Leukocytes. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.163.1.2003101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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