The DOI matches its Crossref record.
Pulmonary Alveolar Proteinosis and Aluminum Dust Exposure
Abstract
A 44-yr-old male presented with shortness of breath, diffuse X-ray infiltrates, and physiologic evidence of a restrictive lung disease. Biopsy revealed pulmonary alveolar proteinosis. The patient had worked for the previous 6 yr as an aluminum rail grinder in a very dusty environment. Analysis of his lung tissue revealed greater than 300 x 106 particles of aluminum/g dry lung; all of the particles appeared as spheres of less than 1 μ diameter. We believe that this case represents an example of pulmonary alveolar proteinosis induced by inhalation of aluminum particles; this finding confirms animal studies which suggest that proteinosis can be produced by very large doses of many types of finely divided mineral dust.
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Pulmonary lesions in humans linked to Al exposure during production of Al products include granulomatous pneumonia, pulmonary granulomatosis, pulmonary fibrosis, pulmonary alveolar proteinosis and desquamative interstitial pneumonia.
“Pulmonary lesions in humans linked to Al exposure during production of Al products include granulomatous pneumonia, pulmonary granulomatosis, pulmonary fibrosis, pulmonary alveolar proteinosis and desquamative interstitial pneumonia (Chen et al., 1978; Herbert et al., 1982; Miller et al., 1984; De Vuyst et al., 1987; Jederlinic et al., 1990; Taiwo, 2014; Iijima et al., 2017).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Miller et al., 1984
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Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
Krewski, D., Yokel, R. A., Nieboer, E., Borchelt, D., Cohen, J., Harry, J., Kacew, S., Lindsay, J., Mahfouz, A. M., & Rondeau, V. (2007) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701597766 · Cited by 998
Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395
“Pulmonary effect Pulmonary lesions in humans linked to Al exposure during production of Al products include granulomatous pneumonia, pulmonary granulomatosis, pulmonary fibrosis, pulmonary alveolar proteinosis and desquamative interstitial pneumonia (Chen et al., 1978; Herbert et al., 1982; Miller et al., 1984; De Vuy…”
Background
Metadata
- Authors
- Miller, R. R., Churg, A. M., Hutcheon, M., & Lam, S.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Miller, Roberta R.
- Venue
- American Review of Respiratory Disease
- Publisher
- Oxford University Press (OUP)
- Published
- 1984-08-01
- Volume
- 130
- Issue
- 2
- Pages
- 312-315
- ISSN
- 0003-0805 (ISSN-L)
- OpenAlex
- W1824141053
- Cited by
- 126
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 6 · 2022: 4 · 2020: 1 · 2019: 7 · 2018: 2 · 2017: 3 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 2
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Review of Respiratory Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Medical Imaging and Pathology Studies
- Keywords
- pulmonary alveolar proteinosis, aluminum particles, occupational dust inhalation, restrictive lung disease, lung biopsy, rail grinding
- MeSH terms
- Adult, Aluminum, Biopsy, Dust, Environmental Exposure, Humans, Lung, Male, Pulmonary Alveolar Proteinosis
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