The DOI matches its Crossref record.
Urinary Leukotriene E 4 Concentrations Increase after Aspirin Challenge in Aspirin-sensitive Asthmatic Subjects
Abstract
Urinary leukotriene E4 (LTE4) concentrations have been measured in six asthmatic patients with aspirin sensitivity and in five asthmatic subjects tolerant of aspirin, before and after provocation with aspirin or placebo. Aspirin-sensitive subjects showed an average 21% fall in FEV1 after aspirin challenge whereas control individuals had a 2% fall in FEV1 after ingestion of 100 mg aspirin. The resting urinary LTE4 concentrations in asthmatic subjects sensitive to aspirin were 243 pg/mg creatinine (range 50 to 1,041), and these were on average sixfold greater than those in control asthmatic subjects. Further, there was a mean fourfold increase in urinary LTE4 levels at 3 to 6 h after aspirin, but not placebo, challenge in aspirin-sensitive asthmatic subjects that was not seen in the control asthmatic individuals. Leukotriene release may play a central role in the mechanisms of asthmatic attacks produced by aspirin ingestion.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Drug Allergy: An Updated Practice Parameter
(2010) · Annals of Allergy, Asthma & Immunology · doi:10.1016/j.anai.2010.08.002 · Cited by 957
Dykewicz, M. S., Fineman, S., Skoner, D. P., Nicklas, R., Lee, R., Blessing-Moore, J., Li, J. T., Bernstein, I. L., Berger, W., Spector, S., et al. (1998) · Annals of Allergy, Asthma & Immunology · doi:10.1016/s1081-1206(10)63155-9 · Cited by 652
EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity
Niżankowska‐Mogilnicka, E., Bochenek, G., Mastalerz, L., Świerczyńska, M., Picado, C., Scadding, G., Kowalski, M. L., Setkowicz, M., Ring, J., Brockow, K., et al. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01409.x · Cited by 406
DAHLÉN, B., NIZANKOWSKA, E., SZCZEKLIK, A., ZETTERSTRÖM, O., BOCHENEK, G., KUMLIN, M., MASTALERZ, L., PINIS, G., SWANSON, L. J., BOODHOO, T. I., et al. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.4.9707089 · Cited by 396
Szefler, S. J., Wenzel, S., Brown, R., Erzurum, S. C., Fahy, J. V., Hamilton, R. G., Hunt, J. F., Kita, H., Liu, A. H., Panettieri, R. A., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.12.979 · Cited by 395
Metadata
- Authors
- Christie, P. E., Tagari, P., Ford-Hutchinson, A. W., Charlesson, S., Chee, P., Arm, J. P., & Lee, T. H.
- Venue
- American Review of Respiratory Disease
- Publisher
- Oxford University Press (OUP)
- Published
- 1991-05
- Volume
- 143
- Issue
- 5_pt_1
- Pages
- 1025-1029
- ISSN
- 0003-0805 (ISSN-L)
- OpenAlex
- W2044880620
- Cited by
- 449
- References
- 0
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Urinary Leukotriene E 4 Concentrations Increase after Aspirin Challenge in Aspirin-sensitive Asthmatic Subjects. https://app.cochat.ai/papers/10.1164/ajrccm/143.5_pt_1.1025
- The paper
- Christie, P. E., Tagari, P., Ford-Hutchinson, A. W., Charlesson, S., Chee, P., Arm, J. P., & Lee, T. H. (1991). Urinary Leukotriene E 4 Concentrations Increase after Aspirin Challenge in Aspirin-sensitive Asthmatic Subjects. American Review of Respiratory Disease. https://doi.org/10.1164/ajrccm/143.5_pt_1.1025
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
