The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
The Effect of Fluid Loading, Blood Transfusion, and Catecholamine Infusion on Oxygen Delivery and Consumption in Patients with Sepsis 1, 2
Abstract
Fifty-four patients with systemic sepsis and signs of circulatory shock were prospectively investigated immediately before and after 1 of 3 therapeutic interventions chosen to increase systemic oxygen delivery (DO2): colloidal fluid loading (Group I, n = 20), blood transfusion (Group II, n = 17), or catecholamine infusion (dopamine or dobutamine, Group III, n = 17). Patients in Groups I and II with normal blood lactate concentrations (less than 2.2 mmol/L) exhibited no significant increases in systemic oxygen consumption (VO2) in response to the increases in DO2. However, significant increases in VO2 were noted in patients in Groups I and II with elevated lactate concentrations (greater than 2.2 mmol/L). In contrast to patients in Groups I and II, patients in Group III with and without lactic acidosis exhibited significant increases in VO2 after catecholamine administration. Lactic acidosis, a clinical marker of anaerobic metabolism or oxygen debt, appears to predict increases in VO2 in response to increases in DO2 in septic patients receiving fluid and catecholamines increase VO2 without regard for the presence or absence of anaerobic metabolism. The results of this clinical trial therefore suggest that catecholamines may exert a direct effect on oxidative metabolism.
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Cites
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Abnormal Vascular Tone, Defective Oxygen Transport And Myocardial Failure In Human Septic Shock
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Defective oxidative metabolism of rat liver mitochondria in hemorrhagic and endotoxin shock
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HEMODYNAMIC AND METABOLIC STUDIES ON SHOCK ASSOCIATED WITH GRAM NEGATIVE BACTEREMIA
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Cited by
Pathogenetic Mechanisms of Septic Shock
Epstein, F. H., & Parrillo, J. E. (1993) · New England Journal of Medicine · doi:10.1056/nejm199305203282008 · Cited by 1,548
Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients
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Has the mortality of septic shock changed with time?
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Clinical consequences of red cell storage in the critically ill
Tinmouth, A., Fergusson, D., Yee, I. C., Hébert, P. C., & ABLE Investigators and the Canadian Critical Care Trials Group (2006) · Transfusion · doi:10.1111/j.1537-2995.2006.01026.x · Cited by 577
Metadata
- Authors
- Gilbert, E. M., Haupt, M. T., Mandanas, R. Y., Huaringa, A. J., & Carlson, R. W.
- Venue
- American Review of Respiratory Disease
- Publisher
- Oxford University Press (OUP)
- Published
- 1986-11
- Volume
- 134
- Issue
- 5
- Pages
- 873-878
- ISSN
- 0003-0805 (ISSN-L)
- OpenAlex
- W1936689747
- Cited by
- 366
- References
- 17
- FWCI
- 9.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Effect of Fluid Loading, Blood Transfusion, and Catecholamine Infusion on Oxygen Delivery and Consumption in Patients with Sepsis 1, 2. https://app.cochat.ai/papers/10.1164/arrd.1986.134.5.873
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- Gilbert, E. M., Haupt, M. T., Mandanas, R. Y., Huaringa, A. J., & Carlson, R. W. (1986). The Effect of Fluid Loading, Blood Transfusion, and Catecholamine Infusion on Oxygen Delivery and Consumption in Patients with Sepsis 1, 2. American Review of Respiratory Disease. https://doi.org/10.1164/arrd.1986.134.5.873
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
