Pathogenetic Mechanisms of Septic Shock
Abstract
One of the most frequent and serious problems confronting clinicians is the management of a serious infection and the systemic response to infection, a syndrome termed sepsis. When this syndrome results in hypotension and organ dysfunction, it is called septic shock. Septic shock is the most common cause of death in intensive care units,1 and it is the 13th most common cause of death in the United States2. The incidence of the two disorders continues to rise: 400,000 cases of sepsis and 200,000 episodes of septic shock are estimated to occur annually, resulting in more than 100,000 deaths1. . . .
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Massive activation of innate immunity caused by LPS leads to excess production of cytokines and development of septic shock or endotoxin shock syndrome.
“Massive activation of innate immunity caused by LPS leads to excess production of cytokines and other molecules, and development of septic shock or endotoxin shock syndrome, a fatal syndrome that is characterized by fever, hypotension, disseminated intravascular coagulation, and multiple organ failure [7].”
From Prolyl Isomerase Pin1 Protects Mice from Endotoxin Shock (2011) · cites this paper as [7]
Inflammation caused by LPS leads to the development of multiple organ failures in vivo.
“Inflammation caused by LPS leads to the development of multiple organ failures in vivo [7].”
From Prolyl Isomerase Pin1 Protects Mice from Endotoxin Shock (2011) · cites this paper as [7]
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“Inflammation caused by LPS leads to the development of multiple organ failures in vivo [7].”
Background
- Authors
- Epstein, F. H., & Parrillo, J. E.
- Affiliations
- Rush University Medical Center (US)
- Corresponding author
- Parrillo, Joseph E.
- ORCID
- Parrillo, Joseph E.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1993-05-20
- Volume
- 328
- Issue
- 20
- Pages
- 1471-1477
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2067338751
- Cited by
- 1,548
- References
- 0
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 14 · 2023: 14 · 2022: 9 · 2021: 23 · 2020: 12 · 2019: 19 · 2018: 21 · 2017: 20 · 2016: 19 · 2015: 23 · 2014: 27 · 2013: 45 · 2012: 38
- FWCI
- 23.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
- Keywords
- septic shock, sepsis, pathogenesis, systemic inflammatory response, hypotension, organ dysfunction, serious infections
- MeSH terms
- Animals, Cardiovascular System, Endotoxins, Humans, Multiple Organ Failure, Shock, Septic, Myocardial Ischemia
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