Cited by 102Neuroscience of respiration and sleepPrenatal Substance Exposure EffectsNeonatal Respiratory Health Research

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Prenatal Nicotine Exposure Blunts the Cardiorespiratory Response to Hypoxia in Lambs

Hafström, Ola, Milerad, Joseph, Sundell, Håkan W.·2002·American Journal of Respiratory and Critical Care Medicine

DOI 10.1164/rccm.200204-289oc

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Abstract

Because smoking during pregnancy is a major risk factor for late fetal death and the sudden infant death syndrome, we investigated cardiorespiratory defense mechanisms to hypoxia in 7 prenatally nicotine-exposed (N) lambs (approximate maternal dose: 0.5 mg/kg/day) and 11 control (C) lambs all at an average age of 5 days. The ventilatory response to 10% oxygen (hyperpnea) was significantly attenuated during quiet sleep in N lambs compared with C lambs and in N lambs aroused from sleep later compared with C lambs (161 +/- 90 versus 75 +/- 66 seconds, p < 0.05). The ventilatory response to hypoxia was similar in the two groups during wakefulness (W), whereas the heart rate response (tachycardia) was significantly lower in N lambs compared with C lambs during both activity states. The ventilatory response to hyperoxia was significantly lower in N lambs compared with C lambs during both activity states. Transition from W to quiet sleep was associated with a significant decrease in ventilation in C lambs but not in N lambs. In conclusion, prenatal nicotine exposure, at a dose comparable with moderate smoking, blunts major elements of the cardiorespiratory defense to hypoxia, i.e., the heart rate and ventilatory and arousal responses, and abolishes the normal decrease in ventilation during sleep compared with W.

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Authors: Hafström, O., Milerad, J., & Sundell, H. W.
Affiliations: Vanderbilt University (US)
Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee
ORCID: Milerad, Joseph
Venue: American Journal of Respiratory and Critical Care Medicine
Publisher: Oxford University Press (OUP)
Published: 2002-12
Volume: 166
Issue: 12
Pages: 1544-1549
ISSN: 1073-449X (ISSN-L)
1535-4970
DOI: 10.1164/rccm.200204-289oc
OpenAlex: W2108907303
Cited by: 102
References: 52
Citations by year: 2025: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 3 · 2013: 2 · 2012: 6
FWCI: 2.21
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: American Journal of Respiratory and Critical Care Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01hd028916-04, 5p50hl014214-25)
National Heart, Lung, and Blood Institute (HL14214)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD28916)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
Keywords: prenatal nicotine exposure, maternal smoking, hypoxia, ventilatory response, heart rate, hyperoxia, sleep arousal, lambs, sudden infant death syndrome, fetal death
MeSH terms: Animals, Hypoxia, Blood Pressure, Chemoreceptor Cells, Female, Heart Rate, Nicotine, Pregnancy, Prenatal Exposure Delayed Effects, Respiration, Sheep

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Prenatal Nicotine Exposure Blunts the Cardiorespiratory Response to Hypoxia in Lambs

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