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Nontuberculous Mycobacteria: I: Multicenter Prevalence Study in Cystic Fibrosis
Open accessAbstract
Nontuberculous mycobacteria (NTM) are potential respiratory pathogens in cystic fibrosis (CF). To assess the species-specific prevalence and risk factors for acquisition, we conducted a prospective, cross-sectional study of the prevalence of NTM and clinical features of patients at 21 U.S. centers. Almost 10% of patients with CF who were 10 years or older were included (n = 986). The overall prevalence of NTM in sputum was 13.0% (range by center, 7-24%). Mycobacterium avium complex (72%) and Mycobacterium abscessus (16%) were the most common species. When compared with patients with CF without NTM, culture-positive subjects were older (26 vs. 22 years, p < 0.001), had a higher FEV1 (60 vs. 54%, p < 0.01), higher frequency of Staphylococcus aureus (43 vs. 31%, p < 0.01), and lower frequency of Pseudomonas aeruginosa (71 vs. 82%, p < 0.01). Molecular typing revealed that almost all patients within each center had unique NTM strains. In summary, NTM are common in patients with CF, but neither person-to-person nor nosocomial acquisition explained the high prevalence. Older age was the most significant predictor for isolation of NTM. The clinical significance of NTM in CF is incompletely defined, but patients with these organisms should be monitored with repeat cultures.
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Cited by
Griffith, D. E., Aksamit, T., Brown-Elliott, B. A., Catanzaro, A., Daley, C., Gordin, F., Holland, S. M., Horsburgh, R., Huitt, G., Iademarco, M. F., et al. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200604-571st · Cited by 6,110
Self-citationPathophysiology and Management of Pulmonary Infections in Cystic Fibrosis
Gibson, R. L., Burns, J. L., & Ramsey, B. W. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200304-505so · Cited by 1,633
O'Sullivan, B. P., & Freedman, S. D. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60327-5 · Cited by 1,320
Saiman, L., Marshall, B. C., Mayer-Hamblett, N., Burns, J. L., Quittner, A. L., Cibene, D. A., Coquillette, S., Fieberg, A. Y., Accurso, F. J., Campbell III, P. W., et al. (2003) · JAMA · doi:10.1001/jama.290.13.1749 · Cited by 958
Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus
Johansen, M. D., Herrmann, J.-L., & Kremer, L. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0331-1 · Cited by 822
Metadata
- Authors
- Olivier, K. N., Weber, D. J., Wallace, R. J., Faiz, A. R., Lee, J.-H., Zhang, Y., Brown-Elliot, B. A., Handler, A., Wilson, R. W., Schechter, M. S., Edwards, L. J., Chakraborti, S., & Knowles, M. R.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-03-15
- Volume
- 167
- Issue
- 6
- Pages
- 828-834
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2167468135
- Cited by
- 631
- References
- 0
- FWCI
- 15.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Olivier, K. N., Weber, D. J., Wallace, R. J., Faiz, A. R., Lee, J.-H., Zhang, Y., Brown-Elliot, B. A., Handler, A., Wilson, R. W., Schechter, M. S., Edwards, L. J., Chakraborti, S., & Knowles, M. R. (2003). Nontuberculous Mycobacteria: I: Multicenter Prevalence Study in Cystic Fibrosis. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200207-678oc
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