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Cited by 213

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Nocturnal Oxygen Therapy in Patients with the Eisenmenger Syndrome

SANDOVAL, JULIO, AGUIRRE, JANET S., PULIDO, TOMÁS, MARTINEZ-GUERRA, MARIA LUISA, SANTOS, EFRÉN, ALVARADO, PEDRO, ROSAS, MARTIN, BAUTISTA, EDGAR·2001·American Journal of Respiratory and Critical Care Medicine

Abstract

This prospective and controlled pilot study evaluates the long-term effects of nocturnal oxygen therapy (NOT) on exercise endurance, hematology variables, quality of life, and survival of 23 adult patients (mean age, 32 +/- 6 yr) with post-tricuspid congenital heart defects (ventricular septal defect = 10; patent ductus arteriosus = 13) and Eisenmenger Syndrome. All had pulmonary hypertension (mean pulmonary artery pressure = 88 +/- 20 mm Hg), severe hypoxemia (Pa(O(2)) = 44 +/- 5 mm Hg), and secondary erythrocytosis (hematocrit = 61.5 +/- 7%). Exercise endurance (6-min walk test = 380 +/- 88 m) was limited. In a random fashion, NOT was given to one group of patients (n = 12) but withheld from a comparable control group (n = 11). At 2 yr of close follow-up, two patients in the group of control patients, and three in the treatment group died. Mean survival estimates were similar in both groups (20.7 versus 20.8 mo; chi-square log-rank, 0.08; p = NS). Likewise, none of the hematology, exercise capacity, and quality of life variables examined showed statistically significant changes that were dependent on treatment regimen. We conclude that NOT does not modify the natural history of patients with advanced Eisenmenger Syndrome.

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Metadata

Authors
SANDOVAL, J., AGUIRRE, J. S., PULIDO, T., MARTINEZ-GUERRA, M. L., SANTOS, E., ALVARADO, P., ROSAS, M., & BAUTISTA, E.
Venue
American Journal of Respiratory and Critical Care Medicine
Published
2001-11-01
Volume
164
Issue
9
Pages
1682-1687
ISSN
  • 1073-449X (ISSN-L)
  • 1535-4970
OpenAlex
W2037260910
Cited by
213
References
1
FWCI
5.51
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Nocturnal Oxygen Therapy in Patients with the Eisenmenger Syndrome. https://app.cochat.ai/papers/10.1164/ajrccm.164.9.2106076
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SANDOVAL, J., AGUIRRE, J. S., PULIDO, T., MARTINEZ-GUERRA, M. L., SANTOS, E., ALVARADO, P., ROSAS, M., & BAUTISTA, E. (2001). Nocturnal Oxygen Therapy in Patients with the Eisenmenger Syndrome. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.164.9.2106076

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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