The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Elevated Release of Tumor Necrosis Factor-alpha and Interferon-gamma by Bronchoalveolar Leukocytes from Patients with Bronchial Asthma
Abstract
Bronchoalveolar lavage (BAL) leukocyte-secreted cytokines are considered to be important mediators of the inflammatory and allergic reactions in the lung. This study examines quantitative changes in the level of tumor necrosis factor-alpha (TNF alpha) and interferon-gamma (IFN gamma) production in BAL cell cultures derived from patients (n = 11) with bronchial asthma. The secretion of TNF alpha and IFN gamma was determined in intact (unstimulated) and phytohemagglutinin/phorbol myristate acetate (PHA + PMA)-stimulated BAL leukocyte cultures and compared with that in control cultures. In all patients studied, the background and PHA + PMA-induced secretion of TNF alpha and IFN gamma was significantly (p < 0.001) higher than that in parallel control cultures. In contrast to BAL cell preparations, the capacity of TNF alpha and IFN gamma secretion by patients' peripheral blood mononuclear cells (PBMC) did not differ from that of control subjects. High spontaneous release of TNF alpha and IFN gamma by patients' BAL leukocytes, but not PBMC, suggest that in the pathophysiology of bronchial asthma, these cytokines may act as local pathogenic agents in the lung.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Comparison of in vitro cell cytotoxic assays for tumor necrosis factor
Flick, D. A., & Gifford, G. E. (1984) · Journal of Immunological Methods · doi:10.1016/0022-1759(84)90147-9 · Cited by 745
Scott, H. A., Garg, M. L., Gibson, P. G., & Wood, L. G. (2013) · Nutrition and physical activity in inflammatory diseases · doi:10.1079/9781845939106.0299 · Cited by 571
Robinson, B. W., McLemore, T. L., & Crystal, R. G. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111852 · Cited by 458
Corrigan, C. J., & Kay, A. B. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.4_pt_1 · Cited by 384
Induction of the synthesis of tumor necrosis factor receptors by interferon-gamma.
Ruggiero, V, Tavernier, J., Fiers, W., & Baglioni, C. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2445 · Cited by 318
Pène, J., Rousset, F., Brière, F., Chrétien, I., Paliard, X., Banchereau, J., Spits, H., & De Vries, J. E. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.4.1218 · Cited by 313
Interferon-gamma enhances expression of cellular receptors for tumor necrosis factor.
Tsujimoto, M., Yip, Y. K., & Vilček, J. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.7.2441 · Cited by 301
Gosset, P., Tsicopoulos, A., Wallaert, B., Vannimenus, C., Joseph, M., Tonnel, A., & Capron, A. (1991) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(91)90149-i · Cited by 262
Godard, P., Chaintreuil, J., Damon, M., Coupe, M., Flandre, O., de Paulet, A. C., & Michel, F. B. (1982) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(82)90234-2 · Cited by 178
IFN-gamma enhances endothelial activation induced by tumor necrosis factor but not IL-1.
Doukas, J., & Pober, J. S. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.6.1727 · Cited by 172
Cited by
TNF-mediated inflammatory disease
Bradley, Jr. (2008) · The Journal of Pathology · doi:10.1002/path.2287 · Cited by 2,094
Busse, W. W., & Lemanske, R. F. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102013440507 · Cited by 1,606
Inflammatory Mediators of Asthma: An Update
Barnes, P. J., Chung, K. F., & Page, C. P. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01381-4 · Cited by 717
Hansen, G., Berry, G., DeKruyff, R. H., & Umetsu, D. T. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5155 · Cited by 629
Asthma: an epidemic of dysregulated immunity
Umetsu, D. T., McIntire, J. J., Akbari, O., Macaubas, C., & DeKruyff, R. H. (2002) · Nature Immunology · doi:10.1038/ni0802-715 · Cited by 599
Metadata
- Authors
- Cembrzynska-Nowak, M., Szklarz, E., Inglot, A. D., & Teodorczyk-Injeyan, J. A.
- Venue
- American Review of Respiratory Disease
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-02
- Volume
- 147
- Issue
- 2
- Pages
- 291-295
- ISSN
- 0003-0805 (ISSN-L)
- OpenAlex
- W2052863900
- Cited by
- 260
- References
- 15
- FWCI
- 4.16
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Elevated Release of Tumor Necrosis Factor-alpha and Interferon-gamma by Bronchoalveolar Leukocytes from Patients with Bronchial Asthma. https://app.cochat.ai/papers/10.1164/ajrccm/147.2.291
- The paper
- Cembrzynska-Nowak, M., Szklarz, E., Inglot, A. D., & Teodorczyk-Injeyan, J. A. (1993). Elevated Release of Tumor Necrosis Factor-alpha and Interferon-gamma by Bronchoalveolar Leukocytes from Patients with Bronchial Asthma. American Review of Respiratory Disease. https://doi.org/10.1164/ajrccm/147.2.291
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
