The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
The Epidemiology of Severe Sepsis in Children in the United States
Abstract
Despite extensive research into the etiology and treatment of severe sepsis, little is known about its epidemiology in children. We sought to determine the age- and sex-adjusted incidence, outcome, and associated hospital costs of severe sepsis in United States children using 1995 hospital discharge and population data from seven states (24% of the United States population). Of 1,586,253 hospitalizations in children who were 19 years old or less, 9,675 met International Classification of Diseases, 9th revision, clinical modification-based severe sepsis criteria or 42,364 cases of pediatric severe sepsis per year nationally (0.56 cases per 1,000 population per year). The incidence was the highest in infants (5.16 per 1,000), fell dramatically in older children (0.20 per 1,000 in 10 to 14 year olds), and was 15% higher in boys than in girls (0.60 versus 0.52 per 1,000, p < 0.001). Hospital mortality was 10.3%, or 4,383 deaths nationally (6.2 per 100,000 population). Half of the cases had underlying disease (49.0%), and over one-fifth (22.9%) were low-birth-weight newborns. Respiratory infections (37%) and primary bacteremia (25%) were the most common infections. The mean length of stay and cost were 31 days and $40,600, respectively. Estimated annual total costs were 1.97 billion US dollars nationally. Severe sepsis is a significant health problem in children and is associated with the use of extensive healthcare resources. Infants are at highest risk, especially those with a low birth weight.
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Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503
Self-citationEfficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis
Bernard, G. R., Vincent, J.-L., Laterre, P.-F., LaRosa, S. P., Dhainaut, J.-F., Lopez-Rodriguez, A., Steingrub, J. S., Garber, G. E., Helterbrand, J. D., Ely, E. W., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103083441001 · Cited by 6,132
Nosocomial infections in medical intensive care units in the United States
Richards, M. J., Edwards, J. R., Culver, D. H., & Gaynes, R. P. (1999) · Critical Care Medicine · doi:10.1097/00003246-199905000-00020 · Cited by 1,565
High-Dose Antithrombin III in Severe Sepsis: A Randomized Controlled Trial
Warren, B. L., Eid, A., Singer, P., Pillay, S. S., Carl, P., Novak, I., Chalupa, P., Atherstone, A., Pénzes, I., Kübler, A., et al. (2001) · JAMA · doi:10.1001/jama.286.15.1869 · Cited by 1,419
Treating Patients with Severe Sepsis
Wheeler, A. P., & Bernard, G. R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901213400307 · Cited by 992
Feudtner, C., Christakis, D. A., & Connell, F. A. (2000) · Pediatrics · doi:10.1542/peds.106.s1.205 · Cited by 810
Gonadal Steroids and Immunity*
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Epidemiology of Sepsis Syndrome in 8 Academic Medical Centers
Sands, K. E. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03550030074038 · Cited by 663
Cited by
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock
Dellinger, R. P., Levy, M. M., Rhodes, A., Annane, D., Gerlach, H., Opal, S. M., Sevransky, J. E., Sprung, C. L., Douglas, I. S., Jaeschke, R., et al. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31827e83af · Cited by 9,694
Self-citationRudd, K. E., Johnson, S. C., Agesa, K. M., Shackelford, K. A., Tsoi, D., Kievlan, D. R., Colombara, D. V., Ikuta, K. S., Kissoon, N., Finfer, S., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(19)32989-7 · Cited by 7,971
Self-citationThe global burden of paediatric and neonatal sepsis: a systematic review
Fleischmann-Struzek, C., Goldfarb, D. M., Schlattmann, P., Schlapbach, L. J., Reinhart, K., & Kissoon, N. (2018) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30063-8 · Cited by 1,040
Zaoutis, T. E., Argon, J., Chu, J., Berlin, J. A., Walsh, T. J., & Feudtner, C. (2005) · Clinical Infectious Diseases · doi:10.1086/496922 · Cited by 784
Jawad, I., Lukšić, I., & Rafnsson, S. B. (2012) · Journal of Global Health · doi:10.7189/jogh.01.010404 · Cited by 389
Metadata
- Authors
- Watson, R. S., Carcillo, J. A., Linde-Zwirble, W. T., Clermont, G., Lidicker, J., & Angus, D. C.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-03-01
- Volume
- 167
- Issue
- 5
- Pages
- 695-701
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2156828749
- Cited by
- 874
- References
- 30
- FWCI
- 15.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Watson, R. S., Carcillo, J. A., Linde-Zwirble, W. T., Clermont, G., Lidicker, J., & Angus, D. C. (2003). The Epidemiology of Severe Sepsis in Children in the United States. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200207-682oc
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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