The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation
Abstract
Summary: When activated by specific antigen, complement, or other transmembrane stimuli, mast cells (MCs) generate three eicosanoids: prostaglandin (PG)D 2, leukotriene (LT)B 4, and LTC 4, the parent molecule of the cysteinyl leukotrienes (cysLTs). These diverse lipid mediators, which are generated from a single cell membrane‐associated precursor, arachidonic acid, can initiate, amplify, or dampen inflammatory responses and influence the magnitude, duration, and nature of subsequent immune responses. PGD 2 and cysLTs, which were originally recognized for their bronchoconstricting and vasoactive properties, also serve diverse and pivotal functions in effector cell trafficking, antigen presentation, leukocyte activation, matrix deposition, and fibrosis. LTB 4 is a powerful chemoattractant for neutrophils and certain lymphocyte subsets. Thus, MCs can contribute to each of these processes through eicosanoid generation. Additionally, MCs express G‐protein‐coupled receptors specific for cysLTs, LTB 4, and another eicosanoid, PGE 2. Each of these receptors can regulate MC functions in vivo by autocrine and paracrine mechanisms. This review focuses on the biologic functions for MC‐associated eicosanoids, the regulation of their production, and the mechanisms by which eicosanoids may regulate MC function in host defense and disease.
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The development of allergic inflammation
Galli, S. J., Tsai, M., & Piliponsky, A. M. (2008) · Nature · doi:10.1038/nature07204 · Cited by 1,839
IgE and mast cells in allergic disease
Galli, S. J., & Tsai, M. (2012) · Nature Medicine · doi:10.1038/nm.2755 · Cited by 1,799
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Galli, S. J., Borregaard, N., & Wynn, T. A. (2011) · Nature Immunology · doi:10.1038/ni.2109 · Cited by 1,055
Mast Cell: A Multi-Functional Master Cell
Krystel-Whittemore, M., Dileepan, K. N., & Wood, J. G. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00620 · Cited by 890
Metadata
- Authors
- Boyce, J. A.
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2007-05-07
- Volume
- 217
- Issue
- 1
- Pages
- 168-185
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- OpenAlex
- W2038960406
- Cited by
- 254
- References
- 158
- FWCI
- 0.68
- Type
- journal article
- Language
- en
- Open access
- closed
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- Boyce, J. A. (2007). Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation. Immunological Reviews. https://doi.org/10.1111/j.1600-065x.2007.00512.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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